YRC Public Data Repository - Protein Structure Prediction

Protein:	EFM2_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EFM2_YEAST.

Description	E-value	Query Range	Subject Range
YBR271W - Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green flu... EFM2_YEAST - Protein-lysine N-methyltransferase EFM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...	0.0	[1..419]	[1..419]
gi\|14585877, gi\|... - gi\|42475946\|ref\|NP_963892.1\| hypothetical protein LOC196483 isoform 2 [Homo sapiens], gi\|14585877\|gb...	1.0E-48	[126..401]	[6..279]
SPAC3A11.03 - methyltransferase YEZ3_SCHPO - Uncharacterized protein C3A11.03 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3A11....	4.0E-33	[100..343]	[28..243]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-32	[101..343]	[1..215]
ANM11_ARATH - Protein arginine N-methyltransferase 1.1 OS=Arabidopsis thaliana GN=PRMT11 PE=1 SV=1	6.0E-31	[230..419]	[84..267]

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Predicted Domain #1

Region A:
Residues: [1-89]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDPLDLYTP DDIQVEALQF NLAEREPKDP CSPQRDEILT AVDEEESDDD DTIIDNLDLP  60
   61 SVKYAPPEVI LCILILLKPD RQVNFNQET

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [90-192]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKNKSVLEVC KSHGLEPDLL KRLLTWYTEE WPNKRLNSLE KICNKIPMLR FTVSKELLLG  60
   61 YYTSVLKKYN NSCGLNEEII QELLKELSSR ISENCGRTAQ PSI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transferase activity	0.569065423404044	bayes_pls_golite062009
catalytic activity	0.486907672100804	bayes_pls_golite062009
methyltransferase activity	0.155495931533276	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.145822362574272	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [193-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRYFELRNLS TSIPLHEPSL TADNLGWKTW GSSLILSQLV VDHLDYLHTT NVNMLANSDI  60
   61 KQIKVLELGA GTGLVGLSWA LKWKELYGTE NIEIFVTDLP EIVTNLKKNV SLNNLGDFVQ 120
  121 AEILDWTNPH DFIDKFGHEN EFDVILIADP IYSPQHPEWV VNMISKFLAA SGTCHLEIPL 180
  181 RAKYAKEREV LKLLLKESDL KVVEERHSEG VDDWGAVKYL YRQIVRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.39794
Match:	1f3lA_
Description:	Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: