YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|45441670, gi\|...
Organism:	Yersinia pestis biovar Microtus str. 91001
Length:	276 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|45441670, gi|....

Description	E-value	Query Range	Subject Range
gi\|77973499 - gi\|77973499\|ref\|ZP_00829046.1\| COG2890: Methylase of polypeptide chain release factors [Yersinia fre...	2.0E-52	[1..276]	[1..276]
gi\|77963727 - gi\|77963727\|ref\|ZP_00827535.1\| COG2890: Methylase of polypeptide chain release factors [Yersinia mol...	3.0E-51	[1..275]	[1..275]
gi\|186895375, gi... - gi\|186895375\|ref\|YP_001872487.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Y... gi\|169750943, gi... - gi\|170024409\|ref\|YP_001720914.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Y... Q66AX4\|Q66AX4_YERPS - Putative protoporphyrinogen oxidase - Yersinia pseudotuberculosis gi\|51596332, gi\|... - gi\|51596332\|ref\|YP_070523.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Yersi...	3.0E-51	[1..276]	[1..276]
gi\|153948102, gi... - gi\|77629090\|ref\|ZP_00791676.1\| COG2890: Methylase of polypeptide chain release factors [Yersinia pse...	4.0E-51	[1..276]	[1..276]
gi\|196113152, gi... - gi\|88796062\|ref\|ZP_01111746.1\| peptide release factor-glutamine N5-methyltransferase [Alteromonas ma...	7.0E-51	[1..274]	[1..284]
gi\|49611644, gi\|... - gi\|50121118\|ref\|YP_050285.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Pecto...	7.0E-50	[1..274]	[1..275]
gi\|37525988, gi\|... - gi\|37525988\|ref\|NP_929332.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Photo...	1.0E-49	[1..274]	[1..275]
gi\|219681546, gi... - gi\|219681546\|ref\|YP_002467931.1\| HemK protein [Buchnera aphidicola str. 5A (Acyrthosiphon pisum)], g... HEMK_BUCAI - Protein hemK homolog OS=Buchnera aphidicola subsp. Acyrthosiphon pisum GN=hemK PE=3 SV=1 gi\|257471229\|ref... - HemK protein [Buchnera aphidicola str. LSR1 (Acyrthosiphon pisum)] PRMC_BUCAI - Release factor glutamine methyltransferase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum (strain... gi\|25403559 - gi\|25403559\|pir\|\|A84950 hemK protein [imported] - Buchnera sp. (strain APS)	1.0E-49	[1..274]	[1..274]
lcl\|NC_016856.1_... - [gene=hemK] [protein=N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase] [protein_id=Y... gi\|206708521, gi... - gi\|207856718\|ref\|YP_002243369.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|224583735, gi... - gi\|224583735\|ref\|YP_002637533.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... HEMK_SALTY - Protein methyltransferase hemK OS=Salmonella typhimurium GN=hemK PE=3 SV=2 gi\|194443667, gi... - gi\|194443667\|ref\|YP_002041025.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|194735200, gi... - gi\|194735200\|ref\|YP_002114805.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|197243898, gi... - gi\|197265643\|ref\|ZP_03165717.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [S... gi\|197939950, gi... - gi\|198245434\|ref\|YP_002215370.1\| protein methyltransferase HemK [Salmonella enterica subsp. enterica... gi\|161363093, gi... - gi\|161613729\|ref\|YP_001587694.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|167993218, gi... - gi\|205328672\|gb\|EDZ15436.1\| protein methyltransferase HemK [Salmonella enterica subsp. enterica sero... gi\|197289229, gi... - gi\|197289229\|gb\|EDY28596.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Salmo... gi\|205342641, gi... - gi\|205342641\|gb\|EDZ29405.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Salmo... PRMC_SALTY - Release factor glutamine methyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7... PRMC_SALTY, HEMK... - Release factor glutamine methyltransferase OS=Salmonella typhimurium GN=prmC PE=3 SV=2, Protein meth... gi\|62127972, gi\|... - gi\|62180339\|ref\|YP_216756.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmo...	1.0E-49	[1..274]	[1..275]
gi\|194423947, gi... - gi\|83587356\|ref\|ZP_00925984.1\| COG2890: Methylase of polypeptide chain release factors [Escherichia ... gi\|251784718, gi... - gi\|251784718\|ref\|YP_002999022.1\| hypothetical protein B21_01197 [Escherichia coli BL21], gi\|24237699... gi\|253973195, gi... - gi\|254161294\|ref\|YP_003044402.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [E... gi\|253977409, gi... - gi\|254288102\|ref\|YP_003053850.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [E...	1.0E-49	[1..274]	[1..275]

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Predicted Domain #1

Region A:
Residues: [1-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYQHWLSLA AARFTHSDSP KRDAEILLSF VTGKARTYLL AFGETEITAE QLLWLETLAN  60
   61 RREQGEPIAY LVGEREFWSL PLSVSSATLI PRPDTECLVE QALARLPAMP CRILDLGTGT 120
  121 GAIALALATE RRDCAVIAVD INADAVALAR HNAEKLTIDN VCFLQGSWFE PVSGRFALIA 180
  181 SNPPYIDAND PHLNEGDVRY EPHSALVAAA EGMADLAAIV SQAPGYLDPG GWLMLEHGWQ 240
  241 QANAVQELLK NSGFSAVMTC KDYGNNDRVT LGQWAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.30103
Match:	1t43A
Description:	Crystal Structure Analysis of E.coli Protein (N5)-Glutamine Methyltransferase (HemK)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-adenosylmethionine-dependent methyltransferase activity	4.81722723955895	bayes_pls_golite062009
methyltransferase activity	4.64500705012502	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.57389022626587	bayes_pls_golite062009
DNA-methyltransferase activity	3.31632172292823	bayes_pls_golite062009
N-methyltransferase activity	3.00112136063228	bayes_pls_golite062009
protein methyltransferase activity	2.74535979387581	bayes_pls_golite062009
transferase activity	2.42370637689376	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	2.17404404470337	bayes_pls_golite062009
catalytic activity	1.62377578202456	bayes_pls_golite062009
histone methyltransferase activity	1.42140847541194	bayes_pls_golite062009
arginine N-methyltransferase activity	1.40233857644962	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.40233857644962	bayes_pls_golite062009
RNA methyltransferase activity	1.36067005317038	bayes_pls_golite062009
rRNA methyltransferase activity	0.740099749645209	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	0.67380437956274	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	0.6110460718981	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.355464145533041	bayes_pls_golite062009
O-methyltransferase activity	0.32686871890222	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.255084448603261	bayes_pls_golite062009
binding	0.207713650201315	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.11336280953361	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: