YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|25298451
Organism:	Yersinia pestis
Length:	458 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25298451.

Description	E-value	Query Range	Subject Range
gi\|218540301, gi... - gi\|218848250\|ref\|YP_002455135.1\| sensor histidine kinase [Bacillus cereus AH820], gi\|218540301\|gb\|AC... gi\|229164673, gi... - gi\|229164673\|ref\|ZP_04292537.1\| hypothetical protein bcere0009_53880 [Bacillus cereus R309803], gi\|2... gi\|116585027, gi... - gi\|190015346\|ref\|YP_001967073.1\| sensor histidine kinase [Bacillus cereus], gi\|190015080\|ref\|YP_0019... gi\|44004552, gi\|... - gi\|44004552\|ref\|NP_982221.1\| sensor histidine kinase [Bacillus cereus ATCC 10987], gi\|42741618\|gb\|AA...	1.0E-69	[2..451]	[1..453]
gi\|20808918 - gi\|20808918\|ref\|NP_624089.1\| Sensory transduction histidine kinase [Thermoanaerobacter tengcongensis... gi\|20808918, gi\|... - gi\|20808918\|ref\|NP_624089.1\| sensory transduction histidine kinase [Thermoanaerobacter tengcongensis...	8.0E-69	[2..456]	[3..469]
gi\|49331784, gi\|... - gi\|49480228\|ref\|YP_034908.1\| sensor histidine kinase [Bacillus thuringiensis serovar konkukian str. ...	1.0E-68	[2..452]	[1..454]
gi\|167635201, gi... - gi\|167635201\|ref\|ZP_02393517.1\| sensor histidine kinase [Bacillus anthracis str. A0442], gi\|16752946... gi\|165872713, gi... - gi\|165872713\|ref\|ZP_02217342.1\| sensor histidine kinase [Bacillus anthracis str. A0488], gi\|16471157... gi\|170667007, gi... - gi\|170689022\|ref\|ZP_02880222.1\| sensor histidine kinase [Bacillus anthracis str. A0465], gi\|17066700... gi\|167511106, gi... - gi\|167640886\|ref\|ZP_02399144.1\| sensor histidine kinase [Bacillus anthracis str. A0193], gi\|16751110... gi\|177652843, gi... - gi\|177652843\|ref\|ZP_02935216.1\| sensor histidine kinase [Bacillus anthracis str. A0174], gi\|17208187... gi\|170708472, gi... - gi\|170708472\|ref\|ZP_02898914.1\| sensor histidine kinase [Bacillus anthracis str. A0389], gi\|17012659... gi\|49177569, gi\|... - gi\|49183642\|ref\|YP_026894.1\| sensor histidine kinase [Bacillus anthracis str. Sterne], gi\|49177569\|g... gi\|227816480, gi... - gi\|227816480\|ref\|YP_002816489.1\| sensor histidine kinase [Bacillus anthracis str. CDC 684], gi\|22700... gi\|47525929, gi\|... - gi\|47525929\|ref\|YP_017278.1\| sensor histidine kinase [Bacillus anthracis str. 'Ames Ancestor'], gi\|4... gi\|229266529, gi... - gi\|229602121\|ref\|YP_002865248.1\| sensor histidine kinase [Bacillus anthracis str. A0248], gi\|2292665... gi\|30254253, gi\|... - gi\|30260804\|ref\|NP_843181.1\| sensor histidine kinase [Bacillus anthracis str. Ames], gi\|30254253\|gb\|... gi\|254684273 - gi\|254684273\|ref\|ZP_05148133.1\| sensor histidine kinase [Bacillus anthracis str. CNEVA-9066] gi\|21398611, gi\|... - gi\|65318076\|ref\|ZP_00391035.1\| COG0642: Signal transduction histidine kinase [Bacillus anthracis str... gi\|254722077 - gi\|254722077\|ref\|ZP_05183866.1\| sensor histidine kinase [Bacillus anthracis str. A1055] gi\|254738738 - gi\|254738738\|ref\|ZP_05196441.1\| sensor histidine kinase [Bacillus anthracis str. Western North Ameri... gi\|254742050 - gi\|254742050\|ref\|ZP_05199737.1\| sensor histidine kinase [Bacillus anthracis str. Kruger B] gi\|254754963 - gi\|254754963\|ref\|ZP_05206997.1\| sensor histidine kinase [Bacillus anthracis str. Vollum] gi\|190568579, gi... - gi\|190568579\|ref\|ZP_03021485.1\| sensor histidine kinase [Bacillus anthracis Tsiankovskii-I], gi\|1905... gi\|254762306 - gi\|254762306\|ref\|ZP_05214150.1\| sensor histidine kinase [Bacillus anthracis str. Australia 94]	2.0E-68	[2..452]	[1..454]
gi\|77977377 - gi\|77977377\|ref\|ZP_00832827.1\| COG0642: Signal transduction histidine kinase [Yersinia intermedia AT...	3.0E-68	[1..458]	[1..458]
gi\|152974373, gi... - gi\|89203396\|ref\|ZP_01182066.1\| ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidi...	4.0E-68	[2..458]	[1..460]
gi\|51978130, gi\|... - gi\|52144661\|ref\|YP_082167.1\| sensor histidine kinase [Bacillus cereus E33L], gi\|51978130\|gb\|AAU19680...	6.0E-68	[2..452]	[1..454]
gi\|77960031 - gi\|77960031\|ref\|ZP_00823931.1\| COG0642: Signal transduction histidine kinase [Yersinia mollaretii AT...	1.0E-67	[1..458]	[1..458]
gi\|228640184, gi... - gi\|229143377\|ref\|ZP_04271808.1\| hypothetical protein bcere0012_5490 [Bacillus cereus BDRD-ST24], gi\|... gi\|228657404, gi... - gi\|229126082\|ref\|ZP_04255104.1\| hypothetical protein bcere0015_5450 [Bacillus cereus BDRD-Cer4], gi\|... gi\|29894376, gi\|... - gi\|30018834\|ref\|NP_830465.1\| two component system histidine kinase [Bacillus cereus ATCC 14579], gi\|...	1.0E-67	[2..452]	[1..454]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINSLTTRIF AIFWFTLALV LMLVLMVPKL DSRQLTVLLD SEQRQGTMLE QHIEAELAND  60
   61 PANDLMWWRR LHRAIEKWAP PGQHLILVTS EGRIIGVQRQ EVQMVRNFIG QS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.505	0.979	two-component sensor activity	d.110.3	PYP-like sensor domain (PAS domain)
View	Download	0.520	0.979	two-component sensor activity	d.150.1	4'-phosphopantetheinyl transferase
View	Download	0.559	0.979	two-component sensor activity	a.73.1	Retrovirus capsid protein, N-terminal core domain
View	Download	0.776	0.979	two-component sensor activity	d.39.1	Dynein light chain 8 (DLC8)
View	Download	0.520	0.979	two-component sensor activity	a.24.4	Hemerythrin

Predicted Domain #2

Region A:
Residues: [113-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNADQPKKKK YGRVEMVGPF SIRDGEDNYQ LYLIRPANSP QSDFINLMFD RPLLLLIATM  60
   61 LISAPLLLWL AWSLAKPARK LKNAADDVAR GNLKQHPELE S

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.15
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [214-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPQEFLATGA SFNQMISSLD RMVVAQQRLI SDISHELRTP LTRLQLATAL MRRRHGEGKE  60
   61 LERIEMEAQR LDSMINDLLV LSRSQHKNEL HREPIKADEL WSDVLENAQF EAEQMGKTLV 120
  121 VTAPPGPWPL FCNPAALDSA LENIVRNALR YSHHHIAVAF SIDNQGVTII VDDDGPGVSP 180
  181 EDREQIFRPF YRTDEARDRA SGGTGLGLAI VETAVSQHRG WVKAEDSPLG GLRLIVWLPL 240
  241 HPLKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.69897
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits