YRC Public Data Repository - Protein Structure Prediction

Protein:	APM2_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	605 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APM2_YEAST.

Description	E-value	Query Range	Subject Range
APM2_YEAST - Adaptin medium chain homolog APM2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APM2 P... APM2 - Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein...	0.0	[1..605]	[1..605]
AP50_DICDI, AP2M... - (P54672) Clathrin coat assembly protein AP50 (Clathrin coat associated protein AP50) (Plasma membran...	8.0E-99	[1..543]	[1..436]
gi\|123987359, gi... - gi\|60655697\|gb\|AAX32412.1\| adaptor-related protein complex 2 mu 1 subunit [synthetic construct], gi\|... gi\|109042889, gi... - gi\|109042892\|ref\|XP_001102690.1\| PREDICTED: similar to adaptor-related protein complex 2, mu 1 subun... AP2M1 - adaptor-related protein complex 2, mu 1 subunit ENSCJAT00000025335 - null AP2M1_MOUSE - AP-2 complex subunit mu OS=Mus musculus GN=Ap2m1 PE=1 SV=1 gi\|114590717, gi... - gi\|114590719\|ref\|XP_001143649.1\| PREDICTED: adaptor-related protein complex 2, mu 1 subunit isoform ... gi\|149731154 - gi\|149731154\|ref\|XP_001497196.1\| PREDICTED: adaptor-related protein complex 2, mu 1 subunit isoform ... tr\|G1SM15\|G1SM15... - pep:novel chromosome:oryCun2:14:81523950:81532418:-1 gene:ENSOCUG00000004556 transcript:ENSOCUT00000... AP2M1_RAT - AP-2 complex subunit mu OS=Rattus norvegicus GN=Ap2m1 PE=1 SV=1 AP2M1_BOVIN - AP-2 complex subunit mu OS=Bos taurus GN=AP2M1 PE=2 SV=1 gi\|74003288, gi\|... - gi\|74003320\|ref\|XP_858515.1\| PREDICTED: similar to adaptor-related protein complex 2, mu 1 subunit i... AP2M1_MACFA - AP-2 complex subunit mu OS=Macaca fascicularis GN=AP2M1 PE=2 SV=1	4.0E-97	[1..540]	[1..429]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	9.0E-97	[1..540]	[1..429]
gi\|119598696, gi... - gi\|68799814\|ref\|NP_001020376.1\| adaptor-related protein complex 2, mu 1 subunit isoform b [Homo sapi... gi\|74003298, gi\|... - gi\|74003324\|ref\|XP_858593.1\| PREDICTED: similar to adaptor-related protein complex 2, mu 1 subunit i... gi\|114590723, gi... - gi\|114590723\|ref\|XP_001144254.1\| PREDICTED: adaptor-related protein complex 2, mu 1 subunit isoform ... tr\|M3W8D5\|M3W8D5... - Adaptor related protein complex 2 mu 1 subunit OS=Felis catus GN=AP2M1 PE=3 SV=1 IPI:IPI00777075.... - Ensembl_locations(Chr-bp):11-5344589, Tax_Id=10116 Gene_Symbol=Ap2m1 49 kDa protein, Uncharacterized... gi\|148665155, gi... - gi\|74197238\|dbj\|BAE35162.1\| unnamed protein product [Mus musculus], gi\|148665155\|gb\|EDK97571.1\| adap... gi\|109042898, gi... - gi\|109042898\|ref\|XP_001102510.1\| PREDICTED: similar to adaptor-related protein complex 2, mu 1 subun... gi\|149731156 - gi\|149731156\|ref\|XP_001497163.1\| PREDICTED: adaptor-related protein complex 2, mu 1 subunit isoform ... gi\|76607427\|ref\|... - PREDICTED: similar to adaptor-related protein complex 2, mu 1 subunit isoform b isoform 1 [Bos tauru...	2.0E-96	[1..540]	[1..427]
gi\|18542438 - gi\|18542438\|gb\|AAL75583.1\|AF467697_1 clathrin-adaptor protein [Dermacentor variabilis]	3.0E-96	[1..540]	[1..429]
gi\|7716656, gi\|7... - gi\|7716668\|gb\|AAF68484.1\|AF252650_1 clathrin adaptor protein AP-50 [Drosophila simulans], gi\|7716666...	1.0E-93	[4..536]	[1..424]
gi\|7716916 - gi\|7716916\|gb\|AAF68608.1\|AF255311_1 clathrin adaptor protein AP50 [Drosophila yakuba]	2.0E-93	[4..536]	[1..424]

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Predicted Domain #1

Region A:
Residues: [1-143]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSLFILDE NLEPLVSKNI RALPNLSSVL SSFKQCYHDG SPPILSQNDW FFIHLKRDFL  60
   61 HFVSVIHTTD KPNIDLMTIL AFLEQFYHLL QKYFEIEVLT KNVILDNILL VLELIDECID 120
  121 FGIVQVTDPS IIKDYIRVKV NVP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	341.0103
Match:	1gw5M_
Description:	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [144-544]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVTVDNEEWS PGEESSSSSG SDSDSEYSNT NKRKDKKKKR KKKKGTKGKS VGKSKLKSIM  60
   61 VNNKENRGIN VVETVKETLR NKNDTGKEAA NDELPNDGND LYINGDIAKT IIMPISWRTK 120
  121 GIHYAKNEFF LDVIERVQYL MDFEKGVIRK NLIHGEIVCR CYLSGMPKLK ISINKILNRD 180
  181 PQFMSNSSFH QCVSLDSINT IEKDEEKNSD DDAGLQAATD AREIEFIPPD GEFVLCQYEL 240
  241 KRHVKDAPMV RLKDFEIKPK LKKFKIQIVT KIQTNFKPTN STSKLNVRIP LTKVFQEYKI 300
  301 DLSKQIRFKA NIGKVVFNLS DDFLLWEIQT MKGHREHSTN KSSQYNSDED DPNTCASMVA 360
  361 EFPLFNQEEY DRLQEEMKTS MNPPPLRTGP RLEELYRQVH D

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	341.0103
Match:	1gw5M_
Description:	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [545-605]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQTSHVTPRD KLVNIDFEIP YCTCSGLKVE YLKVEEPQLQ YQSFPWVRYK TVSDEEYAYI  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.13
Match:	1gw5M
Description:	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits