YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7427735, gi\|2...
Organism:	Escherichia coli
Length:	459 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7427735, gi|2....

Description	E-value	Query Range	Subject Range
gi\|26111062, gi\|... - gi\|26250631\|ref\|NP_756671.1\| coproporphyrinogen III oxidase [Escherichia coli CFT073], gi\|26111062\|g...	456.0	[0..1]	[459..1]
gi\|226902834, gi... - gi\|237702897\|ref\|ZP_04533378.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia sp. 3... gi\|115515264, gi... - gi\|117626140\|ref\|YP_859463.1\| coproporphyrinogen III oxidase [Escherichia coli APEC O1], gi\|11551526... gi\|91074987, gi\|... - gi\|91213413\|ref\|YP_543399.1\| coproporphyrinogen III oxidase [Escherichia coli UTI89], gi\|91074987\|gb...	456.0	[0..1]	[459..1]
gi\|15804452, gi\|... - gi\|15804452\|ref\|NP_290492.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 EDL933], gi\|12... gi\|25284558 - pir\|\|D86074 O2-independent coproporphyrinogen III oxidase [imported] - Escherichia coli (strain O157...	455.0	[0..1]	[459..1]
gi\|82778959, gi\|... - gi\|82778959\|ref\|YP_405308.1\| O2-independent coproporphyrinogen III oxidase [Shigella dysenteriae Sd1...	454.0	[0..1]	[459..1]
gi\|304972 - gi\|304972\|gb\|AAB03001.1\| ORF_o459 [Escherichia coli] gi\|304972\|gb\|AAB... - ORF_o459 [Escherichia coli]	452.0	[0..1]	[459..1]
gi\|238902934, gi... - gi\|238902934\|ref\|YP_002928730.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-i... gi\|251787131, gi... - gi\|251787131\|ref\|YP_003001435.1\| hypothetical protein B21_03701 [Escherichia coli BL21], gi\|24237940... gi\|161984816 - gi\|161984816\|ref\|YP_410158.2\| coproporphyrinogen III oxidase [Shigella boydii Sb227] gi\|254290568, gi... - gi\|254290568\|ref\|YP_003056316.1\| coproporphyrinogen III oxidase [Escherichia coli BL21(DE3)], gi\|253... gi\|161986407 - gi\|161986407\|ref\|YP_312791.2\| coproporphyrinogen III oxidase [Shigella sonnei Ss046] gi\|254163818, gi... - gi\|254163818\|ref\|YP_003046926.1\| coproporphyrinogen III oxidase [Escherichia coli B str. REL606], gi... gi\|168748853, gi... - gi\|188016759\|gb\|EDU54881.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|254595258, gi... - gi\|254795858\|ref\|YP_003080695.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-i... gi\|168755535, gi... - gi\|189357108\|gb\|EDU75527.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|168761767, gi... - gi\|189367897\|gb\|EDU86313.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|208728252, gi... - gi\|208808451\|ref\|ZP_03250788.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|208734247, gi... - gi\|208812970\|ref\|ZP_03254299.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|208741095, gi... - gi\|208820972\|ref\|ZP_03261292.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|209157787, gi... - gi\|209396387\|ref\|YP_002273383.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli... gi\|217322657, gi... - gi\|217326436\|ref\|ZP_03442520.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|218556426, gi... - gi\|218556426\|ref\|YP_002389340.1\| coproporphyrinogen III oxidase [Escherichia coli IAI1], gi\|21836319... gi\|218697580, gi... - gi\|218697580\|ref\|YP_002405247.1\| coproporphyrinogen III oxidase [Escherichia coli 55989], gi\|2183543... gi\|168768152, gi... - gi\|189362689\|gb\|EDU81108.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|168775317, gi... - gi\|187769143\|gb\|EDU32987.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|189001408, gi... - gi\|189001408\|gb\|EDU70394.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|189373340, gi... - gi\|189373340\|gb\|EDU91756.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|168799571, gi... - gi\|189378080\|gb\|EDU96496.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|169757047, gi... - gi\|170022119\|ref\|YP_001727073.1\| coproporphyrinogen III oxidase [Escherichia coli ATCC 8739], gi\|169... gi\|169891174, gi... - gi\|170083339\|ref\|YP_001732659.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-i... gi\|195937504 - gi\|195937504\|ref\|ZP_03082886.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 str. EC4024... gi\|124501232, gi... - gi\|124527530\|ref\|ZP_01698995.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... EG11836 - coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent / Coproporphyrinogen I... gi\|89110161, gi\|... - gi\|89110161\|ref\|AP_003941.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-indep... gi\|192929369, gi... - gi\|75258151\|ref\|ZP_00729612.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|193068087, gi... - gi\|75238309\|ref\|ZP_00722308.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... EG11836 - coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent / Coproporphyrinogen I... gi\|188494005, gi... - gi\|75513984\|ref\|ZP_00736337.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|38704208 - gi\|38704208\|ref\|NP_312816.2\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 str. Sakai] gi\|75197742, gi\|... - gi\|75197742\|ref\|ZP_00707812.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|157081165, gi... - gi\|75188601\|ref\|ZP_00701868.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|75230387, gi\|... - gi\|75230387\|ref\|ZP_00716873.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|194428658, gi... - gi\|75210116\|ref\|ZP_00710295.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|38704208 - gi\|38704208\|ref\|NP_312816.2\| coproporphyrinogen III oxidase [Escherichia coli O157:H7] gi\|194435183, gi... - gi\|83568941\|ref\|ZP_00920407.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... HEMN_ECOLI - Oxygen-independent coproporphyrinogen III oxidase (EC 1.3.99.22) (Coproporphyrinogenase) (Coprogen o... gi\|187730229, gi... - gi\|75176748\|ref\|ZP_00696876.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|194422729, gi... - gi\|83586284\|ref\|ZP_00924920.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta...	451.0	[0..3]	[459..1]
gi\|75237832, gi\|... - gi\|75237832\|ref\|ZP_00721847.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|110644206, gi... - gi\|110644206\|ref\|YP_671936.1\| coproporphyrinogen III oxidase [Escherichia coli 536], gi\|110345798\|gb...	450.0	[0..3]	[459..1]
gi\|30043104, gi\|... - gi\|30064844\|ref\|NP_839015.1\| coproporphyrinogen III oxidase [Shigella flexneri 2a str. 2457T], gi\|30... gi\|110807449, gi... - gi\|110807449\|ref\|YP_690969.1\| coproporphyrinogen III oxidase [Shigella flexneri 5 str. 8401], gi\|110... gi\|56384011, gi\|... - gi\|56480460\|ref\|NP_709665.2\| coproporphyrinogen III oxidase [Shigella flexneri 2a str. 301], gi\|5638...	448.0	[0..3]	[459..1]

Back

Predicted Domain #1

Region A:
Residues: [1-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMSVQQIDW DLALIQKYNY SGPRYTSYPT ALEFSEDFGE QAFLQAVARY PERPLSLYVH  60
   61 IPFCHKLCYF CGCNKIVTRQ QHKADQYLDA LEQEIVHRAP LFAGRHVSQL HWGGGTPTYL 120
  121 NKAQISRLMK LLRENFQFNA DAEISIEVDP REIELDVLDH LRAEGFNRLS MGVQDFNKEV 180
  181 QRLVNREQDE EFIFALLNHA REIGFTSTNI DLIYGLPKQT PESFAFTLKR VAELNPDRLS 240
  241 VFNYAHLPTI FAAQRKIKDA DLPSPQQKLD ILQETIAFLT QSGYQFIGMD HFARPDDELA 300
  301 VAQREGVLHR NFQGYTTQGD TDLLGMGVSA ISMIGDCYAQ NQKELKQYYQ QVDEQGNALW 360
  361 RGIALTRDDC IRRDVIKSLI CNFRLDYAPI EKQWDLHFAD YFAEDLKLLA PLAKDGLVDV 420
  421 DEKGIQVTAK GRLLIRNICM CFDTYLRQKA RMQQFSRVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	127.0
Match:	1oltA
Description:	Coproporphyrinogen III oxidase (HemN) from Escherichia coli is a Radical SAM enzyme.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
coproporphyrinogen oxidase activity	2.62711845981655	bayes_pls_golite062009
biotin synthase activity	2.22585029668171	bayes_pls_golite062009
radical SAM enzyme activity	2.08127882819276	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1.93818807823452	bayes_pls_golite062009
catalytic activity	1.85375915825216	bayes_pls_golite062009
sulfurtransferase activity	1.26112752511053	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	0.35292941647096	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: