YRC Public Data Repository - Protein Structure Prediction

Protein:	NHAP2_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	574 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NHAP2_SHEON.

Description	E-value	Query Range	Subject Range
gi\|149740788, gi... - gi\|153825503\|ref\|ZP_01978170.1\| conserved hypothetical protein [Vibrio cholerae MZO-2], gi\|149740788... CVRA_VIBCH - Cell volume regulation protein A homolog OS=Vibrio cholerae GN=cvrA PE=3 SV=1 NHAP2_VIBCH - K(+)/H(+) antiporter NhaP2 OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) ... gi\|229507248, gi... - gi\|229507248\|ref\|ZP_04396753.1\| hypothetical protein VCF_002471 [Vibrio cholerae BX 330286], gi\|2293... gi\|229346016, gi... - gi\|229516953\|ref\|ZP_04406399.1\| hypothetical protein VCC_000972 [Vibrio cholerae RC9], gi\|229346016\|... NHAP2_VIBCM - K(+)/H(+) antiporter NhaP2 OS=Vibrio cholerae serotype O1 (strain M66-2) GN=nhaP2 PE=3 SV=1 gi\|229527371, gi... - gi\|229527371\|ref\|ZP_04416763.1\| hypothetical protein VCG_000436 [Vibrio cholerae 12129(1)], gi\|22933... gi\|229606754, gi... - gi\|229606754\|ref\|YP_002877402.1\| hypothetical protein VCD_001663 [Vibrio cholerae MJ-1236], gi\|22936... gi\|121586613, gi... - gi\|121586613\|ref\|ZP_01676398.1\| conserved hypothetical protein [Vibrio cholerae 2740-80], gi\|1215491... gi\|153221031, gi... - gi\|153221031\|ref\|ZP_01952086.1\| conserved hypothetical protein [Vibrio cholerae MAK 757], gi\|1241199... gi\|153212535, gi... - gi\|153212535\|ref\|ZP_01948282.1\| conserved hypothetical protein [Vibrio cholerae 1587], gi\|124116406\|... gi\|229509831, gi... - gi\|229509831\|ref\|ZP_04399312.1\| hypothetical protein VCE_001233 [Vibrio cholerae B33], gi\|229353305\|... gi\|125619231, gi... - gi\|254851240\|ref\|ZP_05240590.1\| potassium/proton antiporter [Vibrio cholerae MO10], gi\|254846945\|gb\|...	302.0	[0..1]	[573..1]
gi\|91228456, gi\|... - gi\|91228456\|ref\|ZP_01262380.1\| potassium/proton antiporter [Vibrio alginolyticus 12G01], gi\|91187991...	297.0	[0..1]	[573..1]
CVRA_VIBPA - Cell volume regulation protein A homolog OS=Vibrio parahaemolyticus GN=cvrA PE=3 SV=1 NHAP2_VIBPA - K(+)/H(+) antiporter NhaP2 OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=nhaP2 ...	295.0	[0..1]	[571..1]
gi\|75827947 - gi\|75827947\|ref\|ZP_00757382.1\| COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-termi... gi\|75815749 - gi\|75815749\|ref\|ZP_00746243.1\| COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-termi...	295.0	[0..12]	[573..2]
gi\|116190692, gi... - gi\|75830629\|ref\|ZP_00759903.1\| COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-termi...	295.0	[0..12]	[573..2]
gi\|116221328, gi... - gi\|75818188\|ref\|ZP_00748390.1\| COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-termi...	295.0	[0..12]	[573..2]
gi\|194538825, gi... - gi\|75854815\|ref\|ZP_00762487.1\| COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-termi...	293.0	[0..1]	[573..1]
gi\|75824736, gi\|... - gi\|75824736\|ref\|ZP_00754182.1\| COG3263: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-termi...	293.0	[0..12]	[573..2]
CVRA_YERPS - Cell volume regulation protein A OS=Yersinia pseudotuberculosis GN=cvrA PE=3 SV=1 NHAP2_YERPY - K(+)/H(+) antiporter NhaP2 OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=nhaP2 PE=3 ... NHAP2_YERP3 - K(+)/H(+) antiporter NhaP2 OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=nhaP2 P... NHAP2_YERPS - K(+)/H(+) antiporter NhaP2 OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=nhaP2 PE=3 ...	291.0	[0..1]	[573..1]
NHAP2_SHESA - K(+)/H(+) antiporter NhaP2 OS=Shewanella sp. (strain ANA-3) GN=nhaP2 PE=3 SV=1	291.0	[0..1]	[574..1]

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Predicted Domain #1

Region A:
Residues: [1-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDADSINSFF LIGALLTAVS VLLSPMSSRL GIPILLIFLA VGILAGEDGP GGILFDDYST  60
   61 AYLVSNFALA IILLDGGMRT RVASFRVALW PALSLATFGV AITTSITGVM AAWLFDLHWL 120
  121 QGLLVGAIVG STDAAAVFSL LKGRSLNERV GATLEIESGS NDPMAVFLTV TLIAILANVG 180
  181 AELSASFMLI SFIKQFG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [198-396]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGVLLGLGGG WLLWKLVNVS KLAEGLYSIL VLSGGLMIYA TSNKLGGSGI LSIYLVGLFL  60
   61 GNKPTRGRHA ILNVLDGMTW VSQIGMFLVL GLLLTPSDLL DIWLPGLALA FGMILFARPL 120
  121 AVWLSLLPFK SFGSRDRWFI SWVGLRGAVP IILAVFPMMA GLPGAQLYFN LAFFVVIVSL 180
  181 LVQGASLTTA ARLAKVELP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [397-487]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKPLPISRSG VEIYPKSEWE VFVYCLSESK WCIGEPLKRL AMPDGTRIAA VFRNNTLLHP  60
   61 SGSTCLEAGD ILCVLGQEKS LEALSNLFSQ A

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.02
Match:	1vctA
Description:	Crystal structure of putative potassium channel related protein from Pyrococcus horikoshii
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [488-574]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PETDEVSRFF GDFFIDTEVK LADLAPIYGL TLDDETGAMT VADLVALELG AHPVLGDQFL  60
   61 WQSLHWVVAG LYEGKVTNVG IRLPADA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.30103
Match:	2oaiA
Description:	No description for 2oaiA was found.

Predicted functions:

Term	Confidence	Notes
metal ion transmembrane transporter activity	3.20360029620216	bayes_pls_golite062009
ion transmembrane transporter activity	2.84728629370153	bayes_pls_golite062009
cation transmembrane transporter activity	2.83549234777732	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.62479915553705	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.09656284183303	bayes_pls_golite062009
transporter activity	1.41639006729672	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	1.21441469552217	bayes_pls_golite062009
transmembrane transporter activity	1.13866512878605	bayes_pls_golite062009
substrate-specific transporter activity	0.917464827903503	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.650200302890589	bayes_pls_golite062009
binding	0.57037105268889	bayes_pls_golite062009
catalytic activity	0.074501016141151	bayes_pls_golite062009
magnesium ion transmembrane transporter activity	0.0317663613487458	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: