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View Structure Prediction Details

Protein: NSE1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 336 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NSE1_YEAST.

Description E-value Query
Range
Subject
Range
NSE1 - Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth...
gi|151941175 - gi|151941175|gb|EDN59553.1| essential subunit of the Mms21-Smc5-Smc6 complex [Saccharomyces cerevisi...
gi|190406048 - gi|190406048|gb|EDV09315.1| non-structural maintenance of chromosome element 1 [Saccharomyces cerevi...
NSE1_YEAST - Non-structural maintenance of chromosomes element 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 ...
0.0 [1..336] [1..336]
NSE1_MOUSE - Non-structural maintenance of chromosomes element 1 homolog OS=Mus musculus GN=Nsmce1 PE=1 SV=1
3.0E-51 [115..289] [58..207]
gi|6841324 - gi|6841324|gb|AAF29015.1|AF161455_1 HSPC337 [Homo sapiens]
4.0E-25 [115..228] [81..170]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVHEEQVSA PVTGDATAKY LLQYILSARG ICHENALILA LMRLETDAST LNTEWSIQQW  60
   61 VDKLNDYINA INVKLNLLGY KIIRINHGIG RNAVTLKAKQ NFESFED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.733 d.8.1 Urease, gamma-subunit
View Download 0.691 a.24.17 Group V grass pollen allergen
View Download 0.715 a.7.6 Ribosomal protein S20
View Download 0.798 a.29.4 RecG, N-terminal domain
View Download 0.676 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.669 a.141.1 Frizzled cystein-rich domain
View Download 0.655 a.74.1 Cyclin-like
View Download 0.649 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.638 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.618 a.74.1 Cyclin-like
View Download 0.609 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.592 a.141.1 Frizzled cystein-rich domain
View Download 0.581 a.4.5 "Winged helix" DNA-binding domain
View Download 0.570 a.7.6 Ribosomal protein S20
View Download 0.560 a.4.5 "Winged helix" DNA-binding domain
View Download 0.541 d.95.2 Homing endonucleases
View Download 0.538 a.24.9 alpha-catenin/vinculin
View Download 0.529 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.520 d.95.2 Homing endonucleases
View Download 0.514 a.71.2 Helical domain of Sec23/24
View Download 0.508 a.24.4 Hemerythrin
View Download 0.500 d.74.5 Hypothetical protein Yml108w
View Download 0.498 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.483 b.60.1 Lipocalins
View Download 0.481 a.118.1 ARM repeat
View Download 0.468 a.39.1 EF-hand
View Download 0.467 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.466 d.58.7 RNA-binding domain, RBD
View Download 0.465 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.464 a.29.4 RecG, N-terminal domain
View Download 0.463 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.461 a.141.1 Frizzled cystein-rich domain
View Download 0.459 a.4.5 "Winged helix" DNA-binding domain
View Download 0.454 a.61.1 Retroviral matrix proteins
View Download 0.447 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.442 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.440 d.45.1 ClpS-like
View Download 0.426 a.4.5 "Winged helix" DNA-binding domain
View Download 0.411 d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.406 a.74.1 Cyclin-like
View Download 0.405 d.17.1 Cystatin/monellin
View Download 0.402 a.4.5 "Winged helix" DNA-binding domain
View Download 0.402 d.95.2 Homing endonucleases
View Download 0.397 a.5.4 Elongation factor TFIIS domain 2
View Download 0.396 c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.395 d.58.5 GlnB-like
View Download 0.394 a.4.5 "Winged helix" DNA-binding domain
View Download 0.392 a.74.1 Cyclin-like
View Download 0.390 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.383 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.381 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.376 a.5.4 Elongation factor TFIIS domain 2
View Download 0.376 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.371 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.370 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.370 d.169.1 C-type lectin-like
View Download 0.368 d.58.7 RNA-binding domain, RBD
View Download 0.367 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.363 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.361 b.55.1 PH domain-like
View Download 0.357 a.24.3 Cytochromes
View Download 0.354 a.5.4 Elongation factor TFIIS domain 2
View Download 0.353 b.115.1 Fucose-binding lectin II (PA-IIL)
View Download 0.343 a.5.4 Elongation factor TFIIS domain 2
View Download 0.342 d.8.1 Urease, gamma-subunit
View Download 0.331 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.331 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.330 a.4.5 "Winged helix" DNA-binding domain
View Download 0.326 d.205.1 GTP cyclohydrolase I feedback regulatory protein, GFRP
View Download 0.325 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.325 d.131.1 DNA clamp
View Download 0.324 a.24.4 Hemerythrin
View Download 0.324 a.4.5 "Winged helix" DNA-binding domain
View Download 0.323 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.321 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.320 d.68.3 SirA-like
View Download 0.320 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.318 d.45.1 ClpS-like
View Download 0.317 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.313 d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.310 d.169.1 C-type lectin-like
View Download 0.307 a.24.17 Group V grass pollen allergen
View Download 0.306 a.40.1 Calponin-homology domain, CH-domain
View Download 0.306 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.301 b.40.2 Bacterial enterotoxins
View Download 0.301 d.8.1 Urease, gamma-subunit
View Download 0.299 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.299 a.101.1 Uteroglobin-like
View Download 0.298 a.39.1 EF-hand
View Download 0.295 c.78.2 Aspartate/glutamate racemase
View Download 0.294 a.77.1 DEATH domain
View Download 0.292 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.291 a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.288 c.114.1 YchN-like
View Download 0.287 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.286 a.63.1 Apolipophorin-III
View Download 0.286 d.169.1 C-type lectin-like
View Download 0.282 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.281 a.4.5 "Winged helix" DNA-binding domain
View Download 0.278 d.95.2 Homing endonucleases
View Download 0.278 d.205.1 GTP cyclohydrolase I feedback regulatory protein, GFRP
View Download 0.278 a.156.1 S13-like H2TH domain
View Download 0.276 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.276 a.40.1 Calponin-homology domain, CH-domain
View Download 0.276 a.112.1 Description not found.
View Download 0.274 f.17.1 F1F0 ATP synthase subunit C
View Download 0.272 a.29.2 Bromodomain
View Download 0.269 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.266 a.144.1 PABC (PABP) domain
View Download 0.264 d.32.1 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
View Download 0.263 a.47.2 t-snare proteins
View Download 0.263 a.1.1 Globin-like
View Download 0.262 a.74.1 Cyclin-like
View Download 0.261 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.261 a.59.1 PAH2 domain
View Download 0.261 d.58.7 RNA-binding domain, RBD
View Download 0.259 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.258 a.19.1 Fertilization protein
View Download 0.258 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.257 a.74.1 Cyclin-like
View Download 0.257 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.254 a.74.1 Cyclin-like
View Download 0.254 a.64.1 Saposin
View Download 0.254 g.53.1 TAZ domain
View Download 0.251 a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.250 d.58.49 YajQ-like
View Download 0.249 a.77.1 DEATH domain
View Download 0.249 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.249 a.2.3 Chaperone J-domain
View Download 0.248 a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.248 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.247 a.1.1 Globin-like
View Download 0.245 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.245 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.245 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.243 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.243 a.29.2 Bromodomain
View Download 0.243 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.243 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.239 a.46.1 Methionine synthase domain
View Download 0.236 c.9.1 Barstar (barnase inhibitor)
View Download 0.236 d.13.1 HIT-like
View Download 0.234 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.233 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.233 a.130.1 Chorismate mutase II
View Download 0.228 c.3.1 FAD/NAD(P)-binding domain
View Download 0.227 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.226 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.226 d.79.1 YjgF-like
View Download 0.225 c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.223 c.47.1 Thioredoxin-like
View Download 0.223 a.118.8 TPR-like
View Download 0.219 a.1.1 Globin-like
View Download 0.216 c.95.1 Thiolase-like
View Download 0.215 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.215 a.4.5 "Winged helix" DNA-binding domain
View Download 0.214 a.61.1 Retroviral matrix proteins
View Download 0.214 d.24.1 Pili subunits
View Download 0.212 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.212 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.205 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.205 d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase
View Download 0.204 d.95.2 Homing endonucleases
View Download 0.202 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.202 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.201 a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #2
Region A:
Residues: [108-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTAIRAHNND YAVLQSIVLP ESNRFFVYVN LASTEETKLA TRFNQNEIEF MKWAIEQFMI  60
   61 SGETIVEGPA LETSIIVKEV NRILVAATGD SNLAKWR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.653 0.933 DNA repair b.40.4 Nucleic acid-binding proteins
View Download 0.507 0.022 cell proliferation b.1.2 Fibronectin type III
View Download 0.495 0.000 DNA repair b.40.2 Bacterial enterotoxins
View Download 0.429 0.000 DNA repair d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.562 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.429 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.419 N/A N/A b.1.18 E set domains
View Download 0.368 N/A N/A b.61.1 Avidin/streptavidin
View Download 0.367 N/A N/A b.71.1 Glycosyl hydrolase domain
View Download 0.345 N/A N/A a.20.1 PGBD-like
View Download 0.304 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.295 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.289 N/A N/A a.40.1 Calponin-homology domain, CH-domain
View Download 0.279 N/A N/A d.18.1 ssDNA-binding transcriptional regulator domain
View Download 0.271 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.268 N/A N/A d.15.5 Staphylokinase/streptokinase
View Download 0.268 N/A N/A a.3.1 Cytochrome c
View Download 0.257 N/A N/A c.55.5 MTH1175-like
View Download 0.235 N/A N/A c.47.1 Thioredoxin-like
View Download 0.223 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.222 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.219 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.211 N/A N/A a.28.1 ACP-like
View Download 0.205 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.202 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #3
Region A:
Residues: [205-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFSTFTVGST NLFQFQELTA TDIEDLLLRL CELKWFYRTQ EGKFGIDLRC IAELEEYLTS  60
   61 MYNLNTCQNC HKLAIQGVRC GNESCREENE ETGENSLSQI WHVDCFKHYI THVSKNCDRC 120
  121 GSSLITEGVY VI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.346 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.296 a.24.9 alpha-catenin/vinculin
View Download 0.430 a.133.1 Phospholipase A2, PLA2
View Download 0.388 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.281 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.276 f.14.1 Voltage-gated potassium channels
View Download 0.267 d.110.4 SNARE-like
View Download 0.235 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.231 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.225 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.225 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.211 a.7.1 Spectrin repeat
View Download 0.208 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.205 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.205 f.14.1 Voltage-gated potassium channels


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