YRC Public Data Repository - Protein Structure Prediction

Protein:	CYSI_ECOLI
Organism:	Escherichia coli
Length:	570 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYSI_ECOLI.

Description	E-value	Query Range	Subject Range
CYSI_SALCH - Sulfite reductase [NADPH] hemoprotein beta-component OS=Salmonella choleraesuis GN=cysI PE=3 SV=3 CYSI_SALCH - Sulfite reductase [NADPH] hemoprotein beta-component OS=Salmonella choleraesuis GN=cysI PE=3 SV=3 CYSI_SALCH - Sulfite reductase [NADPH] hemoprotein beta-component OS=Salmonella choleraesuis (strain SC-B67) GN=c...	493.0	[0..1]	[570..1]
CYSI_ALTMD - Sulfite reductase [NADPH] hemoprotein beta-component OS=Alteromonas mediterranea (strain DSM 17117 /... CYSI_ALTMD - Sulfite reductase [NADPH] hemoprotein beta-component OS=Alteromonas macleodii (strain DSM 17117 / De...	491.0	[0..1]	[570..1]
CYSI_ECOL6 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O6:H1 (strain CFT073 / ATCC... gi\|227888299, gi... - gi\|227888299\|ref\|ZP_04006104.1\| sulfite reductase subunit beta [Escherichia coli 83972], gi\|22783456... CYSI_ECOL6 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O6 GN=cysI PE=3 SV=3	489.0	[0..1]	[570..1]
gi\|145681 - gi\|145681\|gb\|AAA23651.1\| NADPH-sulfite reductase hemoprotein component	489.0	[0..1]	[570..3]
CYSI_KLEP7 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Klebsiella pneumoniae subsp. pneumoniae (str... gi\|110180264 - gi\|110180264\|gb\|ABG54373.1\| sulfite reductase subunit I [Klebsiella pneumoniae]	488.0	[0..1]	[570..1]
CYSI_ECOBB - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain B / BL21) GN=cysI P... CYSI_ECOBD - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain B / BL21-DE3) GN=cy... gi\|254037812, gi... - gi\|254037812\|ref\|ZP_04871870.1\| sulfite reductase hemoprotein [Escherichia sp. 1_1_43], gi\|226839436... CYSI_ECOBR - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain B / REL606) GN=cysI... gi\|118141 - gi\|118141\|sp\|P17846\|CYSI_ECOLI Sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP) (SIRHP) gi\|83585585, gi\|... - gi\|83585585\|ref\|ZP_00924228.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c...	488.0	[0..1]	[570..1]
gi\|75235636, gi\|... - gi\|75235636\|ref\|ZP_00719810.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c...	488.0	[0..1]	[570..1]
CYSI_ECOHS - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O9:H4 (strain HS) GN=cysI P...	488.0	[0..1]	[570..1]
gi\|192927322, gi... - gi\|75256970\|ref\|ZP_00728546.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... gi\|75230026, gi\|... - gi\|75230026\|ref\|ZP_00716536.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... gi\|194427921, gi... - gi\|75210973\|ref\|ZP_00711097.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... CYSI_ECO24 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O139:H28 (strain E24377A / ... gi\|13363089, gi\|... - gi\|15832872\|ref\|NP_311645.1\| sulfite reductase subunit beta [Escherichia coli O157:H7 str. Sakai], g... CYSI_SHIB3 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Shigella boydii serotype 18 (strain CDC 3083... CYSI_ECOLU - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O17:K52:H18 (strain UMN026 ... CYSI_ECO55 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain 55989 / EAEC) GN=cy... CYSI_ECO57 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O157:H7 GN=cysI PE=3 SV=3 gi\|209761638, gi... - pir\|\|C85926 sulfite reductase, alpha subunit [imported] - Escherichia coli (strain O157:H7, substrai... gi\|188494761, gi... - gi\|75512330\|ref\|ZP_00734882.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... gi\|254594104, gi... - gi\|254794704\|ref\|YP_003079541.1\| sulfite reductase, beta subunit, NAD(P)-binding, heme-binding [Esch... gi\|208806526, gi... - gi\|208806526\|ref\|ZP_03248863.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... gi\|12517224, gi\|... - gi\|15803281\|ref\|NP_289313.1\| sulfite reductase subunit beta [Escherichia coli O157:H7 EDL933], gi\|12... gi\|195939477 - gi\|195939477\|ref\|ZP_03084859.1\| sulfite reductase subunit beta [Escherichia coli O157:H7 str. EC4024... gi\|208821977, gi... - gi\|208821977\|ref\|ZP_03262297.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... gi\|208735118, gi... - gi\|208813841\|ref\|ZP_03255170.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... CYSI_ECOSE - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain SE11) GN=cysI PE=3 ... CYSI_ECO5E - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O157:H7 (strain EC4115 / EH... CYSI_ECO8A - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O8 (strain IAI1) GN=cysI PE... gi\|217319996, gi... - gi\|217327629\|ref\|ZP_03443712.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... gi\|189357298, gi... - gi\|189357298\|gb\|EDU75717.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|188015797, gi... - gi\|188015797\|gb\|EDU53919.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189362039, gi... - gi\|189362039\|gb\|EDU80458.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|168762834, gi... - gi\|189366860\|gb\|EDU85276.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189003610, gi... - gi\|189003610\|gb\|EDU72596.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|187769540, gi... - gi\|187769540\|gb\|EDU33384.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189377515, gi... - gi\|189377515\|gb\|EDU95931.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189372136, gi... - gi\|189372136\|gb\|EDU90552.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ...	488.0	[0..1]	[570..1]
CYSI_SHISS - Sulfite reductase [NADPH] hemoprotein beta-component OS=Shigella sonnei (strain Ss046) GN=cysI PE=3 ...	488.0	[0..1]	[570..1]

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Predicted Domain #1

Region A:
Residues: [1-65]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKHPGPLV VEGKLTDAER MKHESNYLRG TIAEDLNDGL TGGFKGDNFL LIRFHGMYQQ  60
   61 DDRDI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.49
Match:	1zj8A
Description:	Structure of Mycobacterium tuberculosis NirA protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	5.33578138806703	bayes_pls_golite062009
catalytic activity	0.732568437339568	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [66-570]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAERAEQKLE PRHAMLLRCR LPGGVITTKQ WQAIDKFAGE NTIYGSIRLT NRQTFQFHGI  60
   61 LKKNVKPVHQ MLHSVGLDAL ATANDMNRNV LCTSNPYESQ LHAEAYEWAK KISEHLLPRT 120
  121 RAYAEIWLDQ EKVATTDEEP ILGQTYLPRK FKTTVVIPPQ NDIDLHANDM NFVAIAENGK 180
  181 LVGFNLLVGG GLSIEHGNKK TYARTASEFG YLPLEHTLAV AEAVVTTQRD WGNRTDRKNA 240
  241 KTKYTLERVG VETFKAEVER RAGIKFEPIR PYEFTGRGDR IGWVKGIDDN WHLTLFIENG 300
  301 RILDYPARPL KTGLLEIAKI HKGDFRITAN QNLIIAGVPE SEKAKIEKIA KESGLMNAVT 360
  361 PQRENSMACV SFPTCPLAMA EAERFLPSFI DNIDNLMAKH GVSDEHIVMR VTGCPNGCGR 420
  421 AMLAEVGLVG KAPGRYNLHL GGNRIGTRIP RMYKENITEP EILASLDELI GRWAKEREAG 480
  481 EGFGDFTVRA GIIRPVLDPA RDLWD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	1aopA
Description:	SULFITE REDUCTASE STRUCTURE AT 1.6 ANGSTROM RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sulfite reductase (NADPH) activity	10.5477019483845	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	6.9484358652029	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	6.71341182064697	bayes_pls_golite062009
catalytic activity	1.39967796334655	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.747822858523869	bayes_pls_golite062009
oxidoreductase activity	0.272934629796331	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: