YRC Public Data Repository - Protein Structure Prediction

Protein:	ASSY_ECOLI
Organism:	Escherichia coli
Length:	447 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASSY_ECOLI.

Description	E-value	Query Range	Subject Range
ASSY_METFK - Argininosuccinate synthase OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=arg...	410.0	[0..8]	[422..1]
ASSY_ALCBS - Argininosuccinate synthase OS=Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 ...	409.0	[0..8]	[423..1]
ASSY_SACD2 - Argininosuccinate synthase OS=Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) GN=arg...	408.0	[0..5]	[422..1]
ASSY_METCA - Argininosuccinate synthase OS=Methylococcus capsulatus GN=argG PE=3 SV=1 ASSY_METCA - Argininosuccinate synthase OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=a...	407.0	[0..12]	[418..7]
gi\|88801179, gi\|... - gi\|88801179\|ref\|ZP_01116722.1\| argininosuccinate synthase [Reinekea sp. MED297], gi\|88776082\|gb\|EAR0...	407.0	[0..8]	[418..1]
ASSY_THICR - Argininosuccinate synthase OS=Thiomicrospira crunogena (strain XCL-2) GN=argG PE=3 SV=1	406.0	[0..8]	[420..1]
ASSY_PSYWF - Argininosuccinate synthase OS=Psychrobacter sp. (strain PRwf-1) GN=argG PE=3 SV=1	406.0	[0..13]	[423..11]
ASSY_NITMU - Argininosuccinate synthase OS=Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) GN=argG PE=...	406.0	[0..12]	[422..7]
gi\|25293778 - gi\|25293778\|pir\|\|D97679 argininosuccinate synthase (PA3525) [imported] - Agrobacterium tumefaciens (... gi\|15889923, gi\|... - gi\|15889923\|ref\|NP_355604.1\| argininosuccinate synthase [Agrobacterium tumefaciens str. C58], gi\|151...	406.0	[0..1]	[422..50]
ASSY_CARHZ - Argininosuccinate synthase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-...	406.0	[0..10]	[424..1]

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Predicted Domain #1

Region A:
Residues: [1-447]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTILKHLPV GQRIGIAFSG GLDTSAALLW MRQKGAVPYA YTANLGQPDE EDYDAIPRRA  60
   61 MEYGAENARL IDCRKQLVAE GIAAIQCGAF HNTTGGLTYF NTTPLGRAVT GTMLVAAMKE 120
  121 DGVNIWGDGS TYKGNDIERF YRYGLLTNAE LQIYKPWLDT DFIDELGGRH EMSEFMIACG 180
  181 FDYKMSVEKA YSTDSNMLGA THEAKDLEYL NSSVKIVNPI MGVKFWDESV KIPAEEVTVR 240
  241 FEQGHPVALN GKTFSDDVEM MLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
  301 HIAYERLLTG IHNEDTIEQY HAHGRQLGRL LYQGRWFDSQ ALMLRDSLQR WVASQITGEV 360
  361 TLELRRGNDY SILNTVSENL TYKPERLTME KGDSVFSPDD RIGQLTMRNL DITDTREKLF 420
  421 GYAKTGLLSS SAASGVPQVE NLENKGQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	104.0
Match:	1k92A
Description:	Argininosuccinate synthetase, N-terminal domain; Argininosuccinate synthetase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
argininosuccinate synthase activity	5.55984418125277	bayes_pls_golite062009
ligase activity	2.54636182867584	bayes_pls_golite062009
catalytic activity	1.4716728594386	bayes_pls_golite062009
binding	0.949267645607863	bayes_pls_golite062009
protein binding	0.476576076629648	bayes_pls_golite062009
asparagine synthase (glutamine-hydrolyzing) activity	0.3673193848392	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.204705463374024	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: