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View Structure Prediction Details

Protein: HGNC:8506|MIM:16...
Organism: SPECIES UNKNOWN
Length: 252 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:8506|MIM:16....

Description E-value Query
Range		 Subject
Range
gi|60834962 - gi|60834962|gb|AAX37118.1| oncostatin M [synthetic construct]
 0.0 [1..252] [1..252]
gi|114685834 - gi|114685834|ref|XP_001136178.1| PREDICTED: similar to Oncostatin M precursor (OSM) [Pan troglodytes...
 0.0 [1..252] [1..252]
gi|109093951 - gi|109093951|ref|XP_001110148.1| PREDICTED: similar to oncostatin M precursor [Macaca mulatta]
 6.0E-99 [1..252] [1..252]
ONCM_RAT - Oncostatin-M OS=Rattus norvegicus GN=Osm PE=2 SV=1
gi|55741439 - ref|NP_001006962.1| oncostatin M [Rattus norvegicus]
 2.0E-96 [1..252] [1..239]
gi|10835824 - gi|10835824|pdb|1EVS|A Chain A, Crystal Structure Of Human Oncostatin M
 2.0E-86 [26..212] [1..187]
ONCM_BOVIN - Oncostatin-M OS=Bos taurus GN=OSM PE=3 SV=1
 4.0E-84 [1..251] [1..236]
ONCM_MOUSE - Oncostatin-M OS=Mus musculus GN=Osm PE=1 SV=1
gi|1256923 - gi|1256923|dbj|BAA06712.1| mouse oncostatin M [Mus cookii]
 1.0E-80 [26..243] [23..228]
gi|73995418 - gi|73995418|ref|XP_854737.1| PREDICTED: similar to oncostatin M precursor [Canis familiaris]
 3.0E-72 [9..250] [30..257]

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Predicted Domain #1
Region A:
Residues: [1-252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVLLTQRTL LSLVLALLFP SMASMAAIGS CSKEYRVLLG QLQKQTDLMQ DTSRLLDPYI  60
   61 RIQGLDVPKL REHCRERPGA FPSEETLRGL GRRGFLQTLN ATLGCVLHRL ADLEQRLPKA 120
  121 QDLERSGLNI EDLEKLQMAR PNILGLRNNI YCMAQLLDNS DTAEPTKAGR GASQPPTPTP 180
  181 ASDAFQRKLE GCRFLHGYHR FMHSVGRVFS KWGESPNRSR RHSPHQALRK GVRRTRPSRK 240
  241 GKRLMTRGQL PR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.69897
Match: 1evsA
Description: Oncostatin M
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ciliary neurotrophic factor receptor binding 7.7149955236337 bayes_pls_golite062009
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.1883241815362 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
oncostatin-M receptor binding 4.90961029698962 bayes_pls_golite062009
protein binding 3.52041127390038 bayes_pls_golite062009
binding 2.74412602806415 bayes_pls_golite062009
hormone activity 2.52921243340076 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
growth hormone activity 2.40761961528911 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
macrophage colony stimulating factor receptor binding 1.79494229909143 bayes_pls_golite062009
interleukin-10 receptor binding 1.70583547295961 bayes_pls_golite062009
signal transducer activity 1.52819399447638 bayes_pls_golite062009
molecular transducer activity 1.52819399447638 bayes_pls_golite062009
erythropoietin receptor binding 1.40250979351968 bayes_pls_golite062009
interleukin-5 receptor binding 0.89757450102906 bayes_pls_golite062009
interleukin-27 binding 0.47086358315465 bayes_pls_golite062009
interleukin-12 binding 0.30601802121141 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle