YRC Public Data Repository - Protein Structure Prediction

Protein:	FENR2_LISMO
Organism:	Listeria monocytogenes EGD-e
Length:	331 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FENR2_LISMO.

Description	E-value	Query Range	Subject Range
FENR2_LISIN - Ferredoxin--NADP reductase 2 OS=Listeria innocua GN=lin2489 PE=3 SV=1 FENR2_LISIN - Ferredoxin--NADP reductase 2 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=lin2489 PE=3 SV=1	241.0	[0..1]	[331..1]
gi\|254992246 - gi\|254992246\|ref\|ZP_05274436.1\| thioredoxine reductase [Listeria monocytogenes FSL J2-064] gi\|47018629, gi\|... - gi\|47092975\|ref\|ZP_00230755.1\| pyridine nucleotide-disulfide oxidoreductase family protein [Listeria... gi\|217332774, gi... - gi\|217963504\|ref\|YP_002349182.1\| pyridine nucleotide-disulfide oxidoreductase family protein [Lister... gi\|254873687, gi... - gi\|254873687\|ref\|ZP_05246397.1\| thioredoxine reductase [Listeria monocytogenes FSL N1-017], gi\|15316... gi\|254826348 - gi\|254826348\|ref\|ZP_05231349.1\| thioredoxine reductase [Listeria monocytogenes FSL J1-194] gi\|225877405, gi... - gi\|226224943\|ref\|YP_002759050.1\| thioredoxine reductase [Listeria monocytogenes Clip81459], gi\|22587... gi\|254880405 - gi\|254880405\|ref\|ZP_05253115.1\| thioredoxine reductase [Listeria monocytogenes FSL J2-071] gi\|254933662, gi... - gi\|254933662\|ref\|ZP_05267021.1\| thioredoxine reductase [Listeria monocytogenes HPB2262], gi\|15320396... gi\|254854458 - gi\|254854458\|ref\|ZP_05243806.1\| thioredoxine reductase [Listeria monocytogenes FSL R2-503]	240.0	[0..1]	[331..1]
FENR2_LISMF - Ferredoxin--NADP reductase 2 OS=Listeria monocytogenes serotype 4b (strain F2365) GN=LMOf2365_2364 P...	239.0	[0..1]	[331..1]
FENR_BACHD - Ferredoxin--NADP reductase OS=Bacillus halodurans GN=BH3408 PE=3 SV=1 FENR_BACHD - Ferredoxin--NADP reductase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM...	234.0	[0..1]	[330..1]
FENR2_BACSK - Ferredoxin--NADP reductase 2 OS=Bacillus clausii (strain KSM-K16) GN=ABC2925 PE=3 SV=1	233.0	[0..1]	[330..1]
gi\|83633200, gi\|... - gi\|83645157\|ref\|YP_433592.1\| thioredoxin-disulfide reductase [Hahella chejuensis KCTC 2396], gi\|8363...	233.0	[0..1]	[316..1]
gi\|18893541, gi\|... - gi\|18977794\|ref\|NP_579151.1\| thioredoxin reductase [Pyrococcus furiosus DSM 3638], gi\|18893541\|gb\|AA...	231.0	[0..3]	[317..39]
gi\|15602438, gi\|... - gi\|15602438\|ref\|NP_245510.1\| hypothetical protein PM0573 [Pasteurella multocida subsp. multocida str...	230.0	[0..3]	[319..2]
gi\|52841994, gi\|... - gi\|52841994\|ref\|YP_095793.1\| thioredoxin reductase [Legionella pneumophila subsp. pneumophila str. P...	228.0	[0..5]	[316..37]

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Predicted Domain #1

Region A:
Residues: [1-331]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEKTKIYDI TIIGGGPVGL FAAFYAGMRN ASVKIIESLP QLGGQLSTLY PEKYIYDIPG  60
   61 YPSVRAQELV NNLIQQMKPF DPTVALEEAV QSVEKQVDGT FEIITKKDTH YSKAIIITAG 120
  121 NGAFEPRRLD LPEAEQYEGT NIHYFINDLS RFSGRRVAVC GGGDSAVDWA LMLEKVASSV 180
  181 AIVHRRNAFR AHEHSVNNLE KSSIAIKTPF IPTEVLGNGD KLTHITLQEV KGDTTETLEI 240
  241 DDFIINYGFV SSLGPIKNWG LELERNSIVV NSKMETSIPG IYCAGDICTY DGKVKLIATG 300
  301 FGEAPTAVNN AMNFIDPKTR VQPMHSTSLF E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.0
Match:	1tdeA
Description:	CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thioredoxin-disulfide reductase activity	3.42654162439464	bayes_pls_golite062009
antioxidant activity	3.37477730756688	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.17769237742078	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.45104542724719	bayes_pls_golite062009
binding	1.4227698123368	bayes_pls_golite062009
oxidoreductase activity	0.44090433301056	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.1498172520052	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.130601418359425	bayes_pls_golite062009
protein binding	0.116927178396589	bayes_pls_golite062009
disulfide oxidoreductase activity	0.0160065137614933	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: