YRC Public Data Repository - Protein Structure Prediction

Protein:	ENVZ_SHIFL
Organism:	Shigella flexneri
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENVZ_SHIFL.

Description	E-value	Query Range	Subject Range
gi\|45440000, gi\|... - gi\|45440000\|ref\|NP_991539.1\| osmolarity sensor protein [Yersinia pestis biovar Microtus str. 91001],...	280.0	[0..1]	[450..1]
gi\|25298449 - pir\|\|AF0017 osmolarity sensor protein (EC 2.7.3.-) [imported] - Yersinia pestis (strain CO92) gi\|51598053, gi\|... - gi\|51598053\|ref\|YP_072244.1\| osmolarity sensor protein [Yersinia pseudotuberculosis IP 32953], gi\|51... gi\|22127787, gi\|... - gi\|22127787\|ref\|NP_671210.1\| osmolarity sensor protein [Yersinia pestis KIM], gi\|21960916\|gb\|AAM8746... Q664K6\|Q664K6_YERPS - Osmolarity sensor protein precursor - Yersinia pseudotuberculosis gi\|218927348, gi... - gi\|218927348\|ref\|YP_002345223.1\| osmolarity sensor protein [Yersinia pestis CO92], gi\|16120480\|ref\|N... gi\|166010415, gi... - gi\|166010415\|ref\|ZP_02231313.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|229706450, gi... - gi\|229836382\|ref\|ZP_04456549.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|165928059, gi... - gi\|165928059\|ref\|ZP_02223891.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Orientalis st... gi\|229696359, gi... - gi\|229839993\|ref\|ZP_04460152.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|167051326, gi... - gi\|167398822\|ref\|ZP_02304346.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|229690384, gi... - gi\|229842074\|ref\|ZP_04462229.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|77633467, gi\|... - gi\|77633467\|ref\|ZP_00795597.1\| COG0642: Signal transduction histidine kinase [Yersinia pestis Angola... gi\|166213218, gi... - gi\|166213218\|ref\|ZP_02239253.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|167425631, gi... - gi\|167425631\|ref\|ZP_02317384.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Mediaevalis s... gi\|166963036, gi... - gi\|167419042\|ref\|ZP_02310795.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Orientalis st... gi\|186700279, gi... - gi\|186897253\|ref\|YP_001874365.1\| osmolarity sensor protein [Yersinia pseudotuberculosis PB1/+], gi\|1... gi\|170022434, gi... - gi\|170022434\|ref\|YP_001718939.1\| osmolarity sensor protein [Yersinia pseudotuberculosis YPIII], gi\|1... gi\|165936352, gi... - gi\|89105813\|ref\|ZP_01178326.1\| COG0642: Signal transduction histidine kinase [Yersinia pestis biovar... gi\|108809323, gi... - gi\|108809323\|ref\|YP_653239.1\| osmolarity sensor protein [Yersinia pestis Antiqua], gi\|108781236\|gb\|A... gi\|108777736, gi... - gi\|229904625\|ref\|ZP_04519736.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|149290227, gi... - gi\|150260819\|ref\|ZP_01917547.1\| osmolarity sensor protein [Yersinia pestis CA88-4125], gi\|149290227\|... gi\|145209083, gi... - gi\|145597387\|ref\|YP_001161462.1\| osmolarity sensor protein [Yersinia pestis Pestoides F], gi\|1452090...	280.0	[0..1]	[450..1]
gi\|152959614, gi... - gi\|77631119\|ref\|ZP_00793705.1\| COG0642: Signal transduction histidine kinase [Yersinia pseudotubercu...	279.0	[0..1]	[450..1]
gi\|218429245, gi... - gi\|218691681\|ref\|YP_002399893.1\| osmolarity sensor protein [Escherichia coli ED1a], gi\|218429245\|emb... gi\|190908126, gi... - gi\|75241505\|ref\|ZP_00725350.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|110643637, gi... - gi\|110643637\|ref\|YP_671367.1\| osmolarity sensor protein [Escherichia coli 536], gi\|110345229\|gb\|ABG7...	278.0	[0..1]	[450..1]
gi\|15833500, gi\|... - gi\|15833500\|ref\|NP_312273.1\| osmolarity sensor protein [Escherichia coli O157:H7 str. Sakai], gi\|133... gi\|15833500, gi\|... - gi\|15833500\|ref\|NP_312273.1\| osmolarity sensor protein [Escherichia coli O157:H7], gi\|13363720\|dbj\|B... gi\|208739839, gi... - gi\|208819716\|ref\|ZP_03260036.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4042... gi\|25298452, gi\|... - pir\|\|E86005 protein histidine kinase/phosphatase EnvZ [imported] - Escherichia coli (strain O157:H7,... gi\|208734794, gi... - gi\|208813517\|ref\|ZP_03254846.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4045... gi\|217321412, gi... - gi\|217325191\|ref\|ZP_03441275.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. TW1458... gi\|12518031, gi\|... - gi\|15803908\|ref\|NP_289944.1\| osmolarity sensor protein [Escherichia coli O157:H7 EDL933], gi\|1251803... gi\|209158826, gi... - gi\|209397426\|ref\|YP_002272839.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC411... gi\|168797174, gi... - gi\|189379930\|gb\|EDU98346.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC508], gi... gi\|189374410, gi... - gi\|189374410\|gb\|EDU92826.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC869], gi... gi\|208807616, gi... - gi\|208807616\|ref\|ZP_03249953.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4206... gi\|195934893 - gi\|195934893\|ref\|ZP_03080275.1\| osmolarity sensor protein [Escherichia coli O157:H7 str. EC4024] gi\|189364652, gi... - gi\|189364652\|gb\|EDU83071.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4486], g... gi\|189369894, gi... - gi\|189369894\|gb\|EDU88310.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4501], g... gi\|189002223, gi... - gi\|189002223\|gb\|EDU71209.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4076], g... gi\|168772705, gi... - gi\|187771797\|gb\|EDU35641.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4196], g... gi\|189359046, gi... - gi\|189359046\|gb\|EDU77465.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4401], g... gi\|168747119, gi... - gi\|188018349\|gb\|EDU56471.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4113], g... gi\|254594719, gi... - gi\|254795319\|ref\|YP_003080156.1\| sensory histidine kinase in two-component regulatory system with Om...	277.0	[0..1]	[450..1]
gi\|79091, gi\|47665 - pir\|\|S01367 inner membrane protein envZ - Salmonella typhimurium, gi\|47665\|emb\|CAA30935.1\| unnamed p... gi\|47665\|emb\|CAA... - unnamed protein product [Salmonella typhimurium]	277.0	[0..1]	[450..1]
gi\|56415416, gi\|... - gi\|56415416\|ref\|YP_152491.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... gi\|161365905, gi... - gi\|161616541\|ref\|YP_001590506.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica sero... ENVZ_SALTY - Osmolarity sensor protein envZ OS=Salmonella typhimurium GN=envZ PE=3 SV=2 ENVZ_SALTY - Osmolarity sensor protein EnvZ OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=en... lcl\|NC_016856.1_... - [gene=envZ] [protein=osmolarity sensor protein] [protein_id=YP_005239702.1] [location=complement(367... ENVZ_SALTY - Osmolarity sensor protein EnvZ OS=Salmonella typhimurium GN=envZ PE=3 SV=2	277.0	[0..1]	[450..1]
ENVZ_SALTI - Osmolarity sensor protein envZ OS=Salmonella typhi GN=envZ PE=3 SV=2 gi\|29144273, gi\|... - gi\|29144273\|ref\|NP_807615.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... gi\|16762786 - gi\|16762786\|ref\|NP_458403.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... ENVZ_SALTI - Osmolarity sensor protein EnvZ OS=Salmonella typhi GN=envZ PE=3 SV=2	277.0	[0..1]	[450..1]
gi\|26110433, gi\|... - gi\|26250004\|ref\|NP_756044.1\| osmolarity sensor protein [Escherichia coli CFT073], gi\|26110433\|gb\|AAN... gi\|91212878, gi\|... - gi\|91212878\|ref\|YP_542864.1\| osmolarity sensor protein [Escherichia coli UTI89], gi\|91074452\|gb\|ABE0... gi\|115514795, gi... - gi\|117625671\|ref\|YP_858994.1\| osmolarity sensor protein [Escherichia coli APEC O1], gi\|115514795\|gb\|... gi\|218367231, gi... - gi\|218560462\|ref\|YP_002393375.1\| osmolarity sensor protein [Escherichia coli S88], gi\|218367231\|emb\|... gi\|226902398, gi... - gi\|237703134\|ref\|ZP_04533615.1\| osmolarity sensor protein envZ [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|170518903, gi... - gi\|170681185\|ref\|YP_001745652.1\| osmolarity sensor protein EnvZ [Escherichia coli SMS-3-5], gi\|17051... gi\|215266757, gi... - gi\|215488685\|ref\|YP_002331116.1\| osmolarity sensor protein [Escherichia coli O127:H6 str. E2348/69],... gi\|227883538, gi... - gi\|227883538\|ref\|ZP_04001343.1\| sensory histidine kinase in two-component regulatory system with Omp...	277.0	[0..1]	[450..1]
gi\|541207 - gi\|541207\|pir\|\|S41888 envZ protein - Salmonella typhi	276.0	[0..1]	[450..1]

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Predicted Domain #1

Region A:
Residues: [1-148]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRLRFSPRS SFARTLLLIV TLLFASLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD  60
   61 KLQLEDGTQL VVPPAFRREI YRELGISLYS NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT 120
  121 EVRVEVNKSS PVVWLKTWLS PNIWVRVP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [149-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEIHQGDFS PLFRYTLAIM LLAIGGAWLF IRIQNRPLVD LEHAALQVGK GIIPPPLREY  60
   61 GASEVRSVTR AFNHMAAGVK QLADDRTLLM AGVSHDLRTP LTRIRLATEM MSEQDGYLAE 120
  121 SI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.34
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [271-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKDIEECNAI IEQFIDYLRT GQEMPMEMAD LNAVLGEVIA AESGYEREIE TALYPGSIEV  60
   61 KMHPLSIKRA VANMVVNAAR YGNGWIKVSS GTEPNRAWFQ VEDDGPGIAP EQRKHLFQPF 120
  121 VRGDSARTIS GTGLGLAIVQ RIVDNHNGML ELGTSERGGL SIRAWLPVPV TRAQGTTKEG 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.30103
Match:	1bxdA
Description:	Histidine kinase domain of the osmosensor EnvZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	4.82398483954378	bayes_pls_golite062009
two-component sensor activity	4.79766298875975	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	4.76164614213074	bayes_pls_golite062009
two-component response regulator activity	3.47298917518553	bayes_pls_golite062009
signal transducer activity	2.91676094682887	bayes_pls_golite062009
molecular transducer activity	2.91676094682887	bayes_pls_golite062009
protein kinase activity	2.34507002285329	bayes_pls_golite062009
kinase activity	2.18775056477858	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.17409873880782	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.98933866931605	bayes_pls_golite062009
transferase activity	1.07472897478108	bayes_pls_golite062009
catalytic activity	0.812403102604677	bayes_pls_golite062009
binding	0.162154598845105	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: