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View Structure Prediction Details

Protein: gi|16804969, gi|...
Organism: Plasmodium falciparum 3D7
Length: 930 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16804969, gi|....

Description E-value Query
Range
Subject
Range
gi|7494432 - pir||G71617 SERA antigen/papain-like proteinase with active Cys PFB0330c - malaria parasite (Plasmod...
gi|3845155, gi|1... - gi|3845155|gb|AAC71855.1| serine repeat antigen 7 (SERA-7) [Plasmodium falciparum 3D7], gi|16804965|...
721.0 [0..1] [930..1]
gi|7494463, gi|1... - pir||T30846 serine-repeat antigen 5 precursor - Plasmodium vivax, gi|1381094|gb|AAB02634.1| V-SERA ...
663.0 [0..1] [846..1]
gi|83315603 - gi|83315603|ref|XP_730865.1| Papain family cysteine protease [Plasmodium yoelii yoelii str. 17XNL]
gi|23490720 - gi|23490720|gb|EAA22430.1| Papain family cysteine protease, putative [Plasmodium yoelii yoelii]
631.0 [0..25] [927..205]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFSISLFLI LCVLFCKNDI KCTTVDESTK EGSQNPKNSS STTPASGSQK GSSSESPGSS  60
   61 VEKQSQESNK ESTNGGNVVS QGTPANTFGQ NSNNPSDSPQ GTSTLPSPPK SIDVKSAFLK 120
  121 HYKGVKVTGS CNANFQLFLV PHIFI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [146-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVETKENNIQ LDVKFLKLTK RIDFAKDKSM LKNKCESGKN QTFKFVLYFK DDILTIKWKV  60
   61 YEEKSATPQK SEENTVDIKL YKLPKLDQTI TSIQVHTLSI EGTSYLMESK DYSLGNNLPE 120
  121 KCDAIASDCF LSGNINVEKC LKCTLKVKKV EA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [298-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDECYKYVSK DKPKETKLAV SGSEVKEVKA ASVDHSNDKE YELSQSINNI LNKMYKKESN  60
   61 DEKNNKKELI KLEDADDSLQ KELNKYCNSL KEVDLNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1k3bA
Description: Dipeptidyl peptidase I (cathepsin C), exclusion domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [395-763]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLSKNEVGNE KDVFNNLTTL LKEHMLESHH VVFEKLKNSA LCLKNIDDWL KNKNGLIVPP  60
   61 SKYKLKDTNE KKELNNNVEV IEDMFKANEH GIVDLTKFPI DTNYSSYKHI DHTYCNNDYC 120
  121 NWSKDKNSCI SKINVEDQKN CALSWAFASK YHLETIKCMK GYEHIPISSL YIANCSKNEK 180
  181 KDVCTEGSNP LKVLQMIVEK GFLPTEGDYS YEQSKVGETC PEVQNGWVNL WANAKLLEQN 240
  241 NDEHNSLSTK GYTAYESEAF QKDMHSFVKL IKDEIMNKGS VIAYVKADKI MAYEFNGKKV 300
  301 QNLCGDKTPD HAVNIIGYGN YINDEHQKKS YWIVRNSWGK HWGDKGHFKV DMYGPSDCED 360
  361 NFIHSVVIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.69897
Match: 1cs8A
Description: (Pro)cathepsin L
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.529663942126259 bayes_pls_golite062009
hydrolase activity 0.16837900182603 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [764-858]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVDLPINQES VKKEPKIYNY YLKASPDFYH NLYYKNFDSQ KGKADQAENK KSYLYGQEES  60
   61 TSEQLPSSLS SPQNNKQSER SKEKVDIFHV LKHIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [859-930]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSKIKMGIVK YDHSDALGED NVCSRSYSSN PEKQEGCVKF CNENWGKCKD AASPGFCLSE  60
   61 LEKTNDCFFC YI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle