YRC Public Data Repository - Protein Structure Prediction

Protein:	FADH_ECOLI
Organism:	Escherichia coli
Length:	672 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FADH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|15803622, gi\|... - gi\|15803622\|ref\|NP_289655.1\| putative NADPH dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|1251... gi\|168773258, gi... - gi\|187771008\|gb\|EDU34852.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|13363436, gi\|... - gi\|15833217\|ref\|NP_311990.1\| putative NADPH dehydrogenase [Escherichia coli O157:H7], gi\|13363436\|db... gi\|189001019, gi... - gi\|189001019\|gb\|EDU70005.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4076], gi\|168... gi\|168785959, gi... - gi\|189374009\|gb\|EDU92425.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|254795032, gi... - gi\|254795032\|ref\|YP_003079869.1\| 2,4-dienoyl-CoA reductase, NADH and FMN-linked [Escherichia coli O1... gi\|189379825, gi... - gi\|189379825\|gb\|EDU98241.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC508], gi\|1687... gi\|168749327, gi... - gi\|188016361\|gb\|EDU54483.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|168754056, gi... - gi\|189358614\|gb\|EDU77033.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|189367591, gi... - gi\|189367591\|gb\|EDU86007.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|168769493, gi... - gi\|189361417\|gb\|EDU79836.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|209160599, gi... - gi\|209399199\|ref\|YP_002272554.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4115], g... gi\|13363436, gi\|... - gi\|15833217\|ref\|NP_311990.1\| putative NADPH dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|195937227 - gi\|195937227\|ref\|ZP_03082609.1\| putative NADPH dehydrogenase [Escherichia coli O157:H7 str. EC4024] gi\|208726913, gi... - gi\|208807112\|ref\|ZP_03249449.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4206], gi... gi\|25320364, gi\|... - pir\|\|B85969 probable NADPH dehydrogenase ygjL [imported] - Escherichia coli (strain O157:H7, substra... gi\|208812646, gi... - gi\|208812646\|ref\|ZP_03253975.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4045], gi... gi\|208821831, gi... - gi\|208821831\|ref\|ZP_03262151.1\| 2,4-dienoyl-CoA reductase [Escherichia coli O157:H7 str. EC4042], gi...	557.0	[0..1]	[672..1]
gi\|26110098, gi\|... - gi\|26249670\|ref\|NP_755710.1\| 2,4-dienoyl-CoA reductase [Escherichia coli CFT073], gi\|26110098\|gb\|AAN... gi\|227887806, gi... - gi\|227887806\|ref\|ZP_04005611.1\| 2,4-dienoyl-CoA reductase [Escherichia coli 83972], gi\|227835202\|gb\|...	555.0	[0..1]	[672..1]
gi\|75197034, gi\|... - gi\|75197034\|ref\|ZP_00707104.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Esche...	554.0	[0..1]	[672..1]
gi\|83584804, gi\|... - gi\|83584804\|ref\|ZP_00923465.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Esche...	554.0	[0..1]	[672..1]
gi\|75513295, gi\|... - gi\|75513295\|ref\|ZP_00735719.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Esche...	554.0	[0..1]	[672..1]
gi\|82545337, gi\|... - gi\|82545337\|ref\|YP_409284.1\| putative NADPH dehydrogenase [Shigella boydii Sb227], gi\|81246748\|gb\|AB...	553.0	[0..1]	[672..1]
gi\|187428224, gi... - gi\|75176057\|ref\|ZP_00696225.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Shige...	553.0	[0..1]	[672..1]
gi\|75239349, gi\|... - gi\|75239349\|ref\|ZP_00723320.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Esche... gi\|74313525, gi\|... - gi\|74313525\|ref\|YP_311944.1\| putative NADPH dehydrogenase [Shigella sonnei Ss046], gi\|73857002\|gb\|AA...	553.0	[0..1]	[672..1]
gi\|75211034, gi\|... - gi\|75211034\|ref\|ZP_00711147.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Esche...	553.0	[0..1]	[672..1]
gi\|110616511, gi... - gi\|110806963\|ref\|YP_690483.1\| putative NADPH dehydrogenase [Shigella flexneri 5 str. 8401], gi\|11061...	552.0	[0..1]	[672..1]

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Predicted Domain #1

Region A:
Residues: [1-672]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYPSLFAPL DLGFTTLKNR VLMGSMHTGL EEYPDGAERL AAFYAERARH GVALIVSGGI  60
   61 APDLTGVGME GGAMLNDASQ IPHHRTITEA VHQEGGKIAL QILHTGRYSY QPHLVAPSAL 120
  121 QAPINRFVPH ELSHEEILQL IDNFARCAQL AREAGYDGVE VMGSEGYLIN EFLTLRTNQR 180
  181 SDQWGGDYRN RMRFAVEVVR AVRERVGNDF IIIYRLSMLD LVEDGGTFAE TVELAQAIEA 240
  241 AGATIINTGI GWHEARIPTI ATPVPRGAFS WVTRKLKGHV SLPLVTTNRI NDPQVADDIL 300
  301 SRGDADMVSM ARPFLADAEL LSKAQSGRAD EINTCIGCNQ ACLDQIFVGK VTSCLVNPRA 360
  361 CHETKMPILP AVQKKNLAVV GAGPAGLAFA INAAARGHQV TLFDAHSEIG GQFNIAKQIP 420
  421 GKEEFYETLR YYRRMIEVTG VTLKLNHTVT ADQLQAFDET ILASGIVPRT PPIDGIDHPK 480
  481 VLSYLDVLRD KAPVGNKVAI IGCGGIGFDT AMYLSQPGES TSQNIAGFCN EWGIDSSLQQ 540
  541 AGGLSPQGMQ IPRSPRQIVM LQRKASKPGQ GLGKTTGWIH RTTLLSRGVK MIPGVSYQKI 600
  601 DDDGLHVVIN GETQVLAVDN VVICAGQEPN RALAQPLIDS GKTVHLIGGC DVAMELDARR 660
  661 AIAQGTRLAL EI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	157.0
Match:	1ps9A
Description:	The Crystal Structure and Reaction Mechanism of E. coli 2,4-Dienoyl CoA Reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	1.31666452665754	bayes_pls_golite062009
catalytic activity	1.13824203225664	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.985549379433495	bayes_pls_golite062009
binding	0.868873167401965	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	0.242456601435627	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.202421999090553	bayes_pls_golite062009
2,4-dienoyl-CoA reductase (NADPH) activity	0.166737081461993	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: