YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS5_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	209 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS5_GEOSL.

Description	E-value	Query Range	Subject Range
gi\|110601328, gi... - gi\|222053794\|ref\|YP_002536156.1\| imidazole glycerol phosphate synthase, glutamine amidotransferase s...	189.0	[0..4]	[209..2]
HIS5_PELCD - Imidazole glycerol phosphate synthase subunit HisH OS=Pelobacter carbinolicus (strain DSM 2380 / Gra...	185.0	[0..4]	[208..2]
gi\|89092431, gi\|... - gi\|89092431\|ref\|ZP_01165385.1\| imidazole glycerol phosphate synthase subunit HisH [Oceanospirillum s...	184.0	[0..1]	[208..1]
gi\|71739782, gi\|... - gi\|71839786\|ref\|ZP_00679528.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	184.0	[0..4]	[205..2]
gi\|88925113, gi\|... - gi\|88945240\|ref\|ZP_01148454.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	183.0	[0..4]	[208..2]
gi\|196252975, gi... - gi\|196252975\|ref\|ZP_03151620.1\| imidazole glycerol phosphate synthase, glutamine amidotransferase su... gi\|125715592, gi... - gi\|67876072\|ref\|ZP_00505104.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	183.0	[0..4]	[205..2]
gi\|88916663, gi\|... - gi\|88936605\|ref\|ZP_01142210.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	182.0	[0..4]	[209..2]
HIS5_METCA - Imidazole glycerol phosphate synthase subunit hisH OS=Methylococcus capsulatus GN=hisH PE=3 SV=1 HIS5_METCA - Imidazole glycerol phosphate synthase subunit HisH OS=Methylococcus capsulatus (strain ATCC 33009 / ...	181.0	[0..1]	[208..1]
HIS5_GEOMG - Imidazole glycerol phosphate synthase subunit HisH OS=Geobacter metallireducens (strain GS-15 / ATCC...	179.0	[0..1]	[205..1]
gi\|46106392, gi\|... - gi\|68561798\|ref\|ZP_00601084.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	178.0	[0..2]	[208..1]

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Predicted Domain #1

Region A:
Residues: [1-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKIAIIDYG MGNLRSVQKG FEKVGFEAVV TADPKVVLEA EKIVLPGVGA FRDCMRNLEQ  60
   61 GGFVEPILRV IREGRPFLGI CVGMQLLLTD SVEFGLYQGL NVIPGHVLRF PEGMREGGEE 120
  121 LKVPHMGWNQ LSIKRRPPAF AEVEDGANVY FVHSYYEMPD DESVIAATCT YGVEFCAAIW 180
  181 KDNIVATQFH PEKSQAVGLS ILKNFGEMK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.221849
Match:	1jvnA
Description:	Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	8.34101262147614	bayes_pls_golite062009
ligase activity	1.70348758031146	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	0.643287540591989	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.628648036096965	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: