YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25286025
Organism:	Yersinia pestis
Length:	266 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25286025.

Description	E-value	Query Range	Subject Range
gi\|21957513, gi\|... - gi\|22124699\|ref\|NP_668122.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis KIM],...	0.0	[1..266]	[22..287]
PANB_YERPP - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yersinia pestis (strain Pestoides F) GN=panB PE=... PANB_YERPE - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yersinia pestis GN=panB PE=3 SV=2 PANB_YERPN - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN... PANB_YERPA - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=... gi\|165915465, gi... - gi\|165936816\|ref\|ZP_02225383.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|165990925, gi... - gi\|166010018\|ref\|ZP_02230916.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|166214114, gi... - gi\|166214114\|ref\|ZP_02240149.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|167398948, gi... - gi\|167398948\|ref\|ZP_02304472.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|167420531, gi... - gi\|167420531\|ref\|ZP_02312284.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|45440143, gi\|... - gi\|45440143\|ref\|NP_991682.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis biova... gi\|167423145, gi... - gi\|167423145\|ref\|ZP_02314898.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|167469892 - gi\|167469892\|ref\|ZP_02334596.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis FV... gi\|229695405, gi... - gi\|229839039\|ref\|ZP_04459198.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... gi\|229896518, gi... - gi\|229896518\|ref\|ZP_04511686.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis Pe... gi\|229899604, gi... - gi\|229899604\|ref\|ZP_04514745.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi... PANB_YERPG - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=p... gi\|161484866 - gi\|161484866\|ref\|NP_668122.2\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis KIM] gi\|165925856, gi... - gi\|165925856\|ref\|ZP_02221688.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pestis bi...	0.0	[2..266]	[1..265]
gi\|51595080, gi\|... - gi\|51595080\|ref\|YP_069271.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Yersinia pseudotuberc... PANB_YERPS - 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferas...	0.0	[1..266]	[1..266]
gi\|77957538, gi\|... - gi\|77957538\|ref\|ZP_00821591.1\| COG0413: Ketopantoate hydroxymethyltransferase [Yersinia bercovieri A...	0.0	[2..266]	[1..265]
gi\|238729348, gi... - gi\|77979584\|ref\|ZP_00835001.1\| COG0413: Ketopantoate hydroxymethyltransferase [Yersinia intermedia A...	0.0	[2..266]	[1..265]
gi\|77976054 - gi\|77976054\|ref\|ZP_00831587.1\| COG0413: Ketopantoate hydroxymethyltransferase [Yersinia frederikseni...	0.0	[2..266]	[1..265]
PANB_YERP3 - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strai...	0.0	[2..266]	[1..265]
gi\|238797185, gi... - gi\|77962795\|ref\|ZP_00826611.1\| COG0413: Ketopantoate hydroxymethyltransferase [Yersinia mollaretii A...	0.0	[2..266]	[1..265]
gi\|126175691, gi... - gi\|68543346\|ref\|ZP_00583054.1\| Ketopantoate hydroxymethyltransferase [Shewanella baltica OS155], gi\|... gi\|113948900, gi... - gi\|160874001\|ref\|YP_001553317.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Shewanella baltic... gi\|151363999, gi... - gi\|152999381\|ref\|YP_001365062.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Shewanella baltic... gi\|149116833, gi... - gi\|217972058\|ref\|YP_002356809.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Shewanella baltic...	0.0	[2..265]	[1..263]
SO0870 - 3-methyl-2-oxobutanoate hydroxymethyltransferase PANB_SHEON - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Shewanella oneidensis (strain MR-1) GN=panB PE=3...	0.0	[2..265]	[1..263]

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Predicted Domain #1

Region A:
Residues: [1-266]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKTTTMSQL RQWKQEKRKF ATLTAYDASF AQLFAEQGIQ VLLVGDSLGM TLQGFDSTLP  60
   61 VTVADMAYHT RAVRRGAPHC LLLADMPFMS YATPELAFTH AAELMRAGAN MVKLEGGSWL 120
  121 CDTIRMLAER AVPVCGHLGL TPQSVNIFGG YKVQGREEVA ANQLLQDAIA LEQAGAQLLV 180
  181 LECVPVELAQ RVTEELTIPV IGIGAGNVTD GQILVMHDAL GITGGHTPKF SKNFLAHSAG 240
  241 DIRAAIKLYI EEVEGGIYPA EEHTFQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	117.0
Match:	1m3uA
Description:	Ketopantoate hydroxymethyltransferase PanB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-methyl-2-oxobutanoate hydroxymethyltransferase activity	4.08693637310631	bayes_pls_golite062009
catalytic activity	2.59838799615646	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	2.05689968523792	bayes_pls_golite062009
transferase activity	1.07154136609184	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.646649320021871	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.366715189574293	bayes_pls_golite062009
oxo-acid-lyase activity	0.0960362356555544	bayes_pls_golite062009
carbon-carbon lyase activity	0.0846611486307003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: