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View Structure Prediction Details

Protein: IMDH4_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 524 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMDH4_YEAST.

Description E-value Query
Range		 Subject
Range
IMD4 - Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-...
IMDH4_YEAST - Inosine-5'-monophosphate dehydrogenase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
 0.0 [1..524] [1..524]
IMDH_CANAL - Inosine-5'-monophosphate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IMH3 P...
IMDH_CANAX - Inosine-5'-monophosphate dehydrogenase OS=Candida albicans GN=IMH3 PE=2 SV=1
 0.0 [8..524] [5..521]
IMPDH1 - IMP (inosine 5'-monophosphate) dehydrogenase 1
 0.0 [18..523] [12..514]
gua1 - IMP dehydrogenase Gua1
IMDH_SCHPO - Inosine-5'-monophosphate dehydrogenase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gua...
 0.0 [3..523] [2..524]
IMDH2_CRIGR - Inosine-5'-monophosphate dehydrogenase 2 OS=Cricetulus griseus GN=IMPDH2 PE=1 SV=1
 0.0 [17..523] [11..514]
IMDH2_MOUSE - Inosine-5'-monophosphate dehydrogenase 2 OS=Mus musculus GN=Impdh2 PE=1 SV=2
 0.0 [17..523] [11..514]

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Predicted Domain #1
Region A:
Residues: [1-524] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAPLDYKK ALEHLKTYSS KDGLSVQELM DSTTRGGLTY NDFLVLPGLV NFPSSAVSLQ  60
   61 TKLTKKITLN TPFVSSPMDT VTEADMAIYM ALLGGIGFIH HNCTPKEQAS MVKKVKMFEN 120
  121 GFINSPIVIS PTTTVGEVKV MKRKFGFSGF PVTEDGKCPG KLVGLVTSRD IQFLEDDSLV 180
  181 VSEVMTKNPV TGIKGITLKE GNEILKQTKK GKLLIVDDNG NLVSMLSRAD LMKNQNYPLA 240
  241 SKSATTKQLL CGAAIGTIEA DKERLRLLVE AGLDVVILDS SQGNSVFQLN MIKWIKETFP 300
  301 DLEIIAGNVA TREQAANLIA AGADGLRIGM GSGSICITQE VMACGRPQGT AVYNVCQFAN 360
  361 QFGVPCMADG GVQNIGHITK ALALGSSTVM MGGMLAGTTE SPGEYFYKDG KRLKAYRGMG 420
  421 SIDAMQKTGN KGNASTSRYF SESDSVLVAQ GVSGAVVDKG SIKKFIPYLY NGLQHSCQDI 480
  481 GCESLTSLKE NVQNGEVRFE FRTASAQLEG GVHNLHSYEK RLYN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10146.0
Match: 1b3oA_
Description: Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
IMP dehydrogenase activity 2.02048863053452 bayes_pls_golite062009
binding 0.964202692685807 bayes_pls_golite062009
transporter activity 0.961062314616209 bayes_pls_golite062009
transmembrane transporter activity 0.807029018941177 bayes_pls_golite062009
substrate-specific transporter activity 0.640881170978843 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.525366315833255 bayes_pls_golite062009
ion transmembrane transporter activity 0.440262824681055 bayes_pls_golite062009
protein binding 0.22179604283012 bayes_pls_golite062009
catalytic activity 0.181756622780318 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.0973526732376297 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle