YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRH_STAAS
Organism:	Staphylococcus aureus subsp. aureus MSSA476
Length:	240 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRH_STAAS.

Description	E-value	Query Range	Subject Range
PYRH_STAS1 - Uridylate kinase OS=Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229...	228.0	[0..1]	[240..1]
gi\|23002919 - gi\|23002919\|ref\|ZP_00046591.1\| COG0528: Uridylate kinase [Lactobacillus gasseri] gi\|227094235, gi... - gi\|227521138\|ref\|ZP_03951187.1\| uridylate kinase [Lactobacillus gasseri JV-V03], gi\|227094235\|gb\|EEI... gi\|238834756, gi... - gi\|238852610\|ref\|ZP_04643020.1\| UMP kinase [Lactobacillus gasseri 202-4], gi\|238834756\|gb\|EEQ26983.1... PYRH_LACGA - Uridylate kinase OS=Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / ...	227.0	[0..1]	[238..1]
PYRH_ENTFA - Uridylate kinase OS=Enterococcus faecalis (strain ATCC 700802 / V583) GN=pyrH PE=1 SV=1 PYRH_ENTFA - Uridylate kinase OS=Enterococcus faecalis GN=pyrH PE=1 SV=1	227.0	[0..5]	[238..4]
PYRH_LACJO - Uridylate kinase OS=Lactobacillus johnsonii GN=pyrH PE=3 SV=1 PYRH_LACJO - Uridylate kinase OS=Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) GN=pyrH PE=3 SV=1 gi\|227890235, gi... - gi\|227890235\|ref\|ZP_04008040.1\| uridylate kinase [Lactobacillus johnsonii ATCC 33200], gi\|227849237\|...	227.0	[0..1]	[238..1]
gi\|220708047, gi... - gi\|221088054\|ref\|ZP_03557588.1\| uridylate kinase [Geobacillus sp. Y412MC61], gi\|220708047\|gb\|EED6342... PYRH_GEOKA - Uridylate kinase OS=Geobacillus kaustophilus (strain HTA426) GN=pyrH PE=3 SV=1 gi\|229329603, gi... - gi\|229499545\|ref\|ZP_04393229.1\| uridylate kinase [Geobacillus sp. Y412MC52], gi\|229329603\|gb\|EEN9515... PYRH_GEOKA - Uridylate kinase OS=Geobacillus kaustophilus GN=pyrH PE=3 SV=1	226.0	[0..3]	[238..2]
PYRH_STAHJ - Uridylate kinase OS=Staphylococcus haemolyticus (strain JCSC1435) GN=pyrH PE=3 SV=1	226.0	[0..1]	[240..1]
PYRH_STAEP - (Q8CSU1) Uridylate kinase (EC 2.7.4.-) (UK) (Uridine monophosphate kinase) (UMP kinase) PYRH_STAEQ - Uridylate kinase OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=pyrH PE=3 SV=1 gi\|242242541, gi... - gi\|242242541\|ref\|ZP_04796986.1\| uridylate kinase [Staphylococcus epidermidis W23144], gi\|242233968\|g... gi\|251805849, gi... - gi\|251810689\|ref\|ZP_04825162.1\| uridylate kinase [Staphylococcus epidermidis BCM-HMP0060], gi\|251805... PYRH_STAES - Uridylate kinase OS=Staphylococcus epidermidis (strain ATCC 12228) GN=pyrH PE=3 SV=1	225.0	[0..1]	[240..1]
PYRH_CARHZ - Uridylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN=p...	223.0	[0..3]	[238..2]
gi\|15292789, gi\|... - gi\|9293891\|dbj\|BAB01794.1\| unnamed protein product [Arabidopsis thaliana], gi\|20258857\|gb\|AAM14100.1...	222.0	[0..6]	[238..95]
PYRH_LACSS - Uridylate kinase OS=Lactobacillus sakei subsp. sakei (strain 23K) GN=pyrH PE=3 SV=1	221.0	[0..4]	[238..3]

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Predicted Domain #1

Region A:
Residues: [1-240]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQISKYKRV VLKLSGEALA GEKGFGINPV IIKSVAEQVA EVAKMDCEIA VIVGGGNIWR  60
   61 GKTGSDLGMD RGTADYMGML ATVMNALALQ DSLEQLDCDT RVLTSIEMKQ VAEPYIRRRA 120
  121 IRHLEKKRVV IFAAGIGNPY FSTDTTAALR AAEVEADVIL MGKNNVDGVY SADPKVNKDA 180
  181 VKYEHLTHIQ MLQEGLQVMD STASSFCMDN NIPLTVFSIM EEGNIKRAVM GEKIGTLITK 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.69897
Match:	1z9dA
Description:	Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
kinase activity	5.43826659128409	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	4.76215533422168	bayes_pls_golite062009
nucleotide kinase activity	4.36245911991838	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.17538459617947	bayes_pls_golite062009
uridylate kinase activity	3.54453921304057	bayes_pls_golite062009
catalytic activity	3.20382750184555	bayes_pls_golite062009
transferase activity	2.54481238004476	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.89315414622708	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	1.02979719559565	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: