YRC Public Data Repository - Protein Structure Prediction

Protein:	LAC1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAC1_YEAST.

Description	E-value	Query Range	Subject Range
gi\|207343442 - gi\|207343442\|gb\|EDZ70899.1\| YKL008Cp-like protein [Saccharomyces cerevisiae AWRI1631] LAC1_YEAST - Sphingosine N-acyltransferase LAC1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAC1 ... LAC1_YEAS7 - Sphingosine N-acyltransferase LAC1 OS=Saccharomyces cerevisiae (strain YJM789) GN=LAC1 PE=3 SV=1 LAC1 - Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydro...	0.0	[1..389]	[1..389]
mug83 - sphingosine N-acyltransferase Lac1 LAC1_SCHPO - Sphingosine N-acyltransferase lac1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lac1 PE...	0.0	[11..384]	[3..357]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	6.0E-92	[44..384]	[1..330]
gi\|148227942, gi... - gi\|83405982\|gb\|AAI10704.1\| LOC398230 protein [Xenopus laevis], gi\|148227942\|ref\|NP_001082108.1\| Tram...	2.0E-91	[61..385]	[4..321]
gi\|13936277 - gi\|13936277\|gb\|AAK40297.1\| Tram1 [Danio rerio]	4.0E-85	[61..385]	[4..322]
TRAM1_CANLF - Translocating chain-associated membrane protein 1 OS=Canis lupus familiaris GN=TRAM1 PE=1 SV=2	7.0E-83	[61..385]	[4..322]
TRAM1_MOUSE - Translocating chain-associated membrane protein 1 OS=Mus musculus GN=Tram1 PE=1 SV=3	1.0E-82	[61..385]	[4..322]
gi\|123984537, gi... - gi\|60655235\|gb\|AAX32181.1\| translocation associated membrane protein 1 [synthetic construct], gi\|123... TRAM1 - translocation associated membrane protein 1	6.0E-82	[61..385]	[4..322]

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Predicted Domain #1

Region A:
Residues: [1-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTIKPSPSN NNLKVRSRPR RKSSIGKIDL GDTVPSLGTM FETKESKTAA KRRMQRLSEA  60
   61 TKNDSDLVKK IWFSFREISY RHAWIAPLMI LIAVYSAYFT SGNTTKTNVL HRFVAVSYQI 120
  121 GDTNAYGKGI NDLCFVFYYM IFFTFLREFL MDVVIRPFAI RLHV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [165-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSKHRIKRIM EQMYAIFYTG VSGPFGIYCM YHSDLWFFNT KAMYRTYPDF TNPFLFKVFY  60
   61 LGQAAFWAQQ ACILVLQLEK PRKDHNELTF HHIVTLLLIW SSYVFHFTKM GLPIYITMDV 120
  121 SDFLLSFSKT LNYLDSGLAF FSFAIFVVAW IYLRHYINLK ILWSVLTQFR TEGNYVLNFA 180
  181 TQQYKCWISL PIVFVLIGAL QLVNLYWLFL IFRVLYRILW RGILKDDRSD SESDEESDES 240
  241 STTPTDSTPT KKDI

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	101.173925
Match:	PF03798
Description:	Longevity-assurance protein (LAG1)

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [198-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLWFFNTKAM YRTYPDFTNP FLFKVFYLGQ AAFWAQQACI LVLQLEKPRK DHNELTFHHI  60
   61 VTLLLIWSSY VFHFTKMGLP IYITMDVSDF LLSFSKTLNY LDSGLAFFSF AIFVVAWIYL 120
  121 RHYINLKILW SVLTQFRTEG NYVLNFATQQ YKCWISLPIV FVLIGALQLV NLYWLFLIFR 180
  181 VLYRILWRGI LKDDRSDSES DEESDESSTT PTDSTPTKKD I

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits