YRC Public Data Repository - Protein Structure Prediction

Protein:	BIOC2_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	248 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BIOC2_COXBU.

Description	E-value	Query Range	Subject Range
gi\|78364606, gi\|... - gi\|78486320\|ref\|YP_392245.1\| biotin biosynthesis protein BioC [Thiomicrospira crunogena XCL-2], gi\|7...	178.0	[0..2]	[244..1]
gi\|28806102, gi\|... - gi\|28897889\|ref\|NP_797494.1\| biotin synthesis protein BioC [Vibrio parahaemolyticus RIMD 2210633], g... gi\|28806102 - gi\|28806102\|dbj\|BAC59378.1\| biotin synthesis protein BioC [Vibrio parahaemolyticus RIMD 2210633] gi\|149748333, gi... - gi\|153838278\|ref\|ZP_01990945.1\| biotin biosynthesis protein BioC [Vibrio parahaemolyticus AQ3810], g...	176.0	[0..2]	[244..11]
gi\|218321183, gi... - gi\|218708164\|ref\|YP_002415785.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Vibrio splen... gi\|85835662, gi\|... - gi\|86146605\|ref\|ZP_01064927.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Vibrio sp. MED...	173.0	[0..4]	[222..32]
gi\|84386296, gi\|... - gi\|84386296\|ref\|ZP_00989324.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Vibrio splendi...	173.0	[0..4]	[222..32]
MENG_STAA1 - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain Mu3 / ATCC 700698) GN=menG PE... MENG_STAAW - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain MW2) GN=menG PE=3 SV=1 MENG_STAAE - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain Newman) GN=menG PE=3 SV=1 MENG_STAA9 - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain JH9) GN=menG PE=3 SV=1 gi\|269203096\|ref... - ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcus aureus subsp. aureus ED98] gi\|25304996 - pir\|\|G89925 menaquinone biosynthesis methyltransferase [imported] - Staphylococcus aureus (strain N3... MENG_STAAT - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain USA300 / TCH1516) GN=menG PE=... gi\|221140962 - gi\|221140962\|ref\|ZP_03565455.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... MENG_STAAS - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain MSSA476) GN=menG PE=3 SV=1 gi\|221138325 - gi\|221138325\|ref\|ZP_03563127.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... MENG_STAAM - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=menG P... MENG_STAAN - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain N315) GN=menG PE=1 SV=1 gi\|251802063, gi... - gi\|251814398\|ref\|ZP_04828871.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... gi\|253315978 - gi\|253315978\|ref\|ZP_04839191.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... gi\|253732113, gi... - gi\|253732113\|ref\|ZP_04866278.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... gi\|253728822, gi... - gi\|253733282\|ref\|ZP_04867447.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... gi\|255006257 - gi\|255006257\|ref\|ZP_05144858.2\| ubiquinone/menaquinone biosynthesis methyltransferase [Staphylococcu... MENG_STAA2 - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain JH1) GN=menG PE=3 SV=1 MENG_STAAC - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain COL) GN=menG PE=3 SV=1	172.0	[0..4]	[223..5]
gi\|91224931, gi\|... - gi\|91224931\|ref\|ZP_01260190.1\| ubiquinone/menaquinone biosynthesis methyltransferase [Vibrio alginol...	171.0	[0..4]	[222..27]
UBIE_VIBVU - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE OS=Vibrio vulnificus (strain CMCP6) GN=... UBIE_VIBVY - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE OS=Vibrio vulnificus (strain YJ016) GN=... UBIE_VIBVU - Ubiquinone/menaquinone biosynthesis methyltransferase ubiE OS=Vibrio vulnificus GN=ubiE PE=3 SV=1	171.0	[0..4]	[222..28]
MENG_STAAB - Demethylmenaquinone methyltransferase OS=Staphylococcus aureus (strain bovine RF122 / ET3-1) GN=menG...	171.0	[0..4]	[223..5]
gi\|116185709, gi... - gi\|75856470\|ref\|ZP_00764098.1\| COG2226: Methylase involved in ubiquinone/menaquinone biosynthesis [V...	171.0	[0..4]	[222..27]

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Predicted Domain #1

Region A:
Residues: [1-248]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMVNSLKKRI QRSFNKAFDT YDDHASIQRE ICKQLLKPLK EMRIQTKIIA DFACGTGIST  60
   61 KAVADSFPYQ NLYAIDFCEK LLIQAKSKLK ESNVEFILAD FETNVFLCNS LDLIFCNMGF 120
  121 QWALDLKQTF FSLFSQLKAF GVLAFSVPLL GTFCELRNDC RNPFLTLQSI VQLLKAVGFE 180
  181 LLTADEKIFT DSFESPLDAI RSIKSIGANC LLYPKRNKGL SPMPIEKNNT DTTLTYHIGF 240
  241 FIAKKIIQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.69897
Match:	2avnA
Description:	Crystal structure of Ubiquinone/menaquinone biosynthesis methyltransferase-related protein (tm1389) from THERMOTOGA MARITIMA at 2.35 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.62377578202456	bayes_pls_golite062009
transferase activity	1.27388514102581	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.11446137064593	bayes_pls_golite062009
methyltransferase activity	1.0967819849268	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.495483488913306	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: