YRC Public Data Repository - Protein Structure Prediction

Protein:	OTSB_MYCLE
Organism:	Mycobacterium leprae TN
Length:	429 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OTSB_MYCLE.

Description	E-value	Query Range	Subject Range
gi\|115367658, gi... - gi\|115375374\|ref\|ZP_01462637.1\| beta-phosphoglucomutase hydrolase [Stigmatella aurantiaca DW4/3-1], ...	266.0	[0..3]	[429..108]
gi\|120606588, gi... - gi\|121594508\|ref\|YP_986404.1\| beta-phosphoglucomutase family hydrolase [Acidovorax sp. JS42], gi\|120...	250.0	[0..9]	[427..115]
gi\|120405061, gi... - gi\|90203065\|ref\|ZP_01205711.1\| HAD-superfamily hydrolase subfamily IIB [Mycobacterium vanbaalenii PY...	232.0	[0..1]	[424..3]
gi\|207090853 - gi\|207090853\|gb\|EDZ68124.1\| trehalose-phosphatase, putative [Nitrosococcus oceani AFC27] gi\|254434520, gi... - gi\|254434520\|ref\|ZP_05048028.1\| trehalose-phosphatase, putative [Nitrosococcus oceani AFC27], gi\|224... gi\|77165252, gi\|... - gi\|77165252\|ref\|YP_343777.1\| Beta-phosphoglucomutase hydrolase [Nitrosococcus oceani ATCC 19707], gi...	225.0	[0..9]	[427..103]
gi\|253800419, gi... - gi\|253800419\|ref\|YP_003033420.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis... gi\|254552474 - gi\|254552474\|ref\|ZP_05142921.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... gi\|134151500, gi... - gi\|254365987\|ref\|ZP_04982032.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... gi\|215432342 - gi\|215432342\|ref\|ZP_03430261.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... gi\|254814341 - gi\|254814341\|ref\|ZP_05219342.1\| putative trehalose 6-phosphate phosphatase [Mycobacterium tuberculos... OTSB_MYCTA - Trehalose-phosphate phosphatase OS=Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) GN=otsB PE... gi\|215428876 - gi\|215428876\|ref\|ZP_03426795.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... gi\|255095317 - gi\|255095317\|ref\|ZP_05324795.1\| putative trehalose 6-phosphate phosphatase [Mycobacterium tuberculos... gi\|218755150 - gi\|218755150\|ref\|ZP_03533946.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... OTSB_MYCBO - Trehalose-phosphate phosphatase OS=Mycobacterium bovis GN=otsB PE=3 SV=1 gi\|215447694 - gi\|215447694\|ref\|ZP_03434446.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... gi\|224991796, gi... - gi\|224991796\|ref\|YP_002646485.1\| putative trehalose 6-phosphate phosphatase [Mycobacterium bovis BCG... gi\|219559447 - gi\|219559447\|ref\|ZP_03538523.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... OTSB_MYCBP - Trehalose-phosphate phosphatase OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) GN=otsB PE=3 SV... gi\|76782756, gi\|... - gi\|76782756\|ref\|ZP_00769952.1\| COG1877: Trehalose-6-phosphatase [Mycobacterium tuberculosis F11], gi... gi\|81251887, gi\|... - gi\|81251887\|ref\|ZP_00876499.1\| COG1877: Trehalose-6-phosphatase [Mycobacterium tuberculosis C], gi\|2... gi\|215413271 - gi\|215413271\|ref\|ZP_03421960.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... gi\|215405392 - gi\|215405392\|ref\|ZP_03417573.1\| trehalose 6-phosphate phosphatase otsB2 [Mycobacterium tuberculosis ... OTSB_MYCBO - Trehalose-phosphate phosphatase OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) GN=otsB PE=... OTSB_MYCTU - Trehalose-phosphate phosphatase OS=Mycobacterium tuberculosis GN=otsB PE=1 SV=1 OTSB_MYCTO - Trehalose-phosphate phosphatase OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=otsB PE... OTSB_MYCTU - Trehalose-phosphate phosphatase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=otsB PE...	216.0	[0..2]	[428..6]
gi\|91202290 - gi\|91202290\|emb\|CAJ75350.1\| conserved hypothetical protein [Candidatus Kuenenia stuttgartiensis]	215.0	[0..8]	[421..3]
TPPD_ARATH - Probable trehalose-phosphate phosphatase D OS=Arabidopsis thaliana GN=TPPD PE=2 SV=1	213.0	[0..116]	[429..52]

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Predicted Domain #1

Region A:
Residues: [1-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVTIDPRRH SAALFDLDAV VTDTPLDSTV TLVRQLQGIG VGTAVFSTNR NSQGVLTATG  60
   61 LDHLFPVHVD GLASGKVTIL VAAANRLMAQ PGRCVVVAVD AAGITAARYG GFALVLGLVI 120
  121 GEDQTGHRDT LRNSGADTVV ADLGEVIVRT GDRRMSELPD AL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.0
Match:	1swvA
Description:	Crystal structure of the D12A mutant of phosphonoacetaldehyde hydrolase complexed with magnesium
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.92340854382984	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [163-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTLGLTDDLT ARQPAVFFDF DGTLSDIVDD PDSARPVPGA TEALQKLATH CPVAILSGRD  60
   61 LADVIKRIGV PGIWYSGSHG FESTAPDGTH HQNDAAEATI PILEQAATQL RDQLGPIPGV 120
  121 MVEHKRFGVA VHYRNVARDR VNEVAVAVRT AGQRNALRVT TGREVIELRP DIDWDKGKTL 180
  181 HWVIDRLHHA GTQVGSASLM PICLGDDITD EDAFDAVRHT DVGGIPIVVR HTEDGNRATA 240
  241 ALFTLDSPMH VSEFTERLAR QLSDTQR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.221849
Match:	1u02A
Description:	Crystal structure of trehalose-6-phosphate phosphatase related protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.92340854382984	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: