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View Structure Prediction Details

Protein: HSP42_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 375 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSP42_YEAST.

Description E-value Query
Range		 Subject
Range
HSP42 - Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress...
gi|207346637 - gi|207346637|gb|EDZ73077.1| YDR171Wp-like protein [Saccharomyces cerevisiae AWRI1631]
HSP42_YEAST - Heat shock protein 42 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSP42 PE=1 SV=1
gi|190404874 - gi|190404874|gb|EDV08141.1| heat shock protein 42 [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..375] [1..375]
HS22C_PETHY - Small heat shock protein, chloroplastic OS=Petunia hybrida GN=HSP22 PE=2 SV=1
 2.0E-46 [138..345] [42..234]
gi|4028567, gi|2... - gi|4028567|gb|AAC96314.1| heat shock protein HSP26 [Triticum aestivum], gi|220675835|emb|CAM12753.1|...
 2.0E-45 [144..345] [36..231]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 5.0E-45 [138..354] [39..240]
gi|8671873 - gi|8671873|gb|AAF78436.1|AC018748_15 Contains similarity to 17.6 KD class I heat shock protein from ...
 8.0E-45 [193..356] [245..402]
HS21C_SOLLC - Small heat shock protein, chloroplastic OS=Solanum lycopersicum GN=HSP21 PE=2 SV=1
 2.0E-44 [141..354] [38..235]
HSP13_SOYBN - 17.5 kDa class I heat shock protein OS=Glycine max GN=HSP17.5-M PE=3 SV=1
 8.0E-44 [195..356] [1..152]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 1.0E-43 [195..356] [1..153]

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Predicted Domain #1
Region A:
Residues: [1-188] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFYQPSLSL YDVLNALSNQ TGQRGQQGYP RQPQRPQRYH PHYGQVHVGG HHPRHHPLYS  60
   61 RYNGVPNTYY YQFPGQAYYY SPEYGYDDED GEEEDQDEDM VGDSGTTRQE DGGEDSNSRR 120
  121 YPSYYHCNTA RNNRTNQQAN SLNDLLTALI GVPPYEGTEP EIEANTEQEG EKGEEKDKKD 180
  181 KSEAPKEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [189-375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGETNKEKPL NQLEESSRPP LAKKSSSFAH LQAPSPIPDP LQVSKPETRM DLPFSPEVNV  60
   61 YDTEDTYVVV LALPGANSRA FHIDYHPSSH EMLIKGKIED RVGIDEKFLK ITELKYGAFE 120
  121 RTVKFPVLPR IKDEEIKATY NNGLLQIKVP KIVNDTEKPK PKKRIAIEEI PDEELEFEEN 180
  181 PNPTVEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.30103
Match: 1gmeA_
Description: Small heat shock protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 2.66693334592032 bayes_pls_golite062009
binding 1.39874024053677 bayes_pls_golite062009
protein binding 0.950651976327201 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle