YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|33239838, gi\|...
Organism:	Prochlorococcus marinus subsp. marinus str. CCMP1375
Length:	261 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|33239838, gi|....

Description	E-value	Query Range	Subject Range
gi\|27316645, gi\|... - gi\|27469096\|ref\|NP_765733.1\| uroporphyrin-III C-methyltransferase [Staphylococcus epidermidis ATCC 1...	218.0	[0..21]	[259..1]
gi\|57865554, gi\|... - gi\|57865554\|ref\|YP_189745.1\| uroporphyrin-III C-methyltransferase, putative [Staphylococcus epidermi...	216.0	[0..25]	[259..2]
gi\|196158491, gi... - gi\|88794338\|ref\|ZP_01110047.1\| uroporphyrin-III C-methyltransferase [Alteromonas macleodii 'Deep eco...	215.0	[0..5]	[259..216]
CYSG_ACIAD - Siroheme synthase OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=cysG PE=3 SV=1	214.0	[0..13]	[259..204]
gi\|77962694, gi\|... - gi\|77962694\|ref\|ZP_00826511.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia mollaretii ATCC 439...	213.0	[0..13]	[259..204]
CYSG_PSEU2 - Siroheme synthase OS=Pseudomonas syringae pv. syringae (strain B728a) GN=cysG PE=3 SV=1	213.0	[0..11]	[259..202]
SUMT_BACSU - Uroporphyrinogen-III C-methyltransferase OS=Bacillus subtilis (strain 168) GN=sumT PE=2 SV=1 SUMT_BACSU - Uroporphyrinogen-III C-methyltransferase OS=Bacillus subtilis GN=sumT PE=2 SV=1 gi\|221313761 - gi\|221313761\|ref\|ZP_03595566.1\| hypothetical protein BsubsN3_08562 [Bacillus subtilis subsp. subtili... gi\|221318685 - gi\|221318685\|ref\|ZP_03599979.1\| hypothetical protein BsubsJ_08496 [Bacillus subtilis subsp. subtilis... gi\|221322956 - gi\|221322956\|ref\|ZP_03604250.1\| hypothetical protein BsubsS_08602 [Bacillus subtilis subsp. subtilis...	211.0	[0..25]	[261..2]
gi\|229706429, gi... - gi\|229836361\|ref\|ZP_04456528.1\| siroheme synthase / precorrin-2 oxidase /sirohydrochlorin ferrochela... gi\|21960942, gi\|... - gi\|22127811\|ref\|NP_671234.1\| uroporphyrinogen III methylase [Yersinia pestis KIM], gi\|21960942\|gb\|AA...	211.0	[0..13]	[259..213]
CYSG2_YERPN - Siroheme synthase 2 OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=cysG2 PE=3 SV=1 gi\|161484726 - gi\|161484726\|ref\|NP_671234.2\| siroheme synthase [Yersinia pestis KIM] gi\|165928045, gi... - gi\|165928045\|ref\|ZP_02223877.1\| siroheme synthase [Yersinia pestis biovar Orientalis str. F1991016],... gi\|166010560, gi... - gi\|166010560\|ref\|ZP_02231458.1\| siroheme synthase [Yersinia pestis biovar Antiqua str. E1979001], gi... gi\|166213239, gi... - gi\|166213239\|ref\|ZP_02239274.1\| siroheme synthase [Yersinia pestis biovar Antiqua str. B42003004], g... gi\|167051152, gi... - gi\|167398648\|ref\|ZP_02304172.1\| siroheme synthase [Yersinia pestis biovar Antiqua str. UG05-0454], g... gi\|150260840, gi... - gi\|150260840\|ref\|ZP_01917568.1\| siroheme synthase [Yersinia pestis CA88-4125], gi\|149290248\|gb\|EDM40... gi\|167419358, gi... - gi\|167419358\|ref\|ZP_02311111.1\| siroheme synthase [Yersinia pestis biovar Orientalis str. MG05-1020]... gi\|165936152, gi... - gi\|89105793\|ref\|ZP_01178306.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia pestis biovar Orien... gi\|167425680, gi... - gi\|167425680\|ref\|ZP_02317433.1\| siroheme synthase [Yersinia pestis biovar Mediaevalis str. K1973002]... CYSG_YERPA - Siroheme synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=cysG PE=3 SV=1 gi\|167468236 - gi\|167468236\|ref\|ZP_02332940.1\| siroheme synthase [Yersinia pestis FV-1] gi\|45440022, gi\|... - gi\|45440022\|ref\|NP_991561.1\| siroheme synthase [Yersinia pestis biovar Microtus str. 91001], gi\|4543... CYSG_YERPE - Siroheme synthase OS=Yersinia pestis GN=cysG PE=3 SV=1 gi\|77634599, gi\|... - gi\|77634599\|ref\|ZP_00796696.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia pestis Angola], gi\|... gi\|16120501, gi\|... - gi\|218927369\|ref\|YP_002345244.1\| siroheme synthase [Yersinia pestis CO92], gi\|16120501\|ref\|NP_403814...	210.0	[0..13]	[259..201]
gi\|29895119, gi\|... - gi\|30019575\|ref\|NP_831206.1\| uroporphyrin-III C-methyltransferase [Bacillus cereus ATCC 14579], gi\|2... gi\|229043267, gi... - gi\|229043267\|ref\|ZP_04190989.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus AH676], gi... gi\|229144126, gi... - gi\|229144126\|ref\|ZP_04272541.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus BDRD-ST24]... gi\|229126841, gi... - gi\|229126841\|ref\|ZP_04255853.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus BDRD-Cer4]... gi\|228674452, gi... - gi\|229108983\|ref\|ZP_04238584.1\| Uroporphyrinogen-III C-methyltransferase [Bacillus cereus Rock1-15],...	210.0	[0..23]	[261..1]

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Predicted Domain #1

Region A:
Residues: [1-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIVNIYKRI LSIFNPSLSS LKSKTGITFV GVGPGDPKLL TIAAVEAIKK ATLVAYPVAK  60
   61 LGSKSMASEI ACSFIKNKKC LPIVFPMITD NEALKRAWAF GANKLIEEVK KGEEVVLLSQ 120
  121 GDPSLYSTSA YILLEIKSNF PLIPLKVIPG ISSFNAAAAE AQFPLSLQKE ELLICAVPDN 180
  181 PNHLKEMLDN AIKTKRVLVL IKLGKRWEWV RKVLDEKGLL TKTLFAKRIG FADQLTIKAN 240
  241 NISNEEAPYF SLLIIREDAI F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.30103
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.70810184740502	bayes_pls_golite062009
C-methyltransferase activity	3.49766011792986	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.23847861653053	bayes_pls_golite062009
catalytic activity	1.85393572319476	bayes_pls_golite062009
transferase activity	1.11319893632325	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.934144410066549	bayes_pls_golite062009
methyltransferase activity	0.915475179027344	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.637525028271766	bayes_pls_golite062009
ferrochelatase activity	0.15375007777431	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: