YRC Public Data Repository - Protein Structure Prediction

Protein:	HMCS_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	491 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMCS_YEAST.

Description	E-value	Query Range	Subject Range
gi\|151946038 - gi\|151946038\|gb\|EDN64269.1\| 3-hydroxy-3-methylglutaryl coenzyme A synthase [Saccharomyces cerevisiae... gi\|190408122 - gi\|190408122\|gb\|EDV11387.1\| 3-hydroxy-3-methylglutaryl coenzyme A synthase [Saccharomyces cerevisiae... HMCS_YEAST - Hydroxymethylglutaryl-CoA synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG13... ERG13 - 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-Co...	0.0	[1..491]	[1..491]
HMCS2_RAT - Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Rattus norvegicus GN=Hmgcs2 PE=1 SV=1	0.0	[13..490]	[25..506]
HMCS2_MOUSE - Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus musculus GN=Hmgcs2 PE=1 SV=2	0.0	[13..489]	[25..505]
HMCS2_PIG - Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Sus scrofa GN=HMGCS2 PE=2 SV=1	0.0	[12..489]	[24..505]
HMGCS2 - 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.0	[13..490]	[25..506]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[33..489]	[1..468]

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Predicted Domain #1

Region A:
Residues: [1-374]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSTKLCWC GIKGRLRPQK QQQLHNTNLQ MTELKKQKTA EQKTRPQNVG IKGIQIYIPT  60
   61 QCVNQSELEK FDGVSQGKYT IGLGQTNMSF VNDREDIYSM SLTVLSKLIK SYNIDTNKIG 120
  121 RLEVGTETLI DKSKSVKSVL MQLFGENTDV EGIDTLNACY GGTNALFNSL NWIESNAWDG 180
  181 RDAIVVCGDI AIYDKGAARP TGGAGTVAMW IGPDAPIVFD SVRASYMEHA YDFYKPDFTS 240
  241 EYPYVDGHFS LTCYVKALDQ VYKSYSKKAI SKGLVSDPAG SDALNVLKYF DYNVFHVPTC 300
  301 KLVTKSYGRL LYNDFRANPQ LFPEVDAELA TRDYDESLTD KNIEKTFVNV AKPFHKERVA 360
  361 QSLIVPTNTG NMYT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.0
Match:	1cgkA_
Description:	Chalcone synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [375-491]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASVYAAFASL LNYVGSDDLQ GKRVGLFSYG SGLAASLYSC KIVGDVQHII KELDITNKLA  60
   61 KRITETPKDY EAAIELRENA HLKKNFKPQG SIEHLQSGVY YLTNIDDKFR RSYDVKK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	7.958607
Match:	PF01154
Description:	Hydroxymethylglutaryl-coenzyme A synthase N terminal

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits