YRC Public Data Repository - Protein Structure Prediction

Protein:	MTHR_ORYSJ
Organism:	Oryza sativa Japonica Group
Length:	594 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTHR_ORYSJ.

Description	E-value	Query Range	Subject Range
MTHR1_MAIZE - Methylenetetrahydrofolate reductase 1 OS=Zea mays PE=2 SV=1	853.0	[0..1]	[592..1]
MTHR1_ARATH - Methylenetetrahydrofolate reductase 1 OS=Arabidopsis thaliana GN=MTHFR1 PE=1 SV=1	847.0	[0..1]	[592..1]
gi\|67539426, gi\|... - gi\|67539426\|ref\|XP_663487.1\| hypothetical protein AN5883.2 [Aspergillus nidulans FGSC A4], ref\|XP_41... gi\|113911583 - gi\|113911583\|gb\|ABI48273.1\| methylenetetrahydrofolate reductase [Emericella nidulans]	840.0	[0..1]	[594..1]
gi\|71001564, gi\|... - gi\|71001564\|ref\|XP_755463.1\| methylenetetrahydrofolate reductase [Aspergillus fumigatus Af293], gi\|6...	835.0	[0..1]	[594..1]
gi\|169774983 - gi\|169774983\|ref\|XP_001821959.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83769822 - gi\|83769822\|dbj\|BAE59957.1\| unnamed protein product [Aspergillus oryzae] gi\|220694307, gi... - gi\|238496383\|ref\|XP_002379427.1\| methylenetetrahydrofolate reductase, putative [Aspergillus flavus N...	833.0	[0..1]	[594..1]
gi\|115384530, gi... - gi\|115384530\|ref\|XP_001208812.1\| methylenetetrahydrofolate reductase 2 [Aspergillus terreus NIH2624]...	832.0	[0..1]	[594..1]
gi\|119178804, gi... - gi\|90299825\|gb\|EAS29456.1\| hypothetical protein CIMG_08202 [Coccidioides immitis RS], gi\|119178804\|r...	832.0	[0..1]	[594..1]

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Predicted Domain #1

Region A:
Residues: [1-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVIEKIQEA AADGRTVFSF EYFPPKTEEG LDNLFERMDR MVAHGPNFCD ITWGAGGSTA  60
   61 DLTLEIANRM QNMVCVETMM HLTCTNMPVE KIDDALTTIK SNGIQNVLAL RGDPPHGQDK 120
  121 FVQVAGGFAC ALDLVQHIRA KYGDYFGITV AGYPEAHPDA IQSTEGATPE AYSNDLAYLK 180
  181 QKVDAGADLI ITQLFYDTDI FLKFVNDCRQ IGITCPIVPG IMPINNYKGF LRMTGFCKTK 240
  241 IPAEITAALE PIKDNEEAVK AYGIHLGTEM CKKILATGIK TLHLYTLNME KSALGILMNL 300
  301 GLIEESKISR SLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	100.0
Match:	1v93A
Description:	5,10-Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [314-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WRPPTNVFRV KEDVRPIFWA NRPKSYISRT LGWDQYPHGR WGDSRNPSYG ALTDYQFTRP  60
   61 RGRGKKLQEE WAVPVKSVED INERFMNFCQ GKLTSSPWSE LDGLQPETKI IDDQLVKINQ 120
  121 KGFLTINSQP AVNGERSDST SVGWGG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [460-594]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGGYVYQKAY LEFFCSKEKL DQLIEKSKAF PSLTYIAVNK DGESFSNIPT NAVNAVTWGV  60
   61 FPGKEIVQPT VVDSASFMVW KDEAFEIWSK GWACLFPEGD SSREILDKVQ KSYFLVSLVD 120
  121 NDYINGDLFA AFKEI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits