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View Structure Prediction Details

Protein: INS_LOPAM
Organism: Lophius americanus
Length: 116 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INS_LOPAM.

Description E-value Query
Range		 Subject
Range
INS_ORENI - Insulin OS=Oreochromis niloticus GN=ins PE=1 SV=2
 134.0 [0..1] [116..1]
INS_VERMO - Insulin OS=Verasper moseri GN=ins PE=3 SV=1
 130.0 [0..1] [116..1]
gi|109240262 - gi|109240262|dbj|BAE96120.1| insulin [Seriola dumerili]
 128.0 [0..1] [116..1]
INS_CHICK - Insulin OS=Gallus gallus GN=INS PE=1 SV=1
 126.0 [0..3] [116..2]
gi|47221426 - gi|47221426|emb|CAF97344.1| unnamed protein product [Tetraodon nigroviridis]
 126.0 [0..1] [116..1]
INS1_RAT - Insulin-1 OS=Rattus norvegicus GN=Ins1 PE=1 SV=1
 123.0 [0..3] [116..2]
INS_CYPCA - Insulin OS=Cyprinus carpio GN=ins PE=1 SV=1
 120.0 [0..3] [116..2]
INS_MACFA - Insulin OS=Macaca fascicularis GN=INS PE=3 SV=1
 120.0 [0..3] [116..2]
gi|13517219 - gi|13517219|gb|AAK28709.1| preproinsulin [Catostomus commersoni]
 119.0 [0..3] [116..2]
gi|13991923 - gi|13991923|gb|AAK51558.1|AF373021_1 preproinsulin [Catla catla]
 119.0 [0..3] [116..2]

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Predicted Domain #1
Region A:
Residues: [1-116] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALWLQSFS LLVLLVVSWP GSQAVAPAQH LCGSHLVDAL YLVCGDRGFF YNPKRDVDQL  60
   61 LGFLPPKSGG AAAAGADNEV AEFAFKDQME MMVKRGIVEQ CCHRPCNIFD LQNYCN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1efeA
Description: Insulin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.68523681696587 bayes_pls_golite062009
growth factor activity 4.53461171884462 bayes_pls_golite062009
insulin receptor binding 4.37297713474357 bayes_pls_golite062009
insulin-like growth factor receptor binding 4.05618549474014 bayes_pls_golite062009
protein binding 2.94317823862812 bayes_pls_golite062009
hormone activity 2.72072335887093 bayes_pls_golite062009
insulin-like growth factor binding 2.70552890170172 bayes_pls_golite062009
binding 2.54284380980739 bayes_pls_golite062009
protease binding 1.89624458747028 bayes_pls_golite062009
growth factor binding 1.84573028463276 bayes_pls_golite062009
protein complex binding 1.59564778820544 bayes_pls_golite062009
enzyme binding 0.151798820633953 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle