YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|39985031, gi\|...
Organism:	Geobacter sulfurreducens PCA
Length:	236 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|39985031, gi|....

Description	E-value	Query Range	Subject Range
gi\|77962694, gi\|... - gi\|77962694\|ref\|ZP_00826511.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia mollaretii ATCC 439...	210.0	[0..2]	[235..213]
gi\|27316645, gi\|... - gi\|27469096\|ref\|NP_765733.1\| uroporphyrin-III C-methyltransferase [Staphylococcus epidermidis ATCC 1...	209.0	[0..1]	[235..1]
gi\|196158491, gi... - gi\|88794338\|ref\|ZP_01110047.1\| uroporphyrin-III C-methyltransferase [Alteromonas macleodii 'Deep eco...	208.0	[0..5]	[235..236]
gi\|229706429, gi... - gi\|229836361\|ref\|ZP_04456528.1\| siroheme synthase / precorrin-2 oxidase /sirohydrochlorin ferrochela... gi\|21960942, gi\|... - gi\|22127811\|ref\|NP_671234.1\| uroporphyrinogen III methylase [Yersinia pestis KIM], gi\|21960942\|gb\|AA...	207.0	[0..2]	[235..222]
CYSG2_YERPN - Siroheme synthase 2 OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=cysG2 PE=3 SV=1 gi\|161484726 - gi\|161484726\|ref\|NP_671234.2\| siroheme synthase [Yersinia pestis KIM] gi\|165928045, gi... - gi\|165928045\|ref\|ZP_02223877.1\| siroheme synthase [Yersinia pestis biovar Orientalis str. F1991016],... gi\|166010560, gi... - gi\|166010560\|ref\|ZP_02231458.1\| siroheme synthase [Yersinia pestis biovar Antiqua str. E1979001], gi... gi\|166213239, gi... - gi\|166213239\|ref\|ZP_02239274.1\| siroheme synthase [Yersinia pestis biovar Antiqua str. B42003004], g... gi\|167051152, gi... - gi\|167398648\|ref\|ZP_02304172.1\| siroheme synthase [Yersinia pestis biovar Antiqua str. UG05-0454], g... gi\|150260840, gi... - gi\|150260840\|ref\|ZP_01917568.1\| siroheme synthase [Yersinia pestis CA88-4125], gi\|149290248\|gb\|EDM40... gi\|167419358, gi... - gi\|167419358\|ref\|ZP_02311111.1\| siroheme synthase [Yersinia pestis biovar Orientalis str. MG05-1020]... gi\|165936152, gi... - gi\|89105793\|ref\|ZP_01178306.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia pestis biovar Orien... gi\|167425680, gi... - gi\|167425680\|ref\|ZP_02317433.1\| siroheme synthase [Yersinia pestis biovar Mediaevalis str. K1973002]... CYSG_YERPA - Siroheme synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=cysG PE=3 SV=1 gi\|167468236 - gi\|167468236\|ref\|ZP_02332940.1\| siroheme synthase [Yersinia pestis FV-1] gi\|45440022, gi\|... - gi\|45440022\|ref\|NP_991561.1\| siroheme synthase [Yersinia pestis biovar Microtus str. 91001], gi\|4543... CYSG_YERPE - Siroheme synthase OS=Yersinia pestis GN=cysG PE=3 SV=1 gi\|77634599, gi\|... - gi\|77634599\|ref\|ZP_00796696.1\| COG0007: Uroporphyrinogen-III methylase [Yersinia pestis Angola], gi\|... gi\|16120501, gi\|... - gi\|218927369\|ref\|YP_002345244.1\| siroheme synthase [Yersinia pestis CO92], gi\|16120501\|ref\|NP_403814...	206.0	[0..2]	[235..210]
CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis GN=cysG2 PE=3 SV=1 CYSG2_YERPS - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=cysG2 PE=3 SV=1 gi\|170022493, gi... - gi\|170022493\|ref\|YP_001718998.1\| siroheme synthase [Yersinia pseudotuberculosis YPIII], gi\|169749027... CYSG2_YERP3 - Siroheme synthase 2 OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=cysG2 PE=3 SV=...	206.0	[0..2]	[235..213]
CYSG_ECOL5 - Siroheme synthase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=cysG PE=3 SV=1 gi\|191171534, gi... - gi\|75241536\|ref\|ZP_00725381.1\| COG0007: Uroporphyrinogen-III methylase [Escherichia coli F11], gi\|19...	205.0	[0..3]	[236..214]
CYSG_SHIB3 - Siroheme synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=cysG PE=3 SV=1 CYSG_SHIBS - Siroheme synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=cysG PE=3 SV=1	205.0	[0..3]	[236..214]
CYSG_ACIAD - Siroheme synthase OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=cysG PE=3 SV=1	205.0	[0..3]	[235..214]
CYSG_ECO45 - Siroheme synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=cysG PE=3 SV=1 CYSG_ECOK1 - Siroheme synthase OS=Escherichia coli O1:K1 / APEC GN=cysG PE=3 SV=1 CYSG_ECOUT - Siroheme synthase OS=Escherichia coli (strain UTI89 / UPEC) GN=cysG PE=3 SV=1 gi\|226902365, gi... - gi\|237703101\|ref\|ZP_04533582.1\| siroheme synthase [Escherichia sp. 3_2_53FAA], gi\|226902365\|gb\|EEH88...	205.0	[0..3]	[236..214]

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Predicted Domain #1

Region A:
Residues: [1-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGFAKIYAV GVGPGDPELL TRKAERIIRS ADVICAPTGA ADAASYALSI VEDLIDPSRQ  60
   61 EVLPLVFPMR KDQEGLDAFW EDAAAQVAER VRHGRDVAFI TIGDPFLYST FLYLYRIFRE 120
  121 CYPEIAVEIV PGISSITAAA AVAGVPLGMA AERIAILPTT YEDADLRETF ARYDTVVLMK 180
  181 VNRVFDRVYA LLKELGLERC GVFVRRVGSA DEEVVFDLER LVGEKLDYLS LLIVRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.09691
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.70810184740502	bayes_pls_golite062009
C-methyltransferase activity	3.49766011792986	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.23847861653053	bayes_pls_golite062009
catalytic activity	1.85393572319476	bayes_pls_golite062009
transferase activity	1.11319893632325	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.934144410066549	bayes_pls_golite062009
methyltransferase activity	0.915475179027344	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.637525028271766	bayes_pls_golite062009
ferrochelatase activity	0.15375007777431	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: