YRC Public Data Repository - Protein Structure Prediction

Protein:	CKS1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	150 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CKS1_YEAST.

Description	E-value	Query Range	Subject Range
CKS1_YEAST - Cyclin-dependent kinases regulatory subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... CKS1 - Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase tar... gi\|151946525 - gi\|151946525\|gb\|EDN64747.1\| cyclin-dependent protein kinase subunit [Saccharomyces cerevisiae YJM789...	2.0E-49	[1..150]	[1..150]
gi\|157833583, gi... - gi\|157833583\|pdb\|1PUC\|A Chain A, P13suc1 In A Strand-Exchanged Dimer, gi\|1421400\|pdb\|1PUC\| Chain ,...	1.0E-35	[11..107]	[7..103]
suc1 - cyclin-dependent protein kinase regulatory subunit Suc1 CKS1_SCHPO - Cyclin-dependent kinases regulatory subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...	2.0E-35	[11..107]	[8..104]
gi\|3108171, gi\|3... - gi\|3108171\|gb\|AAC15772.1\| Cdc2 binding protein Suc1 [Pneumocystis carinii f. sp. carinii], gi\|310816...	1.0E-32	[11..111]	[11..111]
CE22913 - status:Partially_confirmed UniProt:Q95XM4 protein_id:AAK73928.1	2.0E-30	[26..129]	[2..98]
CKS1_LEIME - Cyclin-dependent kinases regulatory subunit OS=Leishmania mexicana PE=3 SV=1	1.0E-27	[21..104]	[24..98]
CKS2_ARATH - Cyclin-dependent kinases regulatory subunit 2 OS=Arabidopsis thaliana GN=CKS2 PE=3 SV=1	2.0E-27	[27..115]	[3..82]

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Predicted Domain #1

Region A:
Residues: [1-150]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYHHYHAFQG RKLTDQERAR VLEFQDSIHY SPRYSDDNYE YRHVMLPKAM LKVIPSDYFN  60
   61 SEVGTLRILT EDEWRGLGIT QSLGWEHYEC HAPEPHILLF KRPLNYEAEL RAATAAAQQQ 120
  121 QQQQQQQQQQ QQQHQTQSIS NDMQVPPQIS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.313	0.721	protein kinase activator activity	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.325	0.018	protein kinase activator activity	d.110.4	SNARE-like
View	Download	0.233	0.010	protein kinase activator activity	d.110.2	GAF domain-like
View	Download	0.292	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.243	N/A	N/A	d.87.1	FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View	Download	0.207	N/A	N/A	d.109.1	Actin depolymerizing proteins
View	Download	0.203	N/A	N/A	d.110.2	GAF domain-like

Predicted functions:

Term	Confidence	Notes
cyclin-dependent protein kinase regulator activity	3.97841828100668	bayes_pls_golite062009
binding	2.18113207610794	bayes_pls_golite062009
protein binding	1.97943309243131	bayes_pls_golite062009
protein kinase regulator activity	1.37860707665544	bayes_pls_golite062009
kinase regulator activity	1.32978090173102	bayes_pls_golite062009
protein kinase binding	0.944579171364175	bayes_pls_golite062009
kinase binding	0.867010292327918	bayes_pls_golite062009
enzyme binding	0.54410658997703	bayes_pls_golite062009
enzyme regulator activity	0.334428481657021	bayes_pls_golite062009
small conjugating protein binding	0.32298430897304	bayes_pls_golite062009
ubiquitin binding	0.2354005843111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: