YRC Public Data Repository - Protein Structure Prediction

Protein:	HUTH_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	513 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HUTH_SHEON.

Description	E-value	Query Range	Subject Range
PAL1_PRUAV - Phenylalanine ammonia-lyase 1 OS=Prunus avium GN=PAL1 PE=2 SV=1	677.0	[0..3]	[501..53]
gi\|7798554 - gi\|7798554\|dbj\|BAA95629.1\| phenylalanine ammonia lyase [Catharanthus roseus]	675.0	[0..3]	[501..51]
gi\|4808126 - gi\|4808126\|emb\|CAB42793.1\| phenylalanine-ammonia lyase [Citrus clementina x Citrus reticulata]	673.0	[0..3]	[502..56]
gi\|75817907, gi\|... - gi\|75817907\|ref\|ZP_00748163.1\| COG2986: Histidine ammonia-lyase [Vibrio cholerae V51], gi\|254227067\|...	672.0	[0..4]	[512..1]
HUTH_THETN - Histidine ammonia-lyase OS=Thermoanaerobacter tengcongensis GN=hutH PE=3 SV=1 HUTH_CALS4 - Histidine ammonia-lyase OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JC...	672.0	[0..4]	[505..1]
gi\|34541972 - gi\|34541972\|gb\|AAQ74878.1\| phenylalanine ammonia lyase [Populus balsamifera subsp. trichocarpa x Pop...	672.0	[0..3]	[502..47]
gi\|7208616 - gi\|7208616\|gb\|AAF40224.1\|AF237955_1 phenylalanine ammonia-lyase 2 [Rubus idaeus]	672.0	[0..3]	[501..66]
gi\|14486430 - gi\|14486430\|gb\|AAK62030.1\| phenylalanine ammonia-lyase 1 [Manihot esculenta]	672.0	[0..3]	[502..46]
gi\|71277049 - gi\|71277049\|gb\|AAZ29735.1\| phenylalanine ammonia lyase [Trifolium pratense]	671.0	[0..3]	[502..62]
PALY_POPTR - Phenylalanine ammonia-lyase OS=Populus trichocarpa GN=PAL PE=2 SV=1 gi\|169454, gi\|541843 - gi\|541843\|pir\|\|JQ2265 phenylalanine ammonia-lyase (EC 4.3.1.5) - western balsam poplar x cottonwood,...	671.0	[0..3]	[501..50]

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Predicted Domain #1

Region A:
Residues: [1-513]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSVNHLVLT PGSLSLAQLR EISRHKLTLE LAPEAINDIN ISAQIVQKVL DEGRTVYGIN  60
   61 TGFGLLANTK IAPEDLQLLQ RSIVLSHAAG TGQYMQDATV RLMMVLKINS LSRGFSGIRL 120
  121 EVINFLISLV NAEVYPCVPE KGSVGASGDL APLAHMCLPL LGEGEMSYQG QIISAAEGLE 180
  181 IAGLKPIDLA AKEGLALLNG TQASTALALE GLFHAEDLFA ASSVIGAMSV EAAMGSRSPF 240
  241 DPRIHAARGQ KGQIDSAMVF RYLLGEESEI SLSHANCEKV QDPYSLRCQP QVLGACLTQI 300
  301 RQAAEVLATE ANGVTDNPLV FQDTGDIISG GNFHAEPVAM AADNLAIAIA ELGAIAERRI 360
  361 ALLIDSSLSK LPPFLVKNGG VNSGFMIAQV TAAALASENK TYAHPASVDS LPTSANQEDH 420
  421 VSMATFAARR LRDMSENTRG VLAIELLAAA QGLDFRAPLT PSKAVAQAKA ELREVVAYYD 480
  481 KDRYFAPDIE AATDLLYTAS FNAYLPLGVL PSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1b8fA
Description:	Histidine ammonia-lyase (HAL)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histidine ammonia-lyase activity	3.53226750625841	bayes_pls_golite062009
catalytic activity	2.51282259572665	bayes_pls_golite062009
lyase activity	2.31268471569846	bayes_pls_golite062009
carbon-nitrogen lyase activity	2.2046475419807	bayes_pls_golite062009
amidine-lyase activity	0.901614580251298	bayes_pls_golite062009
argininosuccinate lyase activity	0.617974375213548	bayes_pls_golite062009
ammonia-lyase activity	0.491229595527877	bayes_pls_golite062009
fumarate hydratase activity	0.364320954362762	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: