YRC Public Data Repository - Protein Structure Prediction

Protein:	EG20248
Organism:	Escherichia coli K-12
Length:	486 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG20248.

Description	E-value	Query Range	Subject Range
gi\|75198138, gi\|... - gi\|75198138\|ref\|ZP_00708208.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c...	652.0	[0..1]	[486..1]
gi\|75258404, gi\|... - gi\|75258404\|ref\|ZP_00729835.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c...	651.0	[0..1]	[486..1]
gi\|75179382, gi\|... - gi\|75179382\|ref\|ZP_00699386.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Shigella boyd... gi\|81248081, gi\|... - gi\|82546670\|ref\|YP_410617.1\| D-mannonate oxidoreductase [Shigella boydii Sb227], gi\|81248081\|gb\|ABB6...	651.0	[0..1]	[486..1]
gi\|26111644, gi\|... - gi\|26251211\|ref\|NP_757251.1\| D-mannonate oxidoreductase [Escherichia coli CFT073], gi\|26111644\|gb\|AA... gi\|227838017, gi... - gi\|227885188\|ref\|ZP_04002993.1\| fructuronate reductase [Escherichia coli 83972], gi\|227838017\|gb\|EEJ...	651.0	[0..1]	[486..1]
gi\|189357881, gi... - gi\|189357881\|gb\|EDU76300.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4401], gi\|168754... gi\|168749520, gi... - gi\|188016196\|gb\|EDU54318.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4113], gi\|168749... gi\|189364289, gi... - gi\|189364289\|gb\|EDU82708.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4486], gi\|168766... gi\|189368891, gi... - gi\|189368891\|gb\|EDU87307.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4501], gi\|168760... gi\|168781607, gi... - gi\|189000792\|gb\|EDU69778.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4076], gi\|168781... gi\|168773971, gi... - gi\|187770267\|gb\|EDU34111.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4196], gi\|168773... gi\|254595725, gi... - gi\|254796325\|ref\|YP_003081162.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli O157:H7 s... gi\|209749274, gi... - pir\|\|E86130 mannonate oxidoreductase [imported] - Escherichia coli (strain O157:H7, substrain EDL93... gi\|15804898, gi\|... - gi\|15804898\|ref\|NP_290939.1\| mannonate oxidoreductase [Escherichia coli O157:H7 EDL933], gi\|12519333... gi\|13364760, gi\|... - gi\|15834536\|ref\|NP_313309.1\| D-mannonate oxidoreductase [Escherichia coli O157:H7], gi\|13364760\|dbj\|... gi\|194423261, gi... - gi\|83586652\|ref\|ZP_00925284.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|168797890, gi... - gi\|189379523\|gb\|EDU97939.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC508], gi\|1687978... gi\|194415383, gi... - gi\|75212115\|ref\|ZP_00712155.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|189374780, gi... - gi\|189374780\|gb\|EDU93196.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC869], gi\|1687849... gi\|208806843, gi... - gi\|208806843\|ref\|ZP_03249180.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|195937332 - gi\|195937332\|ref\|ZP_03082714.1\| D-mannonate oxidoreductase [Escherichia coli O157:H7 str. EC4024] gi\|208820100, gi... - gi\|208820100\|ref\|ZP_03260420.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4042], gi\|20... gi\|208733743, gi... - gi\|208812466\|ref\|ZP_03253795.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|75229721, gi\|... - gi\|75229721\|ref\|ZP_00716254.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|13364760, gi\|... - gi\|15834536\|ref\|NP_313309.1\| D-mannonate oxidoreductase [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|217325964, gi... - gi\|217325964\|ref\|ZP_03442048.1\| fructuronate reductase [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|73858247, gi\|... - gi\|74314770\|ref\|YP_313189.1\| D-mannonate oxidoreductase [Shigella sonnei Ss046], gi\|73858247\|gb\|AAZ9... gi\|209399476, gi... - gi\|209399476\|ref\|YP_002273848.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4115], gi\|2...	651.0	[0..1]	[486..1]
gi\|110346358, gi... - gi\|110644766\|ref\|YP_672496.1\| D-mannonate oxidoreductase [Escherichia coli 536], gi\|110346358\|gb\|ABG... gi\|75242243, gi\|... - gi\|75242243\|ref\|ZP_00726005.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|237704066, gi... - gi\|237704066\|ref\|ZP_04534547.1\| D-mannonate oxidoreductase [Escherichia sp. 3_2_53FAA], gi\|226901978... gi\|218556854, gi... - gi\|218556854\|ref\|YP_002389768.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli IAI1], gi... gi\|52420908 - gi\|52420908\|emb\|CAH55787.1\| mannonate oxidoreductase [Escherichia coli] gi\|218692724, gi... - gi\|218692724\|ref\|YP_002400936.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli ED1a], gi... gi\|209921787, gi... - gi\|209921787\|ref\|YP_002295871.1\| mannonate oxidoreductase [Escherichia coli SE11], gi\|209915046\|dbj\|... gi\|215267718, gi... - gi\|215489646\|ref\|YP_002332077.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli O127:H6 s...	651.0	[0..1]	[486..1]
gi\|75235103, gi\|... - gi\|75235103\|ref\|ZP_00719359.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|218368268, gi... - gi\|218561499\|ref\|YP_002394412.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli S88], gi\|...	649.0	[0..1]	[486..1]
gi\|188489319, gi... - gi\|75515506\|ref\|ZP_00737663.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c...	649.0	[0..1]	[486..1]
gi\|117626630, gi... - gi\|117626630\|ref\|YP_859953.1\| D-mannonate oxidoreductase [Escherichia coli APEC O1], gi\|115515754\|gb... gi\|91213967, gi\|... - gi\|91213967\|ref\|YP_543953.1\| D-mannonate oxidoreductase [Escherichia coli UTI89], gi\|91075541\|gb\|ABE...	649.0	[0..1]	[486..1]
gi\|254037345, gi... - gi\|254037345\|ref\|ZP_04871422.1\| mannitol dehydrogenase [Escherichia sp. 1_1_43], gi\|226840451\|gb\|EEH... gi\|157157003, gi... - gi\|75189043\|ref\|ZP_00702310.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c...	647.0	[0..1]	[486..1]

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Predicted Domain #1

Region A:
Residues: [1-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTIVDSNLP VARPSWDHSR LESRIVHLGC GAFHRAHQAL YTHHLLESTD SDWGICEVNL  60
   61 MPGNDRVLIE NLKKQQLLYT VAEKGAESTE LKIIGSMKEA LHPEIDGCEG ILNAMARPQT 120
  121 AIVSLTVTEK GYCADAASGQ LDLNNPLIKH DLENPTAPKS AIGYIVEALR LRREKGLKAF 180
  181 TVMSCDNVRE NGHVAKVAVL GLAQARDPQL AAWIEENVTF PCTMVDRIVP AATPETLQEI 240
  241 ADQLGVYDPC AIACEPFRQW VIEDNFVNGR PDWDKVGAQF VADVVPFEMM KLRMLNGSHS 300
  301 FLAYLGYLGG YETIADTVTN PAYRKAAFAL MMQEQAPTLS MPEGTDLNAY ATLLIERFSN 360
  361 PSLRHRTWQI AMDGSQKLPQ RLLDPVRLHL QNGGSWRHLA LGVAGWMRYT QGVDEQGNAI 420
  421 DVVDPMLAEF QKINAQYQGA DRVKALLGLS GIFADDLPQN ADFVGAVTAA YQQLCERGAR 480
  481 ECVAAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.0
Match:	1lj8A
Description:	Mannitol 2-dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	1.69771604880532	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	0.882672090231461	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	0.138709569969554	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: