YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7443563
Organism:	Plasmodium falciparum
Length:	427 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7443563.

Description	E-value	Query Range	Subject Range
gi\|74142070 - gi\|74142070\|dbj\|BAE41096.1\| unnamed protein product [Mus musculus]	590.0	[0..2]	[427..6]
ETF1 - eukaryotic translation termination factor 1 ERF1_MOUSE - Eukaryotic peptide chain release factor subunit 1 OS=Mus musculus GN=Etf1 PE=1 SV=4 ERF1_MESAU - Eukaryotic peptide chain release factor subunit 1 OS=Mesocricetus auratus GN=ETF1 PE=1 SV=3 gi\|118097222 - gi\|118097222\|ref\|XP_414511.2\| PREDICTED: similar to C11 protein [Gallus gallus] ERF1_RABIT - Eukaryotic peptide chain release factor subunit 1 OS=Oryctolagus cuniculus GN=ETF1 PE=1 SV=3 gi\|114601971, gi... - gi\|114601971\|ref\|XP_001171542.1\| PREDICTED: eukaryotic translation termination factor 1 isoform 3 [P... gi\|126290367 - gi\|126290367\|ref\|XP_001368222.1\| PREDICTED: similar to C11 protein [Monodelphis domestica] tr\|M3WU44\|M3WU44... - Uncharacterized protein OS=Felis catus GN=ETF1 PE=4 SV=1 ERF1_RAT - Eukaryotic peptide chain release factor subunit 1 OS=Rattus norvegicus GN=Etf1 PE=2 SV=3 gi\|73970878, gi\|... - gi\|73978635\|ref\|XP_531922.2\| PREDICTED: similar to eukaryotic translation termination factor 1 (pred... ENSCJAT00000013296 - null gi\|109078786 - gi\|109078786\|ref\|XP_001113021.1\| PREDICTED: similar to eukaryotic translation termination factor 1 (... ERF1_BOVIN - Eukaryotic peptide chain release factor subunit 1 OS=Bos taurus GN=ETF1 PE=2 SV=3	589.0	[0..2]	[427..6]
ERF1_XENTR - Eukaryotic peptide chain release factor subunit 1 OS=Xenopus tropicalis GN=etf1 PE=2 SV=1	589.0	[0..2]	[427..6]
ERF1_XENLA - Eukaryotic peptide chain release factor subunit 1 OS=Xenopus laevis GN=etf1 PE=2 SV=1	588.0	[0..2]	[427..6]
ERF1_PONPY - Eukaryotic peptide chain release factor subunit 1 - Pongo pygmaeus (Orangutan) ERF1_PONAB - Eukaryotic peptide chain release factor subunit 1 OS=Pongo abelii GN=ETF1 PE=2 SV=3	587.0	[0..2]	[427..6]
gi\|91076450 - gi\|91076450\|ref\|XP_971668.1\| PREDICTED: similar to eukaryotic release factor 1 CG5605-PA [Tribolium ...	585.0	[0..2]	[421..6]

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Predicted Domain #1

Region A:
Residues: [1-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDHDANVEQ WKIKRLIKKL ENAKGNGTSM ISLIIKNKDE VSRINKMLAD ELGTASNIKS  60
   61 RVNRLSVLSA ITSTQQKLKL YNKTPPKGLV VYCGTVITED GKEKKMSIDF EPFRPINTSL 120
  121 YLCDNKFHVE ALKELLESDD KFGFIIVDGN GALFGTIQGN TREVIRRFTV DLPKKHGRGG 180
  181 QSALRFARLR LEKRHNYVRK VAEVATSVFI TNDKVNVTGI VLAGSADFKN DLLNSDMFDQ 240
  241 RLFAKVIKIV DISYGGDNGF NQAIELSSEA LQNVKFIQEK KLIGKFFEEI AQDTGKVVYG 300
  301 IDDTLKALEI GAVELLILYE GLDIIRLTTK NPVTNQTKTM HISPCDEKQE SLYKENNVEL 360
  361 EVVEKISLTD WVIGNYKKYG ASLDFVTNKS QEGAQFQKGF GGFGGMLRYK IDLNLYDEDV 420
  421 ESDVELF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	169.0
Match:	1dt9A
Description:	Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation release factor activity	11.5102558694213	bayes_pls_golite062009
translation termination factor activity	11.4768548464911	bayes_pls_golite062009
translation release factor activity, codon specific	7.66455753522311	bayes_pls_golite062009
structural constituent of ribosome	2.97154934968642	bayes_pls_golite062009
nucleic acid binding	2.70960972397471	bayes_pls_golite062009
structural molecule activity	2.64319832043379	bayes_pls_golite062009
binding	2.24516466558786	bayes_pls_golite062009
translation regulator activity	1.83257472130927	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.81472167858216	bayes_pls_golite062009
RNA binding	1.59103459949328	bayes_pls_golite062009
mRNA binding	0.607146672130391	bayes_pls_golite062009
protein binding	0.381324299701367	bayes_pls_golite062009
catalytic activity	0.264002643439785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: