YRC Public Data Repository - Protein Structure Prediction

Protein:	MURB_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	288 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MURB_GEOSL.

Description	E-value	Query Range	Subject Range
MURB_STRTD - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus thermophilus (strain ATCC BAA-491 / L...	259.0	[0..4]	[288..17]
gi\|55739428, gi\|... - gi\|55823443\|ref\|YP_141884.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Streptococcus thermophil... gi\|55737500, gi\|... - gi\|55821515\|ref\|YP_139957.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Streptococcus thermophil... gi\|55737500, gi\|... - gb\|AAV63069.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Streptococcus thermophilus CNRZ1066],...	257.0	[0..4]	[288..38]
MURB_STRPC - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M12 (strain MGAS942... MURB_STRPB - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M12 (strain MGAS209...	256.0	[0..4]	[287..9]
MURB_STRP8 - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M18 GN=murB PE=3 SV... MURB_STRP8 - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M18 (strain MGAS823...	255.0	[0..4]	[287..9]
MURB_STRPY - (Q99ZS9) UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) (UDP-N-acetylmuramate dehydrog... MURB_STRP1 - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M1 GN=murB PE=3 SV=... gi\|71853420, gi\|... - gi\|71910638\|ref\|YP_282188.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Streptococcus pyogenes M... gi\|15675084, gi\|... - gi\|15675084\|ref\|NP_269258.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Streptococcus pyogenes M...	255.0	[0..4]	[287..9]
gi\|227071579, gi... - gi\|227363390\|ref\|ZP_03847516.1\| UDP-N-acetylmuramate dehydrogenase [Lactobacillus reuteri MM2-3], gi... gi\|148543639, gi... - gi\|89091641\|ref\|ZP_01164627.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Lactobacillus reuteri ... MURB_LACRJ - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Lactobacillus reuteri (strain JCM 1112) GN=murB PE=... gi\|227193216, gi... - gi\|227532184\|ref\|ZP_03962233.1\| UDP-N-acetylmuramate dehydrogenase [Lactobacillus reuteri MM4-1A], g... MURB_LACRD - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Lactobacillus reuteri (strain DSM 20016) GN=murB PE...	255.0	[0..4]	[288..12]
gi\|91803222, gi\|... - gi\|92090015\|ref\|ZP_01274928.1\| UDP-N-acetylenolpyruvoylglucosamine reductase [Lactobacillus reuteri ...	255.0	[0..4]	[288..12]
gi\|56808703 - gi\|56808703\|ref\|ZP_00366424.1\| COG0812: UDP-N-acetylmuramate dehydrogenase [Streptococcus pyogenes M... MURB_STRPZ - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M49 (strain NZ131) ...	255.0	[0..4]	[287..9]
MURB_STRP6 - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M6 GN=murB PE=3 SV=... MURB_STRP6 - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA... MURB_STRPG - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M5 (strain Manfredo... MURB_STRPF - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M4 (strain MGAS1075...	254.0	[0..4]	[287..9]
MURB_STRPM - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M28 GN=murB PE=3 SV... MURB_STRPM - UDP-N-acetylenolpyruvoylglucosamine reductase OS=Streptococcus pyogenes serotype M28 (strain MGAS618...	254.0	[0..4]	[287..9]

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Predicted Domain #1

Region A:
Residues: [1-288]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGEILRDEP MARHTSLRVG GPADFFVTPA DPDDMRALLA ILAETGTPWL AVGGGYNLLI  60
   61 RDGGFRGVVI SSARMTSLER LEGNRAVVGA GVANGRLTAF LRNEGLAGLE FLCGIPGTVG 120
  121 GALAMNAGAH GGAILDRVEE ILTIGTAGFE CKGRELLDYG YRYLKLQPGE IIIGATFVLD 180
  181 SDDPRRISER IDGCRAHRTA SQQVGFPNAG SFFKNPPGQA AWRLIEDAGL RGARVGGAQV 240
  241 SEVHTNFLVN RGGATAADFL ALAARIKDAV KLKSGTALEE EVKIFGDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.045757
Match:	1hskA
Description:	Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain; Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
UDP-N-acetylmuramate dehydrogenase activity	3.31671992605898	bayes_pls_golite062009
catalytic activity	1.27762227752756	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: