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View Structure Prediction Details

Protein: gi|7494435
Organism: Plasmodium falciparum
Length: 962 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7494435.

Description E-value Query
Range
Subject
Range
gi|7494463, gi|1... - pir||T30846 serine-repeat antigen 5 precursor - Plasmodium vivax, gi|1381094|gb|AAB02634.1| V-SERA ...
815.0 [0..1] [962..1]
gi|23593286, gi|... - gi|23593286|ref|NP_472999.2| cysteine protease, putative [Plasmodium falciparum 3D7], gi|23503374|gb...
766.0 [0..23] [962..74]
gi|83315603 - gi|83315603|ref|XP_730865.1| Papain family cysteine protease [Plasmodium yoelii yoelii str. 17XNL]
gi|23490720 - gi|23490720|gb|EAA22430.1| Papain family cysteine protease, putative [Plasmodium yoelii yoelii]
681.0 [0..25] [959..207]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIHIFLIAT IYVLFSEKLI KWTTASTTQG GDTDTHPGTP PGEGSDVSQG AGQDASQGAG  60
   61 QDANPDPTLP KPPSPPADDT KDTGSQGDAD SSSSKIEIPP LVKPENHKTI VSAMLKNYKG 120
  121 VKVTGTCGAD FGLFLVPHIY VHVKSEDTEI ELSSELAPPE MQTKFDKTQL KKF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [174-344]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVKDDTKKFD FIAYIYKDIL VFKWKVYEEG LSKEQDVDEM KYLLPNLKQP ITSIQVHSWT  60
   61 GTKESYILES KDYVLGEGMP EKCDAIATDC FLSGFTDIGK CFQCKLLMQE KNINDSCFKY 120
  121 VSSNQKELIK KQLKITAQDD EESSEYHLSE SIKNLLKNIY KKNNDDNKKK E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [345-719]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLHFENVNSA LKSELLNYCN LLKEVNMNGV LKDHQLGNVQ DVFNNLTKLL EEHKEENDNV  60
   61 LYHKMKNEAL CLKNVNDWMK NKTGLLLPQL SYDLTYKNNN FTEFTQNKSY TSQNIVDKLY 120
  121 CNHEYCNRLK DHNNCISKIN VEDQKNCALS WAFASKYHLE TIKCMKGYEP LNASVLYVTN 180
  181 CLKNKNKDVC TEGSNPLVFL ETIEEKGFLP TESNYPYDQS KVGDICPQLQ NDWDNVFENT 240
  241 KVLDYNNGPF SVGTKGYIAY ESEAFQKDMH SFVKLVKDEI MNKGSVIAYV KAENVLGYEL 300
  301 NGKKVQNLCG DKTPDHVVNI VGYGNYINNK GEKKSYWIVR NSWGKYWGDD GYFKVDMYGP 360
  361 STCEDNFIHT VVVFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.0
Match: 1cs8A
Description: (Pro)cathepsin L
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.529663942126259 bayes_pls_golite062009
hydrolase activity 0.16837900182603 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [720-962]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQVPINEKFD KKEHDIYNYY LKTSPEFYHN LYYKTFNSNK EEKSMNKNSY VYGQDTTPVE  60
   61 NEAPRSGVQK PTELSSTESQ TVSPPNESQT ESLLSGGSQV TNPTLTQSTS SSSGQQETGP 120
  121 LSTQGLSPAT GDPKGKEQEA SPAEGLSGVL NPTKEVTSEE KIQIIHLLKH IKNSKIRRGL 180
  181 VKYNHEFEVG DNSCSRSTSK NAEMHDECVN ICEKYWPECR GTAVPGYCLS THDDKNECDF 240
  241 CYV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.964
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle