YRC Public Data Repository - Protein Structure Prediction

Protein:	THIE_GEOSL
Organism:	Geobacter sulfurreducens PCA
Length:	213 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THIE_GEOSL.

Description	E-value	Query Range	Subject Range
THIE_SYNWW - Thiamine-phosphate synthase OS=Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) G...	161.0	[0..1]	[208..1]
gi\|92885240 - gi\|92885240\|gb\|ABE87727.1\| Thiamine monophosphate synthase; Phosphomethylpyrimidine kinase [Medicago...	157.0	[0..5]	[210..365]
THIE_METAR - Thiamine-phosphate synthase OS=Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) GN=th...	156.0	[0..4]	[210..1]
THIE_SYNY3 - Thiamine-phosphate synthase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=thiE PE=3 SV=1 gi\|7427960 - pir\|\|S74943 thiamine-phosphate diphosphorylase (EC 2.5.1.3) - Synechocystis sp. (strain PCC 6803) THIE_SYNY3 - Thiamine-phosphate pyrophosphorylase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=th...	155.0	[0..4]	[208..141]
gi\|23130348 - gi\|23130348\|ref\|ZP_00112165.1\| COG0352: Thiamine monophosphate synthase [Nostoc punctiforme PCC 7310...	154.0	[0..7]	[210..170]
gi\|78218829, gi\|... - gi\|78356424\|ref\|YP_387873.1\| thiamine-phosphate pyrophosphorylase [Desulfovibrio desulfuricans subsp...	153.0	[0..2]	[212..1]
gi\|78044820, gi\|... - gi\|78044820\|ref\|YP_359600.1\| thiamine-phosphate pyrophosphorylase [Carboxydothermus hydrogenoformans...	153.0	[0..4]	[211..157]
gi\|48891748, gi\|... - gi\|71674938\|ref\|ZP_00672684.1\| Thiamine monophosphate synthase [Trichodesmium erythraeum IMS101], gi...	153.0	[0..4]	[209..147]
gi\|78224131, gi\|... - gi\|78224131\|ref\|YP_385878.1\| thiamine monophosphate synthase [Geobacter metallireducens GS-15], gi\|7...	153.0	[0..1]	[213..1]

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Predicted Domain #1

Region A:
Residues: [1-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKVDFSLYL ITDRHQAGGR DLLAVVEGAL AGGVRCVQLR EKDLPARTLL ELARAMRRLT  60
   61 DRFGARLLIN DRVDIALAAG ADGVHLGEEG MPAAVARELL GSGRLIGVSC HGRGGAAAAV 120
  121 AQGADFITFG PVYPTPSKAA YGEPVGIDQL AATTKEIHIP VFALGGIKEA NIPEALAAGA 180
  181 AGVALISAII ADPDPRERAR ALLALLPPRT RDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.0
Match:	1xi3A
Description:	Thiamine phosphate pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.41302536847612	bayes_pls_golite062009
transferase activity	0.53602265668859	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	0.132181770667541	bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity	0.11808794154144	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: