YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|29140300, gi\|...
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. Ty2
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|29140300, gi|....

Description	E-value	Query Range	Subject Range
gi\|62182809, gi\|... - gi\|62182809\|ref\|YP_219226.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica serov... gi\|194735493, gi... - gi\|194735493\|ref\|YP_002117304.1\| HflK protein [Salmonella enterica subsp. enterica serovar Schwarzen... gi\|197263245, gi... - gi\|197263245\|ref\|ZP_03163319.1\| HflK protein [Salmonella enterica subsp. enterica serovar Saintpaul ... gi\|194448275, gi... - gi\|194448275\|ref\|YP_002048406.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|56130411, gi\|... - gi\|56416154\|ref\|YP_153229.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica serov... gi\|194458469, gi... - gi\|194472105\|ref\|ZP_03078089.1\| HflK protein [Salmonella enterica subsp. enterica serovar Kentucky s... gi\|205348006, gi... - gi\|205348006\|gb\|EDZ34637.1\| HflK protein [Salmonella enterica subsp. enterica serovar Hadar str. RI_... gi\|194442767, gi... - gi\|194442767\|ref\|YP_002043618.1\| HflK protein [Salmonella enterica subsp. enterica serovar Newport s... gi\|197287604, gi... - gi\|197287604\|gb\|EDY26996.1\| HflK protein [Salmonella enterica subsp. enterica serovar Schwarzengrund... gi\|205336314, gi... - gi\|205336314\|gb\|EDZ23078.1\| HflK protein [Salmonella enterica subsp. enterica serovar Heidelberg str... gi\|238910521 - gi\|238910521\|ref\|ZP_04654358.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica se... gi\|205321597, gi... - gi\|205321597\|gb\|EDZ09436.1\| HflK protein [Salmonella enterica subsp. enterica serovar Saintpaul str.... gi\|205334375, gi... - gi\|205334375\|gb\|EDZ21139.1\| HflK protein [Salmonella enterica subsp. enterica serovar Kentucky str. ... lcl\|NC_016856.1_... - [gene=hflK] [protein=FtsH protease regulator HflK] [protein_id=YP_005240675.1] [location=4619281..46... gi\|16422924, gi\|... - gi\|16767609\|ref\|NP_463224.1\| FtsH protease regulator HflK [Salmonella typhimurium LT2], gi\|16422924\|... gi\|207859509, gi... - gi\|207859509\|ref\|YP_002246160.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|224586203, gi... - gi\|224586203\|ref\|YP_002640002.1\| HflK protein [Salmonella enterica subsp. enterica serovar Paratyphi... gi\|204926789, gi... - gi\|204926789\|ref\|ZP_03217991.1\| HflK protein [Salmonella enterica subsp. enterica serovar Javiana st... gi\|205274902, gi... - gi\|205355121\|ref\|YP_002228922.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|197365080, gi... - gi\|197365080\|ref\|YP_002144717.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|199604980, gi... - gi\|200387882\|ref\|ZP_03214494.1\| HflK protein [Salmonella enterica subsp. enterica serovar Virchow st...	9.0E-87	[1..419]	[1..419]
gi\|82779444, gi\|... - gi\|82779444\|ref\|YP_405793.1\| FtsH protease regulator HflK [Shigella dysenteriae Sd197], gi\|81243592\|...	6.0E-86	[1..419]	[1..419]
gi\|91075297, gi\|... - gi\|91213723\|ref\|YP_543709.1\| FtsH protease regulator HflK [Escherichia coli UTI89], gi\|91075297\|gb\|A... gi\|117626521, gi... - gi\|117626521\|ref\|YP_859844.1\| FtsH protease regulator HflK [Escherichia coli APEC O1], gi\|115515645\|... gi\|226901753, gi... - gi\|237703841\|ref\|ZP_04534322.1\| FtsH protease regulator HflK [Escherichia sp. 3_2_53FAA], gi\|2269017... gi\|218368102, gi... - gi\|218561333\|ref\|YP_002394246.1\| FtsH protease regulator HflK [Escherichia coli S88], gi\|218368102\|e...	7.0E-86	[1..419]	[1..419]
gi\|110644531, gi... - gi\|110644531\|ref\|YP_672261.1\| FtsH protease regulator HflK [Escherichia coli 536], gi\|110346123\|gb\|A... gi\|218692508, gi... - gi\|218692508\|ref\|YP_002400720.1\| FtsH protease regulator HflK [Escherichia coli ED1a], gi\|218430072\|... gi\|170520346, gi... - gi\|170682628\|ref\|YP_001746569.1\| HflK protein [Escherichia coli SMS-3-5], gi\|170520346\|gb\|ACB18524.1... gi\|218372857, gi... - gi\|218702871\|ref\|YP_002410500.1\| FtsH protease regulator HflK [Escherichia coli IAI39], gi\|218372857... gi\|190905198, gi... - gi\|75242437\|ref\|ZP_00726199.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|26251066, gi\|... - gi\|26251066\|ref\|NP_757106.1\| FtsH protease regulator HflK [Escherichia coli CFT073], gi\|26111498\|gb\|... gi\|227836356, gi... - gi\|227886783\|ref\|ZP_04004588.1\| FtsH protease regulator HflK [Escherichia coli 83972], gi\|227836356\|...	8.0E-86	[1..419]	[1..419]
gi\|15834404, gi\|... - gi\|15834404\|ref\|NP_313177.1\| FtsH protease regulator HflK [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|110617640, gi... - gi\|110808092\|ref\|YP_691612.1\| FtsH protease regulator HflK [Shigella flexneri 5 str. 8401], gi\|11061... gi\|194439534, gi... - gi\|83585088\|ref\|ZP_00923741.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|208740125, gi... - gi\|208820002\|ref\|ZP_03260322.1\| HflK protein [Escherichia coli O157:H7 str. EC4042], gi\|208740125\|gb... HFLK_ECO57 - Protein HflK OS=Escherichia coli O157:H7 GN=hflK PE=3 SV=1 gi\|208734202, gi... - gi\|208812925\|ref\|ZP_03254254.1\| HflK protein [Escherichia coli O157:H7 str. EC4045], gi\|208734202\|gb... EG10436 - modulator for HflB protease specific for phage lambda cII repressor / Membrane bound protease comple... gi\|209921662, gi... - gi\|209921662\|ref\|YP_002295746.1\| FtsH protease regulator HflK [Escherichia coli SE11], gi\|209914921\|... gi\|12519159, gi\|... - gi\|15804763\|ref\|NP_290804.1\| FtsH protease regulator HflK [Escherichia coli O157:H7 EDL933], gi\|1251... gi\|209161196, gi... - gi\|209399796\|ref\|YP_002273716.1\| HflK protein [Escherichia coli O157:H7 str. EC4115], gi\|209161196\|g... gi\|218556726, gi... - gi\|218556726\|ref\|YP_002389640.1\| FtsH protease regulator HflK [Escherichia coli IAI1], gi\|218363495\|... gi\|217324163, gi... - gi\|217324163\|ref\|ZP_03440247.1\| HflK protein [Escherichia coli O157:H7 str. TW14588], gi\|217320384\|g... EG10436 - modulator for HflB protease specific for phage lambda cII repressor / Membrane bound protease comple... gi\|218707785, gi... - gi\|218707785\|ref\|YP_002415304.1\| FtsH protease regulator HflK [Escherichia coli UMN026], gi\|21843488... HFLK_ECOLI - Protein hflK - Escherichia coli gi\|124500675, gi... - gi\|124528233\|ref\|ZP_01699557.1\| HflK protein [Escherichia coli B], gi\|124500675\|gb\|EAY48145.1\| HflK ... gi\|238861786, gi... - gi\|238903281\|ref\|YP_002929077.1\| modulator for HflB protease specific for phage lambda cII repressor... gi\|242379696, gi... - gi\|251787423\|ref\|YP_003001727.1\| hypothetical protein B21_04003 [Escherichia coli BL21], gi\|24237969... gi\|254290853, gi... - gi\|254290853\|ref\|YP_003056601.1\| modulator for HflB protease specific for phage lambda cII repressor... gi\|226840294, gi... - gi\|254037188\|ref\|ZP_04871265.1\| HflK protein [Escherichia sp. 1_1_43], gi\|226840294\|gb\|EEH72296.1\| H... gi\|254164103, gi... - gi\|254164103\|ref\|YP_003047211.1\| modulator for HflB protease specific for phage lambda cII repressor... gi\|254595593, gi... - gi\|254796193\|ref\|YP_003081030.1\| modulator for HflB protease specific for phage lambda cII repressor... gi\|168784809, gi... - gi\|189375095\|gb\|EDU93511.1\| HflK protein [Escherichia coli O157:H7 str. EC869], gi\|168784809\|ref\|ZP_... gi\|168780604, gi... - gi\|189001651\|gb\|EDU70637.1\| HflK protein [Escherichia coli O157:H7 str. EC4076], gi\|168780604\|ref\|ZP... gi\|170021816, gi... - gi\|170021816\|ref\|YP_001726770.1\| FtsH protease regulator HflK [Escherichia coli ATCC 8739], gi\|16975... gi\|189376081, gi... - gi\|189376081\|gb\|EDU94497.1\| HflK protein [Escherichia coli O157:H7 str. EC508], gi\|168801827\|ref\|ZP_... gi\|194434592, gi... - gi\|194434592\|ref\|ZP_03066849.1\| HflK protein [Shigella dysenteriae 1012], gi\|194417177\|gb\|EDX33289.1... gi\|169891455, gi... - gi\|170083620\|ref\|YP_001732940.1\| modulator for HflB protease specific for phage lambda cII repressor... gi\|208727464, gi... - gi\|208807663\|ref\|ZP_03250000.1\| HflK protein [Escherichia coli O157:H7 str. EC4206], gi\|208727464\|gb... gi\|195935964 - gi\|195935964\|ref\|ZP_03081346.1\| FtsH protease regulator HflK [Escherichia coli O157:H7 str. EC4024] gi\|157163637, gi... - gi\|75198020\|ref\|ZP_00708090.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|188494594, gi... - gi\|75515413\|ref\|ZP_00737570.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|187427832, gi... - gi\|75179455\|ref\|ZP_00699459.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Sh... gi\|168751476, gi... - gi\|188014503\|gb\|EDU52625.1\| HflK protein [Escherichia coli O157:H7 str. EC4113], gi\|168751476\|ref\|ZP... gi\|157077181, gi... - gi\|75188885\|ref\|ZP_00702152.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|168760414, gi... - gi\|189368981\|gb\|EDU87397.1\| HflK protein [Escherichia coli O157:H7 str. EC4501], gi\|168760414\|ref\|ZP... gi\|168754743, gi... - gi\|189357782\|gb\|EDU76201.1\| HflK protein [Escherichia coli O157:H7 str. EC4401], gi\|168754743\|ref\|ZP... gi\|74314659, gi\|... - gi\|74314659\|ref\|YP_313078.1\| FtsH protease regulator HflK [Shigella sonnei Ss046], gi\|73858136\|gb\|AA... gi\|168774115, gi... - gi\|187770328\|gb\|EDU34172.1\| HflK protein [Escherichia coli O157:H7 str. EC4196], gi\|168774115\|ref\|ZP... gi\|85676925, gi\|... - gi\|89110894\|ref\|AP_004674.1\| modulator for HflB protease specific for phage lambda cII repressor [Es... gi\|189363990, gi... - gi\|189363990\|gb\|EDU82409.1\| HflK protein [Escherichia coli O157:H7 str. EC4486], gi\|168766451\|ref\|ZP...	2.0E-85	[1..419]	[1..419]
gi\|191165677, gi... - gi\|75231233\|ref\|ZP_00717640.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|75212277, gi\|... - gi\|75212277\|ref\|ZP_00712317.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|193066027, gi... - gi\|75255901\|ref\|ZP_00727633.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|192955827, gi... - gi\|75234277\|ref\|ZP_00718665.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|218697923, gi... - gi\|218697923\|ref\|YP_002405590.1\| FtsH protease regulator HflK [Escherichia coli 55989], gi\|218354655...	2.0E-85	[1..419]	[1..419]
gi\|24115529, gi\|... - gi\|24115529\|ref\|NP_710039.1\| FtsH protease regulator HflK [Shigella flexneri 2a str. 301], gi\|240548... gi\|30043810, gi\|... - gi\|30065546\|ref\|NP_839717.1\| FtsH protease regulator HflK [Shigella flexneri 2a str. 2457T], gi\|3004...	2.0E-85	[1..419]	[1..419]
gi\|81247996, gi\|... - gi\|82546585\|ref\|YP_410532.1\| FtsH protease regulator HflK [Shigella boydii Sb227], gi\|81247996\|gb\|AB...	2.0E-85	[1..419]	[1..419]
gi\|88858906, gi\|... - gi\|88858906\|ref\|ZP_01133547.1\| HflK complex with HflC [Pseudoalteromonas tunicata D2], gi\|88819132\|g...	4.0E-85	[1..367]	[3..351]
gi\|54310428, gi\|... - gi\|54310428\|ref\|YP_131448.1\| putative membrane protease subunits [Photobacterium profundum SS9], gi\|...	9.0E-85	[1..403]	[1..386]

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Predicted Domain #1

Region A:
Residues: [1-121]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWNQPGNNG QDRDPWGSSK PGSNSGGNGN KGGRDQGPPD LDDIFRKLSK KLGGFGGGKG  60
   61 TGSGGGSSSQ GPRPQLGGRI VAIAAAAVVI IWAASGFYTI KEAERGVVTR FGKFSHLVEP 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [122-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNWKPTFIDD VTPVNVEAVR ELAASGVMLT SDENVVRVEM NVQYRVTDPQ KYLFSVTSPD  60
   61 DSLRQATDSA LRGVIGKYTM DRILTEGRTV IRSDTQRELE ETIKPYNMGI TLLDVNFQAA 120
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.39
Match:	1winA
Description:	Solution Structure of the Band 7 Domain of the mouse Flotillin 2 Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.45278097493666	bayes_pls_golite062009
protein binding	0.741098311996669	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [243-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPEEMKAAFD DAIAARENEQ QYIREAEAYT NEVQPRANGQ AQRILEEARA YKTQTILEAQ  60
   61 GEVARFAKIL PEYKAAPQIT RERLYIETME KVLSHTRKVL VNDKSGNLMV LPLDQMLKGG 120
  121 NAPAAKSDNS ASNLLRLPPS TKSNASGASN TSSSNQGDIM DQRRANAQRN DYQRQGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.39794
Match:	2i1jA
Description:	No description for 2i1jA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: