YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|15827681
Organism:	Mycobacterium leprae TN
Length:	281 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|15827681.

Description	E-value	Query Range	Subject Range
gi\|466999, gi\|21... - gi\|466999\|gb\|AAA17184.1\| pimT; B2126_C1_165 [Mycobacterium leprae], pir\|\|S72844 beta-aspartate methy...	206.0	[0..1]	[281..1]
gi\|90206141, gi\|... - gi\|90206141\|ref\|ZP_01208777.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium vanbaalenii PYR...	200.0	[0..1]	[281..1]
gi\|31618890, gi\|... - gi\|31793298\|ref\|NP_855791.1\| RNA methyltransferase [Mycobacterium bovis AF2122/97], gi\|31618890\|emb\|... gi\|215403502 - gi\|215403502\|ref\|ZP_03415683.1\| RNA methyltransferase [Mycobacterium tuberculosis 02_1987] TRMI_MYCTU - tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis GN=trmI PE=1 SV=1 TRMI_MYCTO - tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshk... gi\|215427494 - gi\|215427494\|ref\|ZP_03425413.1\| RNA methyltransferase [Mycobacterium tuberculosis T92] TRMI_MYCTU - tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis (strain ATCC 25618 / H3... gi\|121493648, gi... - gi\|121638000\|ref\|YP_978224.1\| putative RNA methyltransferase [Mycobacterium bovis BCG str. Pasteur 1... gi\|215411822 - gi\|215411822\|ref\|ZP_03420614.1\| RNA methyltransferase [Mycobacterium tuberculosis 94_M4241A] gi\|194544330, gi... - gi\|81253912\|ref\|ZP_00878442.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyl... gi\|215446343 - gi\|215446343\|ref\|ZP_03433095.1\| RNA methyltransferase [Mycobacterium tuberculosis T85] gi\|215431042 - gi\|215431042\|ref\|ZP_03428961.1\| RNA methyltransferase [Mycobacterium tuberculosis EAS054] gi\|224773607, gi... - gi\|224990494\|ref\|YP_002645181.1\| putative RNA methyltransferase [Mycobacterium bovis BCG str. Tokyo ... gi\|218753840 - gi\|218753840\|ref\|ZP_03532636.1\| RNA methyltransferase [Mycobacterium tuberculosis GM 1503] gi\|253320323, gi... - gi\|253798820\|ref\|YP_003031821.1\| RNA methyltransferase [Mycobacterium tuberculosis KZN 1435], gi\|253... gi\|254551150 - gi\|254551150\|ref\|ZP_05141597.1\| RNA methyltransferase [Mycobacterium tuberculosis '98-R604 INH-RIF-E... gi\|254815934 - gi\|254815934\|ref\|ZP_05220935.1\| putative RNA methyltransferase [Mycobacterium tuberculosis KZN 4207] gi\|255096921 - gi\|255096921\|ref\|ZP_05326399.1\| putative RNA methyltransferase [Mycobacterium tuberculosis KZN 605] gi\|254364925, gi... - gi\|254364925\|ref\|ZP_04980971.1\| hypothetical RNA methyltransferase [Mycobacterium tuberculosis str. ... gi\|148661933, gi... - gi\|167967472\|ref\|ZP_02549749.1\| hypothetical RNA methyltransferase [Mycobacterium tuberculosis H37Ra... gi\|148721856, gi... - gi\|76784001\|ref\|ZP_00771188.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyl...	199.0	[0..1]	[281..1]
gi\|41407940, gi\|... - gi\|41407940\|ref\|NP_960776.1\| hypothetical protein MAP1842c [Mycobacterium avium subsp. paratuberculo...	199.0	[0..1]	[281..1]
gi\|19552712, gi\|... - gi\|62390380\|ref\|YP_225782.1\| SAM-dependent methyltransferase involved in tRNA-Met maturation [Coryne...	199.0	[0..1]	[281..1]
gi\|71915941, gi\|... - gi\|72162209\|ref\|YP_289866.1\| tRNA (adenine-58-N(1)-) methyltransferase [Thermobifida fusca YX], gi\|7... gi\|48837251 - ref\|ZP_00294246.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyltransferases...	194.0	[0..3]	[279..7]
gi\|21220147, gi\|... - gi\|6119693\|emb\|CAB59504.1\| conserved hypothetical protein SCI41.34c [Streptomyces coelicolor A3(2)],...	193.0	[0..3]	[279..10]
gi\|108770521, gi... - gi\|108800102\|ref\|YP_640299.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium sp. MCS], gi\|108... gi\|119869230, gi... - gi\|92916456\|ref\|ZP_01285075.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium sp. KMS], gi\|92... gi\|126435727, gi... - gi\|92907942\|ref\|ZP_01276721.1\| tRNA (adenine-N(1)-)-methyltransferase [Mycobacterium sp. JLS], gi\|92...	193.0	[0..1]	[281..1]
gi\|3790599 - gi\|3790599\|gb\|AAC68688.1\| unknown [Rhodococcus erythropolis]	193.0	[0..4]	[280..43]
gi\|38233837 - gi\|38233837\|ref\|NP_939604.1\| hypothetical protein DIP1249 [Corynebacterium diphtheriae NCTC 13129] gi\|38200098 - gi\|38200098\|emb\|CAE49778.1\| Conserved hypothetical protein [Corynebacterium diphtheriae]	193.0	[0..1]	[281..1]

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Predicted Domain #1

Region A:
Residues: [1-281]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATGPFTVG ERVQLTDTKG RHYTMSLTPG GEFHTHRGSI AHDGIIGLEQ GSVVKSSTGA  60
   61 LFLVLRPLLI DYVMSMPRGP QVIYPKDAAQ IVHEGDIFPG ARVLEAGAGS GALTCSLLRA 120
  121 VGPQGQVISY ELRTDHAEHA RRNVSNFFCV SGAEGRLSDN WQLIVSDVAN SELPDGSVDR 180
  181 VVLDMLAPWE VLDTVSRLVI AGGVLVIYVA TVTQLSRAVE ALRVQQCWVE PRAWETLQRG 240
  241 WNVVGLAVRP EHLMRGHTAF LILARRLAPG AVAPAPWGRK R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.221849
Match:	1i9gA
Description:	Probable methyltransferase Rv2118c
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
N-methyltransferase activity	3.0539218951403	bayes_pls_golite062009
protein methyltransferase activity	3.01384869242051	bayes_pls_golite062009
rRNA methyltransferase activity	2.29640050660273	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
tRNA methyltransferase activity	1.95598912777096	bayes_pls_golite062009
histone methyltransferase activity	1.90505369820945	bayes_pls_golite062009
DNA-methyltransferase activity	1.63765148226572	bayes_pls_golite062009
arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.05897361334523	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	0.966788807255255	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	0.966788807255255	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	0.778520793236291	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	0.778520793236291	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.639377525568296	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.533090627724779	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.455449410561251	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.130104080746388	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.130042730841119	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: