YRC Public Data Repository - Protein Structure Prediction

Protein:	PANB_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	266 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PANB_COXBU.

Description	E-value	Query Range	Subject Range
gi\|27262460 - gi\|27262460\|gb\|AAN87511.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Heliobacillus mobilis]	417.0	[0..2]	[262..3]
gi\|85859368, gi\|... - gi\|85859368\|ref\|YP_461570.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Syntrophus aciditroph...	416.0	[0..3]	[266..15]
gi\|88926139, gi\|... - gi\|88944133\|ref\|ZP_01147466.1\| Ketopantoate hydroxymethyltransferase [Desulfotomaculum reducens MI-1...	416.0	[0..2]	[266..3]
gi\|147676555, gi... - gi\|98661989\|dbj\|GAA01057.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476765...	413.0	[0..2]	[266..4]
PANB_GEOMG - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Geobacter metallireducens (strain GS-15 / ATCC 5...	407.0	[0..5]	[266..6]
PANB_THEPX - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Thermoanaerobacter sp. (strain X514) GN=panB PE=... gi\|242232265, gi... - gi\|242256188\|ref\|ZP_04801083.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Thermoanaerobacter... gi\|241903490, gi... - gi\|241903490\|ref\|ZP_04788213.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Thermoanaerobacter... PANB_THEP3 - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Thermoanaerobacter pseudethanolicus (strain ATCC...	406.0	[0..2]	[266..3]
gi\|154356691, gi... - gi\|94491082\|ref\|ZP_01298301.1\| hypothetical protein CburD_01001813 [Coxiella burnetii Dugway 7E9-12]... gi\|161762678, gi... - gi\|95927212\|ref\|ZP_01309974.1\| hypothetical protein CburR_01000983 [Coxiella burnetii RSA 331], gi\|1...	406.0	[0..4]	[266..1]
PANB_CARHZ - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Carboxydothermus hydrogenoformans (strain ATCC B...	405.0	[0..1]	[266..1]
SO0870 - 3-methyl-2-oxobutanoate hydroxymethyltransferase PANB_SHEON - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Shewanella oneidensis (strain MR-1) GN=panB PE=3...	403.0	[0..1]	[266..1]

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Predicted Domain #1

Region A:
Residues: [1-266]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIAMNTPDFQ RMKKDNKKIS MVTCYDYWSA CIISQSNVDC ILVGDSLAMV MYGHSTTLPA  60
   61 TVEIMAQHIQ AVSRGAPNKF IIGDMPFCSY RKDLTTSMNA VERLMQAGAQ AIKLEGADAH 120
  121 NLKFIHHVVK SGIPVIGHLG LTPQSIYTLG GFKVQGKEPS AAKKLMADAK ALAETGCFAV 180
  181 VLECVPSELA ELITHSISIP TIGIGAGPAT SGQVLVLQDL LGTNNQFQPK YLKKFLNGFE 240
  241 LIKKALDDFD QEVKTSTYPH LETHCY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	108.0
Match:	1m3uA
Description:	Ketopantoate hydroxymethyltransferase PanB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-methyl-2-oxobutanoate hydroxymethyltransferase activity	4.08693637310631	bayes_pls_golite062009
catalytic activity	2.59838799615646	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	2.05689968523792	bayes_pls_golite062009
transferase activity	1.07154136609184	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.646649320021871	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.366715189574293	bayes_pls_golite062009
oxo-acid-lyase activity	0.0960362356555544	bayes_pls_golite062009
carbon-carbon lyase activity	0.0846611486307003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: