YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|33320676
Organism:	Plasmodium falciparum
Length:	322 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|33320676.

Description	E-value	Query Range	Subject Range
gi\|83273848 - gi\|83273848\|ref\|XP_729578.1\| hydroxyacylglutathione hydrolase cytoplasmic [Plasmodium yoelii yoelii ... gi\|23487778 - gi\|23487778\|gb\|EAA21143.1\| hydroxyacylglutathione hydrolase cytoplasmic [Plasmodium yoelii yoelii]	233.0	[0..1]	[322..1]
gi\|115891513, gi... - gi\|115949376\|ref\|XP_001191822.1\| PREDICTED: similar to hydroxyacyl glutathione hydrolase [Strongyloc...	215.0	[0..58]	[321..1]
tr\|D7HE21\|D7HE21... - Hydroxyacylglutathione hydrolase OS=Vibrio cholerae RC385 GN=gloB PE=3 SV=1 gi\|116218207, gi... - gi\|75824349\|ref\|ZP_00753806.1\| COG0491: Zn-dependent hydrolases, including glyoxylases [Vibrio chole...	214.0	[0..57]	[319..1]
gi\|25406895, gi\|... - gi\|8810475\|gb\|AAF80136.1\|AC024174_18 Contains similarity to glyoxalase II isozyme from Arabidopsis t...	213.0	[0..48]	[321..247]
gi\|116190165, gi... - gi\|75831264\|ref\|ZP_00760529.1\| COG0491: Zn-dependent hydrolases, including glyoxylases [Vibrio chole... GLO2_VIBC3 - Hydroxyacylglutathione hydrolase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa... gi\|121726557, gi... - gi\|75817019\|ref\|ZP_00747475.1\| COG0491: Zn-dependent hydrolases, including glyoxylases [Vibrio chole... GLO2_VIBCM - Hydroxyacylglutathione hydrolase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=gloB PE=3 SV=1 gi\|229355194, gi... - gi\|229507689\|ref\|ZP_04397194.1\| hydroxyacylglutathione hydrolase [Vibrio cholerae BX 330286], gi\|229... gi\|183179464, gi... - gi\|183179464\|ref\|ZP_02957675.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae MZO... gi\|229519251, gi... - gi\|229519251\|ref\|ZP_04408694.1\| hydroxyacylglutathione hydrolase [Vibrio cholerae RC9], gi\|229343940... gi\|229522183, gi... - gi\|229522183\|ref\|ZP_04411600.1\| hydroxyacylglutathione hydrolase [Vibrio cholerae TM 11079-80], gi\|2... gi\|229332534, gi... - gi\|229528760\|ref\|ZP_04418150.1\| hydroxyacylglutathione hydrolase [Vibrio cholerae 12129(1)], gi\|2293... gi\|229607193, gi... - gi\|229607193\|ref\|YP_002877841.1\| hydroxyacylglutathione hydrolase [Vibrio cholerae MJ-1236], gi\|2293... gi\|121549549, gi... - gi\|121586283\|ref\|ZP_01676073.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae 274... gi\|254286455, gi... - gi\|254286455\|ref\|ZP_04961412.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae AM-... gi\|153213781, gi... - gi\|153213781\|ref\|ZP_01948989.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae 158... gi\|124119800, gi... - gi\|153221271\|ref\|ZP_01952286.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae MAK... gi\|148874588, gi... - gi\|153829953\|ref\|ZP_01982620.1\| putative hydroxyacylglutathione hydrolase GloB [Vibrio cholerae 623-... gi\|153825354, gi... - gi\|153825354\|ref\|ZP_01978021.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae MZO... gi\|153817113, gi... - gi\|153817113\|ref\|ZP_01969780.1\| hydroxyacylglutathione hydrolase GloB, putative [Vibrio cholerae NCT... gi\|153820855, gi... - gi\|229512116\|ref\|ZP_04401595.1\| hydroxyacylglutathione hydrolase [Vibrio cholerae B33], gi\|229352081... GLO2_VIBCH - Hydroxyacylglutathione hydrolase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N1... GLO2_VIBCH - Hydroxyacylglutathione hydrolase OS=Vibrio cholerae GN=gloB PE=3 SV=1	213.0	[0..57]	[319..1]
gi\|21070362 - gi\|21070362\|gb\|AAM34273.1\|AF508863_1 glyoxalase II [Pennisetum glaucum]	213.0	[0..1]	[319..1]
gi\|75856799, gi\|... - gi\|75856799\|ref\|ZP_00764422.1\| COG0491: Zn-dependent hydrolases, including glyoxylases [Vibrio sp. E...	213.0	[0..51]	[319..2]
gi\|110758324 - gi\|110758324\|ref\|XP_623458.2\| PREDICTED: similar to hydroxyacylglutathione hydrolase isoform 1 [Apis...	212.0	[0..58]	[321..34]
gi\|254225773, gi... - gi\|75820871\|ref\|ZP_00750909.1\| COG0491: Zn-dependent hydrolases, including glyoxylases [Vibrio chole...	212.0	[0..57]	[319..1]
CG4365-PC - This gene is referred to in FlyBase by the symbol Dmel\CG4365 (CG4365, FBgn0037024). It is a protein...	212.0	[0..57]	[321..89]

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Predicted Domain #1

Region A:
Residues: [1-322]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLKTLFSL NCLASVGFYK KFACKNLFFE NSFIRKDLHT YFIDKRKYFH LNKKDICTNT  60
   61 IIIPFYKDNY SYIFYDDKEE GIVVDPADYN IINDISKKEN IKIKHVLCTH KHSDHNNGNQ 120
  121 YYYEKNINVY GIKEYDNKYI NQDISNLTHF QINNFKINIF LSNFHSKNQV SYLIENDNNK 180
  181 SKKNIFFTGD FLFISGIGKN FEQDNEDLYN SINKLKLLDK QNIYIFCGHE YTLDNLKFAL 240
  241 TVDSTNKNLL SFYDHVVNSN KNYPTVPTLL EHEYLYNPFL RCDQNDVRKS IDLYAKKKNI 300
  301 KIQQESDYIV ILRLMKDNFK AS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.09691
Match:	1qh3A
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacylglutathione hydrolase activity	3.53012507604564	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
binding	0.900972948435178	bayes_pls_golite062009
thiolester hydrolase activity	0.802604883362264	bayes_pls_golite062009
hydrolase activity	0.021392930321391	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: