YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16762972
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. CT18
Length:	500 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16762972.

Description	E-value	Query Range	Subject Range
gi\|237703699, gi... - gi\|237703699\|ref\|ZP_04534180.1\| proline/glycine betaine transporter [Escherichia sp. 3_2_53FAA], gi\|... gi\|91075232, gi\|... - gi\|91213658\|ref\|YP_543644.1\| proline/glycine betaine transporter [Escherichia coli UTI89], gi\|910752... gi\|26250926, gi\|... - gi\|26250926\|ref\|NP_756966.1\| proline/glycine betaine transporter [Escherichia coli CFT073], gi\|26111...	3.0E-60	[1..500]	[12..511]
gi\|218367969, gi... - gi\|218561200\|ref\|YP_002394113.1\| proline/glycine betaine transporter [Escherichia coli S88], gi\|2183... gi\|218429971, gi... - gi\|218692407\|ref\|YP_002400619.1\| proline/glycine betaine transporter [Escherichia coli ED1a], gi\|218... gi\|115515522, gi... - gi\|117626398\|ref\|YP_859721.1\| proline/glycine betaine transporter [Escherichia coli APEC O1], gi\|115... gi\|227886851, gi... - gi\|227886851\|ref\|ZP_04004656.1\| proline/glycine betaine transporter [Escherichia coli 83972], gi\|227...	4.0E-60	[1..500]	[1..500]
gi\|1661219 - gi\|1661219\|gb\|AAC44538.1\| ProP [Escherichia coli]	7.0E-60	[1..500]	[1..500]
gi\|110644469, gi... - gi\|110644469\|ref\|YP_672199.1\| proline/glycine betaine transporter [Escherichia coli 536], gi\|1103460... PROP_ECO57 - Proline/betaine transporter OS=Escherichia coli O157:H7 GN=proP PE=3 SV=1 EG11612 - proline /glycine betaine transporter / Proline /betaine permease, minor; osmosensor /osmoregulator gi\|15804703, gi\|... - gi\|15804703\|ref\|NP_290744.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 EDL933], ... gi\|13364570, gi\|... - gi\|15834347\|ref\|NP_313120.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 str. Saka... PROP_ECOLI - Proline/betaine transporter (Proline porter II) (PPII) - Escherichia coli gi\|168755291, gi... - gi\|189357490\|gb\|EDU75909.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4401], gi\|1... gi\|188017559, gi... - gi\|188017559\|gb\|EDU55681.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4113], gi\|1... gi\|124501194, gi... - gi\|124527751\|ref\|ZP_01699186.1\| metabolite/H+ symporter, major facilitator superfamily (MFS) [Escher... gi\|238863280, gi... - gi\|238903219\|ref\|YP_002929015.1\| proline/glycine betaine transporter [Escherichia coli BW2952], gi\|2... gi\|194437276, gi... - gi\|83587236\|ref\|ZP_00925865.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|251787365, gi... - gi\|251787365\|ref\|YP_003001669.1\| hypothetical protein B21_03943 [Escherichia coli BL21], gi\|24237963... gi\|191173340, gi... - gi\|75239082\|ref\|ZP_00723062.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|253775260, gi... - gi\|254290795\|ref\|YP_003056543.1\| proline/glycine betaine transporter [Escherichia coli BL21(DE3)], g... gi\|188494432, gi... - gi\|75514870\|ref\|ZP_00737099.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|254164045, gi... - gi\|254164045\|ref\|YP_003047153.1\| proline/glycine betaine transporter [Escherichia coli B str. REL606... gi\|82779157, gi\|... - gi\|82779157\|ref\|YP_405506.1\| proline/glycine betaine transporter [Shigella dysenteriae Sd197], gi\|81... gi\|254796133, gi... - gi\|254796133\|ref\|YP_003080970.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 str. ... gi\|89110832, gi\|... - gi\|89110832\|ref\|AP_004612.1\| proline/glycine betaine transporter [Escherichia coli str. K-12 substr.... EG11612 - proline /glycine betaine transporter / Proline /betaine permease, minor; osmosensor /osmoregulator gi\|208807066, gi... - gi\|208807066\|ref\|ZP_03249403.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4206], ... gi\|195935900 - gi\|195935900\|ref\|ZP_03081282.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 str. E... gi\|208818646, gi... - gi\|208818646\|ref\|ZP_03258966.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4042], ... gi\|208733226, gi... - gi\|208811949\|ref\|ZP_03253278.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4045], ... gi\|217324260, gi... - gi\|217324260\|ref\|ZP_03440344.1\| proline/betaine transporter [Escherichia coli O157:H7 str. TW14588],... gi\|209400808, gi... - gi\|209400808\|ref\|YP_002273655.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4115],... gi\|218434823, gi... - gi\|218707726\|ref\|YP_002415245.1\| proline/glycine betaine transporter [Escherichia coli UMN026], gi\|2... gi\|218372761, gi... - gi\|218702775\|ref\|YP_002410404.1\| proline/glycine betaine transporter [Escherichia coli IAI39], gi\|21... gi\|168766380, gi... - gi\|189364250\|gb\|EDU82669.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4486], gi\|1... gi\|168760970, gi... - gi\|189368614\|gb\|EDU87030.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4501], gi\|1... gi\|168780533, gi... - gi\|189001735\|gb\|EDU70721.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4076], gi\|1... gi\|187769958, gi... - gi\|187769958\|gb\|EDU33802.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4196], gi\|1... gi\|189379187, gi... - gi\|189379187\|gb\|EDU97603.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC508], gi\|16... gi\|168784738, gi... - gi\|189374791\|gb\|EDU93207.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC869], gi\|16... gi\|170083563, gi... - gi\|170083563\|ref\|YP_001732883.1\| proline/glycine betaine transporter [Escherichia coli str. K-12 sub... gi\|169756819, gi... - gi\|170021891\|ref\|YP_001726845.1\| proline/glycine betaine transporter [Escherichia coli ATCC 8739], g...	2.0E-59	[1..500]	[1..500]
gi\|74314596, gi\|... - gi\|74314596\|ref\|YP_313015.1\| proline/glycine betaine transporter [Shigella sonnei Ss046], gi\|7385807...	2.0E-59	[1..500]	[1..500]
gi\|75212040, gi\|... - gi\|75212040\|ref\|ZP_00712095.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|75197963, gi\|... - gi\|75197963\|ref\|ZP_00708033.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157079181, gi... - gi\|75188827\|ref\|ZP_00702094.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|209921600, gi... - gi\|209921600\|ref\|YP_002295684.1\| proline/glycine betaine transporter [Escherichia coli SE11], gi\|209... gi\|218363432, gi... - gi\|218556663\|ref\|YP_002389577.1\| proline/glycine betaine transporter [Escherichia coli IAI1], gi\|218... gi\|218697813, gi... - gi\|218697813\|ref\|YP_002405480.1\| proline/glycine betaine transporter [Escherichia coli 55989], gi\|21... gi\|193063071, gi... - gi\|75259030\|ref\|ZP_00730398.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|193067855, gi... - gi\|75238640\|ref\|ZP_00722629.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|190904287, gi... - gi\|75231294\|ref\|ZP_00717701.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ...	2.0E-59	[1..500]	[1..500]
gi\|224586055, gi... - gi\|224586055\|ref\|YP_002639854.1\| ProP protein [Salmonella enterica subsp. enterica serovar Paratyphi... gi\|238912746 - gi\|238912746\|ref\|ZP_04656583.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ente... gi\|62182739, gi\|... - gi\|62182739\|ref\|YP_219156.1\| proline/glycine betaine transporter [Salmonella enterica subsp. enteric...	4.0E-59	[1..500]	[1..500]
gi\|194468743, gi... - gi\|194468743\|ref\|ZP_03074727.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|197212561, gi... - gi\|197248858\|ref\|YP_002149205.1\| proline/betaine transporter [Salmonella enterica subsp. enterica se... gi\|197264002, gi... - gi\|197264002\|ref\|ZP_03164076.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|199605388, gi... - gi\|200388290\|ref\|ZP_03214902.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|195630582, gi... - gi\|195630582\|gb\|EDX49194.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|205342159, gi... - gi\|205342159\|gb\|EDZ28923.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|194403930, gi... - gi\|194445267\|ref\|YP_002043540.1\| proline/betaine transporter [Salmonella enterica subsp. enterica se... gi\|194406872, gi... - gi\|194448568\|ref\|YP_002048281.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... gi\|205330200, gi... - gi\|205330200\|gb\|EDZ16964.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|168231304, gi... - gi\|205334337\|gb\|EDZ21101.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|168243707, gi... - gi\|205337320\|gb\|EDZ24084.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|168263371, gi... - gi\|205347989\|gb\|EDZ34620.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|161617432, gi... - gi\|161617432\|ref\|YP_001591397.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... gi\|205323027, gi... - gi\|205323027\|gb\|EDZ10866.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... PROP_SALTY - Proline/betaine transporter OS=Salmonella typhimurium GN=proP PE=3 SV=2 PROP_SALTY - Proline/betaine transporter OS=Salmonella typhimurium GN=proP PE=3 SV=2 gi\|204927333, gi... - gi\|204927333\|ref\|ZP_03218535.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|205355061, gi... - gi\|205355061\|ref\|YP_002228862.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... PROP_SALTY - Proline/betaine transporter OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=proP ... gi\|206711247, gi... - gi\|207859444\|ref\|YP_002246095.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... lcl\|NC_016856.1_... - [gene=proP] [protein=proline/glycine betaine transporter] [protein_id=YP_005240596.1] [location=4544...	5.0E-59	[1..500]	[1..500]
gi\|82546446, gi\|... - gi\|82546446\|ref\|YP_410393.1\| proline/glycine betaine transporter [Shigella boydii Sb227], gi\|8124785...	5.0E-59	[1..500]	[1..500]
gi\|110807890, gi... - gi\|110807890\|ref\|YP_691410.1\| proline/glycine betaine transporter [Shigella flexneri 5 str. 8401], g... gi\|56384064, gi\|... - gi\|56480513\|ref\|NP_709830.2\| proline/glycine betaine transporter [Shigella flexneri 2a str. 301], gi... gi\|30042939, gi\|... - gi\|30064680\|ref\|NP_838851.1\| proline/glycine betaine transporter [Shigella flexneri 2a str. 2457T], ...	7.0E-59	[1..500]	[1..500]

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Predicted Domain #1

Region A:
Residues: [1-500]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRKKIKPI TLGDVTIIDD GKLRKAITAA SLGNAMEWFD FGVYGFVAYA LGKVFFPGAD  60
   61 PSVQMIAALA TFSVPFLIRP LGGLFFGMLG DKYGRQKILA ITIVIMSIST FCIGLIPSYA 120
  121 TIGIWAPILL LLCKMAQGFS VGGEYTGASI FVAEYSPDRK RGFMGSWLDF GSIAGFVLGA 180
  181 GVVVLISTIV GEENFLEWGW RIPFFIALPL GIIGLYLRHA LEETPAFQQH VDKLEQGDRE 240
  241 GLQDGPKVSF KEIATKHWRS LLSCIGLVIA TNVTYYMLLT YMPSYLSHNL HYSEDHGVLI 300
  301 IIAIMIGMLF VQPVMGLLSD RFGRRPFVIM GSIALFALAI PAFILINSNV IGLIFAGLLM 360
  361 LAVILNCFTG VMASTLPAMF PTHIRYSALA AAFNISVLIA GLTPTLAAWL VESSQDLMIP 420
  421 AYYLMVIAVI GLITGISMKE TANRPLKGAT PAASDIQEAK EILGEHYDNI EQKIDDIDQE 480
  481 IAELQVKRSR LVQQHPRIDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
binding	0.805286077372817	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: