YRC Public Data Repository - Protein Structure Prediction

Protein:	MURE_ECOLI
Organism:	Escherichia coli
Length:	495 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MURE_ECOLI.

Description	E-value	Query Range	Subject Range
MURE_CALS4 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Caldanaerobacter subterrane... MURE_THETN - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Thermoanaerobacter tengcong...	449.0	[0..1]	[493..1]
gi\|20808076, gi\|... - gi\|20808076\|ref\|NP_623247.1\| UDP-N-acetylmuramyl tripeptide synthase [Thermoanaerobacter tengcongens... gi\|20808076 - gi\|20808076\|ref\|NP_623247.1\| UDP-N-acetylmuramyl tripeptide synthase [Thermoanaerobacter tengcongens...	448.0	[0..1]	[493..11]
gi\|166856057, gi... - gi\|76796234\|ref\|ZP_00778600.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Thermoanaerobacter ethanol... gi\|167040637, gi... - gi\|167040637\|ref\|YP_001663622.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Thermoanaerobacter sp. X... gi\|242257445, gi... - gi\|242257445\|ref\|ZP_04802310.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Thermoanaerobacter sp. X5...	442.0	[0..1]	[493..1]
gi\|78044715, gi\|... - gi\|78044715\|ref\|YP_360893.1\| UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase [Carb...	437.0	[0..1]	[492..1]
MURE1_CLOAB - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 1 OS=Clostridium acetobutylicu... MURE1_CLOAB, MUE... - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 1 OS=Clostridium acetobutylicu...	431.0	[0..1]	[494..1]
gi\|52307779, gi\|... - gi\|52425727\|ref\|YP_088864.1\| UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [Man...	430.0	[0..22]	[492..19]
gi\|42781669, gi\|... - gi\|42781669\|ref\|NP_978916.1\| UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase [Baci...	429.0	[0..1]	[491..1]
gi\|49329337, gi\|... - gi\|49477781\|ref\|YP_036697.1\| UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [Bac...	428.0	[0..1]	[491..1]
gi\|47568717, gi\|... - gi\|47568717\|ref\|ZP_00239413.1\| UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase [Ba...	427.0	[0..1]	[491..8]
MURE_PASMU - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Pasteurella multocida (stra... MURE_PASMU - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Pasteurella multocida GN=mu...	427.0	[0..9]	[492..6]

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Predicted Domain #1

Region A:
Residues: [1-495]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADRNLRDLL APWVPDAPSR ALREMTLDSR VAAAGDLFVA VVGHQADGRR YIPQAIAQGV  60
   61 AAIIAEAKDE ATDGEIREMH GVPVIYLSQL NERLSALAGR FYHEPSDNLR LVGVTGTNGK 120
  121 TTTTQLLAQW SQLLGEISAV MGTVGNGLLG KVIPTENTTG SAVDVQHELA GLVDQGATFC 180
  181 AMEVSSHGLV QHRVAALKFA ASVFTNLSRD HLDYHGDMEH YEAAKWLLYS EHHCGQAIIN 240
  241 ADDEVGRRWL AKLPDAVAVS MEDHINPNCH GRWLKATEVN YHDSGATIRF SSSWGDGEIE 300
  301 SHLMGAFNVS NLLLALATLL ALGYPLADLL KTAARLQPVC GRMEVFTAPG KPTVVVDYAH 360
  361 TPDALEKALQ AARLHCAGKL WCVFGCGGDR DKGKRPLMGA IAEEFADVAV VTDDNPRTEE 420
  421 PRAIINDILA GMLDAGHAKV MEGRAEAVTC AVMQAKENDV VLVAGKGHED YQIVGNQRLD 480
  481 YSDRVTVARL LGVIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	107.0
Match:	1e8cA
Description:	UDP-N-acetylmuramyl tripeptide synthetase MurE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.86493054281191	bayes_pls_golite062009
catalytic activity	3.03081854683329	bayes_pls_golite062009
UDP-N-acetylmuramate-L-alanine ligase activity	2.62956763198067	bayes_pls_golite062009
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity	2.38541436302257	bayes_pls_golite062009
ligase activity	2.2556848409907	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.19206014001612	bayes_pls_golite062009
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity	1.471039191151	bayes_pls_golite062009
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity	1.15437935952018	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: