YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRK_LISMO
Organism:	Listeria monocytogenes EGD-e
Length:	254 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRK_LISMO.

Description	E-value	Query Range	Subject Range
PYRK_LISIN - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Listeria innocua serovar 6a (s... PYRK_LISIN - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Listeria innocua GN=pyrK PE=3 ...	227.0	[0..1]	[254..1]
PYRK_LISMF - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Listeria monocytogenes serotyp...	225.0	[0..1]	[254..1]
gi\|47096555, gi\|... - gi\|47096555\|ref\|ZP_00234145.1\| dihydroorotate dehydrogenase, electron transfer subunit [Listeria mon... gi\|133732514, gi... - gi\|153179870\|ref\|ZP_01933043.1\| dihydroorotate dehydrogenase, electron transfer subunit [Listeria mo...	223.0	[0..6]	[254..1]
PYRK_BACCL - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Bacillus caldolyticus GN=pyrK ...	207.0	[0..5]	[254..6]
PYRK_GEOKA - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Geobacillus kaustophilus (stra... PYRK_GEOKA - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Geobacillus kaustophilus GN=py...	207.0	[0..5]	[254..6]
PYRK_BACSU - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Bacillus subtilis (strain 168)... gi\|221313752 - gi\|221313752\|ref\|ZP_03595557.1\| dihydroorotate dehydrogenase electron transfer subunit [Bacillus sub... gi\|221318676 - gi\|221318676\|ref\|ZP_03599970.1\| dihydroorotate dehydrogenase electron transfer subunit [Bacillus sub... gi\|221322948 - gi\|221322948\|ref\|ZP_03604242.1\| dihydroorotate dehydrogenase electron transfer subunit [Bacillus sub... PYRK_BACSU - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit OS=Bacillus subtilis GN=pyrK PE=1...	206.0	[0..1]	[254..1]
gi\|116515976, gi... - gi\|116515976\|ref\|YP_816333.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcus ... gi\|148998602, gi... - gi\|148998602\|ref\|ZP_01826042.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcu... gi\|168995877, gi... - gi\|169833375\|ref\|YP_001694408.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococc... gi\|25332350 - pir\|\|A97980 dihydroorotate oxidase (EC 1.3.3.1) pyrDII [imported] - Streptococcus pneumoniae (strain... gi\|220674186, gi... - gi\|221231726\|ref\|YP_002510878.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococc... gi\|168494392, gi... - gi\|183575672\|gb\|EDT96200.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcus pn... gi\|183578588, gi... - gi\|183578588\|gb\|EDT99116.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcus pn... gi\|15458469, gi\|... - gi\|15902909\|ref\|NP_358459.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcus p... gi\|242245242, gi... - gi\|242245242\|ref\|ZP_04799679.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcu... gi\|147764872, gi... - gi\|149010391\|ref\|ZP_01831762.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcu... gi\|225722126, gi... - gi\|225858756\|ref\|YP_002740266.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococc... gi\|149002513, gi... - gi\|149002513\|ref\|ZP_01827447.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcu... gi\|237821896 - gi\|237821896\|ref\|ZP_04597741.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococcu...	205.0	[0..5]	[254..16]
gi\|47018572, gi\|... - gi\|47093071\|ref\|ZP_00230849.1\| dihydroorotate dehydrogenase, electron transfer subunit [Listeria mon...	205.0	[0..31]	[254..1]
gi\|111658036 - gi\|111658036\|ref\|ZP_01408738.1\| hypothetical protein SpneT_02000769 [Streptococcus pneumoniae TIGR4] gi\|182629243, gi... - gi\|182683909\|ref\|YP_001835656.1\| dihydroorotate dehydrogenase electron transfer subunit [Streptococc...	205.0	[0..5]	[254..16]

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Predicted Domain #1

Region A:
Residues: [1-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQTEMKVIQ QTEIADKVYE LILTGECVAG MSPGQFLMLK PSRSDLLMRR PISICSYDKT  60
   61 AKTCILLYRV EGDGTRDFSK LSEGDTIDVL GPLGKGFDID TTPAPKTALL IGGGIGVPPM 120
  121 YQLGKELAEK GVQVMFVNGF QSAKDSFYAQ EMAEYGTVHI ATVDGSLGTQ GFVTDITKNF 180
  181 PEEPDVIYSC GPKAMLQAVK ASFPETKTYL SLEERMACGI GACYACVCPK ADDTNKQFKV 240
  241 CEDGPVFRAD EVKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.221849
Match:	1ep1B
Description:	Dihydroorotate dehydrogenase B, PyrK subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.82418089257266	bayes_pls_golite062009
oxidoreductase activity	1.06930052685144	bayes_pls_golite062009
dihydroorotate dehydrogenase activity	0.67910028759775	bayes_pls_golite062009
transferase activity	0.20565726169867	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: