YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24373458, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	315 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24373458, gi|....

Description	E-value	Query Range	Subject Range
gi\|28277949, gi\|... - gi\|41055014\|ref\|NP_957509.1\| 3-hydroxy-3-methylglutaryl CoA lyase [Danio rerio], gi\|28277949\|gb\|AAH4...	317.0	[0..8]	[308..35]
gi\|73973416 - gi\|73973416\|ref\|XP_538973.2\| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase...	316.0	[0..8]	[310..35]
HMGCL_MACFA - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Macaca fascicularis GN=HMGCL PE=2 SV=1	316.0	[0..6]	[308..18]
HMGCL_BOVIN - Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Bos taurus GN=HMGCL PE=2 SV=2	315.0	[0..6]	[308..18]
HMGC2_MOUSE - 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic OS=Mus musculus GN=Hmgcll1 PE=2 SV=1	314.0	[0..7]	[310..34]
HMGCL - 3-hydroxymethyl-3-methylglutaryl-CoA lyase gi\|123982536, gi... - gi\|60654789\|gb\|AAX31959.1\| 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase [synthetic construct], ...	314.0	[0..6]	[308..18]
gi\|47219546 - gi\|47219546\|emb\|CAG09900.1\| unnamed protein product [Tetraodon nigroviridis]	314.0	[0..16]	[308..40]
gi\|114554640 - gi\|114554640\|ref\|XP_513200.2\| PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyas...	313.0	[0..1]	[308..4]

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Predicted Domain #1

Region A:
Residues: [1-315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAQDLSNLS ATSLSATSDS VSLFEMGPRD GLQNEAAVPT QAKVALIEAL ANAGVKRIEA  60
   61 GSFVSPKWVP QMADSGEVLR QIRRQAGVVY SALTPNVKGL ELALDAKASE VAIFGAASQS 120
  121 FSQRNINCSI EESIERFIPL MDMAKAANIP VRGYVSCVLG CPYEGEIAAS EVARVSEILY 180
  181 KMGCYEISLG DTIGVGTPLK ARKMLQAVME RVPVEKLALH FHDTYGQALA NITACLDLGV 240
  241 RSFDASVAGL GGCPYAKGAS GNLASEDLVY MLHGLGLKTG IDLEKLALAG FGISKQLNRL 300
  301 NGSKVANAIL QGAKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.39794
Match:	2cw6A
Description:	Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits