YRC Public Data Repository - Protein Structure Prediction

Protein:	NUG1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	520 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUG1_YEAST.

Description	E-value	Query Range	Subject Range
NUG1_YEAST - Nuclear GTP-binding protein NUG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUG1 PE... NUG1 - GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits...	3.0E-84	[1..520]	[1..520]
DER_SYNY3, ENGA_... - GTP-binding protein engA OS=Synechocystis sp. (strain PCC 6803) GN=engA PE=3 SV=1, GTPase Der OS=Syn... DER_SYNY3 - GTPase Der OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=der PE=3 SV=1 gi\|7450580 - pir\|\|S75645 probable GTP binding protein slr1974 - Synechocystis sp. (strain PCC 6803)	2.0E-60	[88..505]	[6..423]
DER_NOSS1 - GTPase Der OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=der PE=3 SV=1 gi\|25328280 - pir\|\|AB1867 GTP binding protein [imported] - Nostoc sp. (strain PCC 7120)	8.0E-60	[88..505]	[6..423]
DER_STRR6 - GTPase Der OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=der PE=3 SV=1 DER_STRPN - GTPase Der OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=der PE=3 SV=1 DER_STRP2 - GTPase Der OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) GN=der PE=3 SV=1 gi\|149011426, gi... - gi\|149011426\|ref\|ZP_01832673.1\| phosphoglycerate dehydrogenase-related protein [Streptococcus pneumo... DER_STRPI - GTPase Der OS=Streptococcus pneumoniae (strain Hungary19A-6) GN=der PE=3 SV=1 gi\|148997762, gi... - gi\|148997762\|ref\|ZP_01825326.1\| phosphoglycerate dehydrogenase-related protein [Streptococcus pneumo... DER_STRPS - GTPase Der OS=Streptococcus pneumoniae (strain CGSP14) GN=der PE=3 SV=1 gi\|148989364, gi... - gi\|148989364\|ref\|ZP_01820732.1\| phosphoglycerate dehydrogenase-related protein [Streptococcus pneumo... DER_STRP4 - GTPase Der OS=Streptococcus pneumoniae serotype 19F (strain G54) GN=der PE=3 SV=1 DER_STRPJ - GTPase Der OS=Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) GN=der PE=3 SV=1 ENGA_STRPN, DER_... - GTP-binding protein engA OS=Streptococcus pneumoniae GN=engA PE=3 SV=1, GTPase Der OS=Streptococcus ... gi\|168487543, gi... - gi\|183569654\|gb\|EDT90182.1\| GTP-binding protein EngA [Streptococcus pneumoniae CDC1087-00], gi\|16848... gi\|183574158, gi... - gi\|183574158\|gb\|EDT94686.1\| GTP-binding protein EngA [Streptococcus pneumoniae CDC0288-04], gi\|16849... gi\|168493616, gi... - gi\|183576280\|gb\|EDT96808.1\| GTP-binding protein EngA [Streptococcus pneumoniae CDC3059-06], gi\|16849... gi\|183578800, gi... - gi\|183578800\|gb\|EDT99328.1\| GTP-binding protein EngA [Streptococcus pneumoniae MLV-016], gi\|16857510... DER_STRZJ - GTPase Der OS=Streptococcus pneumoniae (strain JJA) GN=der PE=3 SV=1 gi\|149020788, gi... - gi\|149020788\|ref\|ZP_01835317.1\| phosphoglycerate dehydrogenase-related protein [Streptococcus pneumo... DER_STRZT - GTPase Der OS=Streptococcus pneumoniae (strain Taiwan19F-14) GN=der PE=3 SV=1 gi\|237649250 - gi\|237649250\|ref\|ZP_04523502.1\| GTP-binding protein EngA [Streptococcus pneumoniae CCRI 1974] DER_STRZP - GTPase Der OS=Streptococcus pneumoniae (strain P1031) GN=der PE=3 SV=1 DER_STRP7 - GTPase Der OS=Streptococcus pneumoniae (strain 70585) GN=der PE=3 SV=1 gi\|237822010 - gi\|237822010\|ref\|ZP_04597855.1\| GTP-binding protein EngA [Streptococcus pneumoniae CCRI 1974M2] gi\|242244928, gi... - gi\|242244928\|ref\|ZP_04799365.1\| GTP-binding protein EngA [Streptococcus pneumoniae TCH8431/19A], gi\|...	6.0E-59	[88..505]	[6..430]
DER_BACSU - GTPase Der OS=Bacillus subtilis (strain 168) GN=der PE=1 SV=1 ENGA_BACSU, DER_... - GTP-binding protein engA OS=Bacillus subtilis GN=engA PE=1 SV=1, GTPase Der OS=Bacillus subtilis GN=... gi\|221319445 - gi\|221319445\|ref\|ZP_03600739.1\| GTP-binding protein EngA [Bacillus subtilis subsp. subtilis str. JH6... gi\|221323721 - gi\|221323721\|ref\|ZP_03605015.1\| GTP-binding protein EngA [Bacillus subtilis subsp. subtilis str. SMY... gi\|221314523 - gi\|221314523\|ref\|ZP_03596328.1\| GTP-binding protein EngA [Bacillus subtilis subsp. subtilis str. NCI...	2.0E-58	[88..505]	[6..430]
gi\|209763420, gi... - gi\|7450586\|pir\|\|F65027 probable GTPase/GTP-binding protein b2511 - Escherichia coli (strain K-12), g... gi\|1788858, gi\|1... - gb\|AAC75564.1\| putative GTP-binding factor; GTP-binding protein, essential for cell growth [Escheric... gi\|15832627, gi\|... - gi\|15832627\|ref\|NP_311400.1\| GTP-binding protein EngA [Escherichia coli O157:H7], gi\|13362843\|dbj\|BA... gi\|15832627, gi\|... - gi\|15832627\|ref\|NP_311400.1\| GTP-binding protein EngA [Escherichia coli O157:H7 str. Sakai], gi\|1336... gi\|12516902, gi\|... - gi\|15803034\|ref\|NP_289064.1\| GTP-binding protein EngA [Escherichia coli O157:H7 EDL933], gi\|12516902...	3.0E-58	[88..468]	[18..385]
gi\|213609480 - gi\|213609480\|ref\|ZP_03369306.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serova... gi\|213425335 - gi\|213425335\|ref\|ZP_03358085.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serova... ENGA_SALTI - GTP-binding protein engA OS=Salmonella typhi GN=engA PE=3 SV=1 gi\|214000627 - gi\|214000627\|ref\|ZP_03411362.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serova... gi\|213861384 - gi\|213861384\|ref\|ZP_03385854.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serova... gi\|213161952 - gi\|213161952\|ref\|ZP_03347662.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serova... gi\|16761434 - gi\|16761434\|ref\|NP_457051.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serovar T... DER_SALTI - GTPase Der OS=Salmonella typhi GN=der PE=3 SV=1 gi\|29136494, gi\|... - gi\|29140869\|ref\|NP_804211.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serovar T...	1.0E-57	[88..468]	[5..372]
gi\|238912639 - gi\|238912639\|ref\|ZP_04656476.1\| GTP-binding protein EngA [Salmonella enterica subsp. enterica serova... lcl\|NC_016856.1_... - [gene=engA] [protein=GTP-binding protein EngA] [protein_id=YP_005238616.1] [location=complement(2703... ENGA_SALTY, DER_... - GTP-binding protein engA OS=Salmonella typhimurium GN=engA PE=1 SV=2, GTPase Der OS=Salmonella typhi... DER_SALPK - GTPase Der OS=Salmonella paratyphi A (strain AKU_12601) GN=der PE=3 SV=1 gi\|197264629, gi... - gi\|197264629\|ref\|ZP_03164703.1\| ribosome-associated GTPase EngA [Salmonella enterica subsp. enterica... gi\|205325405, gi... - gi\|205325405\|gb\|EDZ13244.1\| ribosome-associated GTPase EngA [Salmonella enterica subsp. enterica ser... ENGA_SALTY - GTP-binding protein engA OS=Salmonella typhimurium GN=engA PE=3 SV=2 DER_SALNS - GTPase Der OS=Salmonella newport (strain SL254) GN=der PE=3 SV=1 gi\|195630729, gi... - gi\|195630729\|gb\|EDX49321.1\| ribosome-associated GTPase EngA [Salmonella enterica subsp. enterica ser... gi\|205349650, gi... - gi\|205349650\|gb\|EDZ36281.1\| ribosome-associated GTPase EngA [Salmonella enterica subsp. enterica ser... gi\|167991827, gi... - gi\|205329876\|gb\|EDZ16640.1\| ribosome-associated GTPase EngA [Salmonella enterica subsp. enterica ser... DER_SALPA - GTPase Der OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=der PE=3 SV=1 ENGA_SALPA, DER_... - GTP-binding protein engA OS=Salmonella paratyphi A GN=engA PE=3 SV=1, GTPase Der OS=Salmonella parat... DER_SALTY - GTPase Der OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=der PE=1 SV=2	1.0E-57	[88..468]	[5..372]
DER_STRPC - GTPase Der OS=Streptococcus pyogenes serotype M12 (strain MGAS9429) GN=der PE=3 SV=1 gi\|13621599, gi\|... - gi\|15674498\|ref\|NP_268672.1\| GTP-binding protein EngA [Streptococcus pyogenes M1 GAS], gi\|13621599\|g... ENGA_STRPY - (P64064) GTP-binding protein engA DER_STRPB - GTPase Der OS=Streptococcus pyogenes serotype M12 (strain MGAS2096) GN=der PE=3 SV=1 DER_STRP8, ENGA_... - GTP-binding protein engA OS=Streptococcus pyogenes serotype M18 GN=engA PE=3 SV=1, GTPase Der OS=Str... DER_STRPZ - GTPase Der OS=Streptococcus pyogenes serotype M49 (strain NZ131) GN=der PE=3 SV=1 DER_STRP8 - GTPase Der OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=der PE=3 SV=1 DER_STRP6 - GTPase Der OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) GN=der PE=3 SV=1 DER_STRP1 - GTPase Der OS=Streptococcus pyogenes serotype M1 GN=der PE=3 SV=1 gi\|56808746 - gi\|56808746\|ref\|ZP_00366464.1\| COG1160: Predicted GTPases [Streptococcus pyogenes M49 591] gi\|71910101, gi\|... - gi\|71910101\|ref\|YP_281651.1\| GTP-binding protein EngA [Streptococcus pyogenes MGAS5005], gi\|71852883... ENGA_STRP6, DER_... - GTP-binding protein engA OS=Streptococcus pyogenes serotype M6 GN=engA PE=3 SV=1, GTPase Der OS=Stre...	1.0E-57	[88..505]	[6..430]
DER_CLOPE, ENGA_... - GTP-binding protein engA OS=Clostridium perfringens GN=engA PE=3 SV=1, GTPase Der OS=Clostridium per... DER_CLOP1 - GTPase Der OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 82... DER_CLOPS - GTPase Der OS=Clostridium perfringens (strain SM101 / Type A) GN=der PE=3 SV=1 gi\|168217042, gi... - gi\|182380862\|gb\|EDT78341.1\| putative GTP-binding protein Era [Clostridium perfringens NCTC 8239], gi... DER_CLOPE - GTPase Der OS=Clostridium perfringens (strain 13 / Type A) GN=der PE=3 SV=1 gi\|169299237, gi... - gi\|169342731\|ref\|ZP_02863772.1\| putative GTP-binding protein Era [Clostridium perfringens C str. JGS... gi\|177908885, gi... - gi\|182625851\|ref\|ZP_02953617.1\| putative GTP-binding protein Era [Clostridium perfringens D str. JGS... gi\|170661368, gi... - gi\|170661368\|gb\|EDT14051.1\| putative GTP-binding protein Era [Clostridium perfringens E str. JGS1987... gi\|170711316, gi... - gi\|170711316\|gb\|EDT23498.1\| putative GTP-binding protein Era [Clostridium perfringens B str. ATCC 36... gi\|170714259, gi... - gi\|170714259\|gb\|EDT26441.1\| putative GTP-binding protein Era [Clostridium perfringens CPE str. F4969...	4.0E-57	[88..507]	[6..433]

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Predicted Domain #1

Region A:
Residues: [1-83]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVRKRQSRR TSTKLKEGIK KKASAHRKKE KKMAKKDVTW RSRSKKDPGI PSNFPYKAKI  60
   61 LEEIEAKKMK DLEERELAKQ QRL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.427	a.2.7	tRNA-binding arm
View	Download	0.638	d.56.1	GroEL-intermediate domain like
View	Download	0.453	d.204.1	Ribosome binding protein Y (YfiA homologue)
View	Download	0.423	d.56.1	GroEL-intermediate domain like
View	Download	0.416	a.8.2	Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View	Download	0.408	a.2.11	Fe,Mn superoxide dismutase (SOD), N-terminal domain
View	Download	0.407	a.60.1	SAM/Pointed domain
View	Download	0.390	d.50.1	dsRNA-binding domain-like
View	Download	0.378	a.24.17	Group V grass pollen allergen
View	Download	0.373	a.23.1	HSC20 (HSCB), C-terminal oligomerisation domain
View	Download	0.345	d.56.1	GroEL-intermediate domain like
View	Download	0.344	a.2.11	Fe,Mn superoxide dismutase (SOD), N-terminal domain
View	Download	0.334	f.14.1	Voltage-gated potassium channels
View	Download	0.324	b.55.1	PH domain-like
View	Download	0.309	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.301	a.118.8	TPR-like
View	Download	0.301	a.156.1	S13-like H2TH domain
View	Download	0.285	d.74.5	Hypothetical protein Yml108w
View	Download	0.283	a.134.1	Fungal elicitin
View	Download	0.282	f.16.1	Gated mechanosensitive channel
View	Download	0.281	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.273	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.266	a.7.7	BAG domain
View	Download	0.244	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.242	d.204.1	Ribosome binding protein Y (YfiA homologue)
View	Download	0.238	a.74.1	Cyclin-like
View	Download	0.232	a.74.1	Cyclin-like
View	Download	0.231	a.46.1	Methionine synthase domain
View	Download	0.230	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.228	a.2.3	Chaperone J-domain
View	Download	0.227	a.2.1	GreA transcript cleavage protein, N-terminal domain
View	Download	0.224	a.2.11	Fe,Mn superoxide dismutase (SOD), N-terminal domain
View	Download	0.223	d.52.7	Ribosome-binding factor A, RbfA
View	Download	0.222	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.220	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.217	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.217	a.156.1	S13-like H2TH domain
View	Download	0.215	a.2.11	Fe,Mn superoxide dismutase (SOD), N-terminal domain
View	Download	0.215	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.214	d.201.1	SRP19
View	Download	0.213	a.50.1	Anaphylotoxins (complement system)
View	Download	0.212	a.2.11	Fe,Mn superoxide dismutase (SOD), N-terminal domain
View	Download	0.210	a.25.1	Ferritin-like
View	Download	0.209	a.60.1	SAM/Pointed domain
View	Download	0.208	a.29.4	RecG, N-terminal domain
View	Download	0.206	d.52.1	Alpha-lytic protease prodomain

Predicted Domain #2

Region A:
Residues: [84-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EARKAAKEQG VDAMDEDMIE DDENGLAALV ESAQQAAAEY EGTPSNDADV RDDELDVIDY  60
   61 NIDFYGEDVE GESELEKSRK AYDKIFKSVI DASDVILYVL DARDPESTRS RKVEEAVLQS 120
  121 QGKRLILILN KVDLIPPHVL EQWLNYLKSS FPTIPLRASS GAVNGTSFNR KLSQTTTASA 180
  181 LLESL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	3ranA_
Description:	Ran
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [269-520]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTYSNNSNLK RSIVVGVIGY PNVGKSSVIN ALLARRGGQS KACPVGNEAG VTTSLREIKI  60
   61 DNKLKILDSP GICFPSENKK RSKVEHEAEL ALLNALPAKH IVDPYPAVLM LVKRLAKSDE 120
  121 MTESFKKLYE IPPIPANDAD TFTKHFLIHV ARKRGRLGKG GIPNLASAGL SVLNDWRDGK 180
  181 ILGWVLPNTS AAASQQDKQN LSTINTGTKQ APIAANESTI VSEWSKEFDL DGLFSSLDKA 240
  241 IDASKDQDTM ME

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.69897
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits