YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRH_ECOLI
Organism:	Escherichia coli
Length:	241 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRH_ECOLI.

Description	E-value	Query Range	Subject Range
PYRH_PSEA6 - Uridylate kinase OS=Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) GN=pyrH PE=3 SV=1	247.0	[0..1]	[240..1]
PYRH_COLP3 - Uridylate kinase OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=pyrH PE=3 SV=1	246.0	[0..1]	[240..1]
gi\|90437851, gi\|... - gi\|90580973\|ref\|ZP_01236774.1\| uridylate kinase [Vibrio angustum S14], gi\|90437851\|gb\|EAS63041.1\| ur...	244.0	[0..1]	[240..1]
gi\|89048834, gi\|... - gi\|89075418\|ref\|ZP_01161835.1\| uridylate kinase [Photobacterium sp. SKA34], gi\|89048834\|gb\|EAR54404.... gi\|88813751, gi\|... - gi\|88813751\|ref\|ZP_01128969.1\| uridylate kinase [Nitrococcus mobilis Nb-231], gi\|88788995\|gb\|EAR2014...	244.0	[0..1]	[240..1]
gi\|85712040, gi\|... - gi\|85712040\|ref\|ZP_01043094.1\| uridylate kinase [Idiomarina baltica OS145], gi\|85694226\|gb\|EAQ32170....	243.0	[0..1]	[241..1]
gi\|15292789, gi\|... - gi\|9293891\|dbj\|BAB01794.1\| unnamed protein product [Arabidopsis thaliana], gi\|20258857\|gb\|AAM14100.1...	242.0	[0..2]	[239..89]
gi\|238714199, gi... - gi\|77957691\|ref\|ZP_00821740.1\| COG0528: Uridylate kinase [Yersinia bercovieri ATCC 43970], gi\|238784... gi\|238727861, gi... - gi\|77977746\|ref\|ZP_00833187.1\| COG0528: Uridylate kinase [Yersinia intermedia ATCC 29909], gi\|238792...	242.0	[0..1]	[241..1]
PYRH_SHEAM - Uridylate kinase OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=pyrH PE=3 SV=1	242.0	[0..1]	[241..1]
PYRH_IDILO - Uridylate kinase OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) GN=pyrH PE=3 SV=... PYRH_IDILO - Uridylate kinase OS=Idiomarina loihiensis GN=pyrH PE=3 SV=1	242.0	[0..1]	[241..2]
gi\|77963173, gi\|... - gi\|77963173\|ref\|ZP_00826985.1\| COG0528: Uridylate kinase [Yersinia mollaretii ATCC 43969], gi\|238796...	242.0	[0..1]	[241..1]

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Predicted Domain #1

Region A:
Residues: [1-241]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNAKPVYK RILLKLSGEA LQGTEGFGID ASILDRMAQE IKELVELGIQ VGVVIGGGNL  60
   61 FRGAGLAKAG MNRVVGDHMG MLATVMNGLA MRDALHRAYV NARLMSAIPL NGVCDSYSWA 120
  121 EAISLLRNNR VVILSAGTGN PFFTTDSAAC LRGIEIEADV VLKATKVDGV FTADPAKDPT 180
  181 ATMYEQLTYS EVLEKELKVM DLAAFTLARD HKLPIRVFNM NKPGALRRVV MGEKEGTLIT 240
  241 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.69897
Match:	2bneA
Description:	The structure of E. coli UMP kinase in complex with UMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
kinase activity	5.43826659128409	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	4.76215533422168	bayes_pls_golite062009
nucleotide kinase activity	4.36245911991838	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.17538459617947	bayes_pls_golite062009
uridylate kinase activity	3.54453921304057	bayes_pls_golite062009
catalytic activity	3.20382750184555	bayes_pls_golite062009
transferase activity	2.54481238004476	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.89315414622708	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	1.02979719559565	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: