YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRH_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	239 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRH_GEOSL.

Description	E-value	Query Range	Subject Range
PYRH_CARHZ - Uridylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN=p...	227.0	[0..1]	[239..1]
PYRH_LACJO - Uridylate kinase OS=Lactobacillus johnsonii GN=pyrH PE=3 SV=1 PYRH_LACJO - Uridylate kinase OS=Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) GN=pyrH PE=3 SV=1 gi\|227890235, gi... - gi\|227890235\|ref\|ZP_04008040.1\| uridylate kinase [Lactobacillus johnsonii ATCC 33200], gi\|227849237\|...	227.0	[0..1]	[239..1]
gi\|23002919 - gi\|23002919\|ref\|ZP_00046591.1\| COG0528: Uridylate kinase [Lactobacillus gasseri] gi\|227094235, gi... - gi\|227521138\|ref\|ZP_03951187.1\| uridylate kinase [Lactobacillus gasseri JV-V03], gi\|227094235\|gb\|EEI... gi\|238834756, gi... - gi\|238852610\|ref\|ZP_04643020.1\| UMP kinase [Lactobacillus gasseri 202-4], gi\|238834756\|gb\|EEQ26983.1... PYRH_LACGA - Uridylate kinase OS=Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / ...	226.0	[0..1]	[239..1]
gi\|15292789, gi\|... - gi\|9293891\|dbj\|BAB01794.1\| unnamed protein product [Arabidopsis thaliana], gi\|20258857\|gb\|AAM14100.1...	224.0	[0..4]	[238..94]
gi\|220708047, gi... - gi\|221088054\|ref\|ZP_03557588.1\| uridylate kinase [Geobacillus sp. Y412MC61], gi\|220708047\|gb\|EED6342... PYRH_GEOKA - Uridylate kinase OS=Geobacillus kaustophilus (strain HTA426) GN=pyrH PE=3 SV=1 gi\|229329603, gi... - gi\|229499545\|ref\|ZP_04393229.1\| uridylate kinase [Geobacillus sp. Y412MC52], gi\|229329603\|gb\|EEN9515... PYRH_GEOKA - Uridylate kinase OS=Geobacillus kaustophilus GN=pyrH PE=3 SV=1	224.0	[0..1]	[239..1]
PYRH_ENTFA - Uridylate kinase OS=Enterococcus faecalis (strain ATCC 700802 / V583) GN=pyrH PE=1 SV=1 PYRH_ENTFA - Uridylate kinase OS=Enterococcus faecalis GN=pyrH PE=1 SV=1	223.0	[0..1]	[239..1]
gi\|215740796, gi... - gi\|57900163\|dbj\|BAD88248.1\| putative UMP-kinase [Oryza sativa Japonica Group], gi\|222619931\|gb\|EEE56...	222.0	[0..4]	[236..94]
PYRH_LACSS - Uridylate kinase OS=Lactobacillus sakei subsp. sakei (strain 23K) GN=pyrH PE=3 SV=1	220.0	[0..1]	[239..1]
PYRH_FUSNN - Uridylate kinase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8... PYRH_FUSNN - Uridylate kinase OS=Fusobacterium nucleatum subsp. nucleatum GN=pyrH PE=3 SV=1	219.0	[0..1]	[239..1]
gi\|71489035, gi\|... - gi\|71545020\|ref\|ZP_00665985.1\| Aspartate/glutamate/uridylate kinase [Syntrophobacter fumaroxidans MP...	219.0	[0..2]	[238..54]

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Predicted Domain #1

Region A:
Residues: [1-239]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTPYYGRVL LKLSGEALAG DQGYGIDPRT ITAIAAEIKE VVATGSQLAL VIGGGNIFRG  60
   61 LAASSKGMDR ASADYMGMLA TMINSLAMQD ALEKVGVDTR VQSAIAMQEV AEPYIRRRAI 120
  121 RHLEKGRIVI FGAGTGNPYF TTDTAASLRA MEIGADVILK GTKVDGVYSA DPKKDPTAIK 180
  181 YPRLTYLEVL KKGLQVMDAT ATSLCMDNNL PIIVFDITTY GNIKKVVCGE EIGTIVKGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.522879
Match:	1z9dA
Description:	Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
kinase activity	5.43826659128409	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	4.76215533422168	bayes_pls_golite062009
nucleotide kinase activity	4.36245911991838	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.17538459617947	bayes_pls_golite062009
uridylate kinase activity	3.54453921304057	bayes_pls_golite062009
catalytic activity	3.20382750184555	bayes_pls_golite062009
transferase activity	2.54481238004476	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.89315414622708	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	1.02979719559565	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: