YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|558099
Organism:	Homo sapiens
Length:	706 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|558099.

Description	E-value	Query Range	Subject Range
gi\|76678711 - gi\|76678711\|ref\|XP_877752.1\| PREDICTED: similar to protein kinase C, delta isoform 6 [Bos taurus]	670.0	[0..1]	[705..1]
PRKCQ - protein kinase C, theta	668.0	[0..1]	[706..1]
gi\|114629235, gi... - gi\|114629237\|ref\|XP_001148074.1\| PREDICTED: protein kinase C, theta isoform 2 [Pan troglodytes], gi\|...	667.0	[0..1]	[706..1]
gi\|73949094 - gi\|73949094\|ref\|XP_849292.1\| PREDICTED: similar to Protein kinase C, theta type (nPKC-theta) isoform...	667.0	[0..1]	[706..1]
gi\|62663808, gi\|... - gi\|62663808\|ref\|XP_341554.2\| PREDICTED: similar to Protein kinase C theta type (nPKC-theta) isoform ...	662.0	[0..1]	[705..1]
KPCT_MOUSE - Protein kinase C theta type OS=Mus musculus GN=Prkcq PE=1 SV=1	661.0	[0..1]	[705..1]

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Predicted Domain #1

Region A:
Residues: [1-49]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.39794
Match:	1yrkA
Description:	The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [50-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTMYPPWDST FDAHINKGRV MQIIVKGKNV DLISETTVEL YSLAERCRKN NGKTEIWLEL  60
   61 KPQGRMLMNA RYFLEMSDTK DMNEFETEGF FALHQRRGAI KQAKVHHVKC HEFTATFFPQ 120
  121 PTFCSVCHEF VWGLNKQGYQ CRQCNAAIHK KCIDKVIAKC TGSAINSRET MFHKERFKID 180
  181 MPHRFKVYNY KSPTFCEHCG TLLWGLARQG LKC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.522879
Match:	1xa6A
Description:	Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [263-648]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DACGMNVHHR CQTKVANLCG INQKLMAEAL AMIESTQQAR CLRDTEQIFR EGPVEIGLPC  60
   61 SIKNEARLPC LPTPGKREPQ GISWESPLDE VDKMCHLPEP ELNKERPSLQ IKLKIEDFIL 120
  121 HKMLGKGSFG KVFLAEFKKT NQFFAIKALK KDVVLMDDDV ECTMVEKRVL SLAWEHPFLT 180
  181 HMFCTFQTKE NLFFVMEYLN GGDLMYHIQS CHKFDLSRAT FYAAEIILGL QFLHSKGIVY 240
  241 RDLKLDNILL DKDGHIKIAD FGMCKENMLG DAKTNTFCGT PDYIAPEILL GQKYNHSVDW 300
  301 WSFGVLLYEM LIGQSPFHGQ DEEELFHSIR MDNPFYPRWL EKEAKDLLVK LFVREPEKRL 360
  361 GVRGDIRQHP LFREINWEEL ERKEID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.69897
Match:	1opkA
Description:	Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [649-706]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPFRPKVKSP FDCSNFDKEF LNEKPRLSFA DRALINSMDQ NMFRNFSFMN PRMERLIS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	95.30103
Match:	1xjdA
Description:	Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits