YRC Public Data Repository - Protein Structure Prediction

Protein:	EG10427
Organism:	Escherichia coli str. K-12 substr. MG1655
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG10427.

Description	E-value	Query Range	Subject Range
gi\|237705171, gi... - gi\|237705171\|ref\|ZP_04535652.1\| glutamyl-tRNA reductase [Escherichia sp. 3_2_53FAA], gi\|226899928\|gb... gi\|26107934, gi\|... - gi\|26247533\|ref\|NP_753573.1\| glutamyl-tRNA reductase [Escherichia coli CFT073], gi\|26107934\|gb\|AAN80... gi\|91072005, gi\|... - gi\|91210431\|ref\|YP_540417.1\| glutamyl-tRNA reductase [Escherichia coli UTI89], gi\|91072005\|gb\|ABE068...	384.0	[0..1]	[418..67]
gi\|110614763, gi... - gi\|110805215\|ref\|YP_688735.1\| glutamyl-tRNA reductase [Shigella flexneri 5 str. 8401], gi\|110614763\|... gi\|24112609, gi\|... - ref\|NP_707119.1\| glutamyl-tRNA reductase [Shigella flexneri 2a str. 301], gb\|AAN42826.1\| glutamyl-t...	384.0	[0..1]	[418..67]
HEM1_ESCF3 - Glutamyl-tRNA reductase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) GN=h... gi\|83569314 - gi\|83569314\|ref\|ZP_00920770.1\| COG0373: Glutamyl-tRNA reductase [Shigella dysenteriae 1012]	381.0	[0..1]	[418..1]
gi\|15801439, gi\|... - gi\|15801439\|ref\|NP_287456.1\| glutamyl-tRNA reductase [Escherichia coli O157:H7 EDL933], gi\|12514923\|... gi\|25286556 - gi\|25286556\|pir\|\|H85700 hypothetical protein hemA [imported] - Escherichia coli (strain O157:H7, su...	380.0	[0..1]	[418..1]
gi\|194437120, gi... - gi\|83587354\|ref\|ZP_00925982.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli 101-1], gi\|1944371... HEM1_ECOLC - Glutamyl-tRNA reductase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=hemA PE=3 SV=1 gi\|253977407, gi... - gi\|254288100\|ref\|YP_003053848.1\| glutamyl-tRNA reductase [Escherichia coli BL21(DE3)], gi\|253977407\|... gi\|124528407, gi... - gi\|124528407\|ref\|ZP_01699717.1\| Shikimate/quinate 5-dehydrogenase [Escherichia coli B], gi\|124500639... gi\|251784716, gi... - gi\|251784716\|ref\|YP_002999020.1\| hypothetical protein B21_01195 [Escherichia coli BL21], gi\|24237698... gi\|254161292, gi... - gi\|254161292\|ref\|YP_003044400.1\| glutamyl-tRNA reductase [Escherichia coli B str. REL606], gi\|253973... gi\|188494819, gi... - gi\|75511754\|ref\|ZP_00734383.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli 53638], gi\|1884948... HEM1_ECOHS - Glutamyl-tRNA reductase OS=Escherichia coli O9:H4 (strain HS) GN=hemA PE=3 SV=1	380.0	[0..1]	[418..1]
HEM1_ECO45 - Glutamyl-tRNA reductase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=hemA PE=3 SV=1 HEM1_ECO81 - Glutamyl-tRNA reductase OS=Escherichia coli O81 (strain ED1a) GN=hemA PE=3 SV=1 HEM1_ECOL6 - Glutamyl-tRNA reductase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=hemA PE=3 ... gi\|227836572, gi... - gi\|227886368\|ref\|ZP_04004173.1\| glutamyl-tRNA reductase [Escherichia coli 83972], gi\|227836572\|gb\|EE... gi\|75242014, gi\|... - gi\|75242014\|ref\|ZP_00725808.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli F11], gi\|191171014... HEM1_ECOL6 - Glutamyl-tRNA reductase OS=Escherichia coli O6 GN=hemA PE=3 SV=2 HEM1_ECOUT - Glutamyl-tRNA reductase OS=Escherichia coli (strain UTI89 / UPEC) GN=hemA PE=3 SV=2	379.0	[0..1]	[418..1]
gi\|194426136, gi... - gi\|75212648\|ref\|ZP_00712646.1\| COG0373: Glutamyl-tRNA reductase [Escherichia coli B171], gi\|19442613... HEM1_SHISS - Glutamyl-tRNA reductase OS=Shigella sonnei (strain Ss046) GN=hemA PE=3 SV=1 HEM1_SHIB3 - Glutamyl-tRNA reductase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=hemA PE=3 SV=... HEM1_ECO24 - Glutamyl-tRNA reductase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=hemA PE=3 SV=1 HEM1_SHIBS - Glutamyl-tRNA reductase OS=Shigella boydii serotype 4 (strain Sb227) GN=hemA PE=3 SV=1 HEM1_ECO8A - Glutamyl-tRNA reductase OS=Escherichia coli O8 (strain IAI1) GN=hemA PE=3 SV=1 HEM1_ECO55 - Glutamyl-tRNA reductase OS=Escherichia coli (strain 55989 / EAEC) GN=hemA PE=3 SV=1 HEM1_ECOSE - Glutamyl-tRNA reductase OS=Escherichia coli (strain SE11) GN=hemA PE=3 SV=1	379.0	[0..1]	[418..1]
gi\|205339555, gi... - gi\|205339555\|gb\|EDZ26319.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Hei... gi\|205350779, gi... - gi\|205350779\|gb\|EDZ37410.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Had... gi\|195634371, gi... - gi\|195634371\|gb\|EDX52723.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar New... gi\|205342650, gi... - gi\|205342650\|gb\|EDZ29414.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Wel... lcl\|NC_016856.1_... - [gene=hemA] [protein=glutamyl-tRNA reductase] [protein_id=YP_005237706.1] [location=complement(18851... gi\|205321990, gi... - gi\|205321990\|gb\|EDZ09829.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Sai... gi\|205328701, gi... - gi\|205328701\|gb\|EDZ15465.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar 4,[... gi\|205332114, gi... - gi\|205332114\|gb\|EDZ18878.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Ken... gi\|197289194, gi... - gi\|197289194\|gb\|EDY28561.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Sch... HEM1_SALTY - Glutamyl-tRNA reductase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=hemA PE=3... gi\|213426494 - gi\|213426494\|ref\|ZP_03359244.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... gi\|29137198, gi\|... - gi\|29141571\|ref\|NP_804913.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Ty... gi\|213583754 - gi\|213583754\|ref\|ZP_03365580.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... gi\|16760670 - gi\|16760670\|ref\|NP_456287.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar Ty... gi\|204322934, gi... - gi\|204927592\|ref\|ZP_03218793.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... HEM1_SALG2 - Glutamyl-tRNA reductase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=hemA PE=3 SV=1 HEM1_SALEP - Glutamyl-tRNA reductase OS=Salmonella enteritidis PT4 (strain P125109) GN=hemA PE=3 SV=1 gi\|213051787 - gi\|213051787\|ref\|ZP_03344665.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... HEM1_SALTY - Glutamyl-tRNA reductase OS=Salmonella typhimurium GN=hemA PE=3 SV=1 HEM1_SALA4 - Glutamyl-tRNA reductase OS=Salmonella agona (strain SL483) GN=hemA PE=3 SV=1 gi\|197241202, gi... - gi\|197262947\|ref\|ZP_03163021.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... HEM1_SALPK - Glutamyl-tRNA reductase OS=Salmonella paratyphi A (strain AKU_12601) GN=hemA PE=3 SV=1 gi\|199602893, gi... - gi\|200390448\|ref\|ZP_03217059.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... HEM1_SALNS - Glutamyl-tRNA reductase OS=Salmonella newport (strain SL254) GN=hemA PE=3 SV=1 gi\|238913677 - gi\|238913677\|ref\|ZP_04657514.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... HEM1_SALHS - Glutamyl-tRNA reductase OS=Salmonella heidelberg (strain SL476) GN=hemA PE=3 SV=1 gi\|194471470, gi... - gi\|194471470\|ref\|ZP_03077454.1\| glutamyl-tRNA reductase [Salmonella enterica subsp. enterica serovar... HEM1_SALSV - Glutamyl-tRNA reductase OS=Salmonella schwarzengrund (strain CVM19633) GN=hemA PE=3 SV=1 HEM1_SALPB - Glutamyl-tRNA reductase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=hemA PE=3 SV=1 HEM1_SALTY - Glutamyl-tRNA reductase OS=Salmonella typhimurium GN=hemA PE=3 SV=1 HEM1_SALTI - Glutamyl-tRNA reductase OS=Salmonella typhi GN=hemA PE=3 SV=1 HEM1_SALTI - Glutamyl-tRNA reductase OS=Salmonella typhi GN=hemA PE=3 SV=1 HEM1_SALPA - Glutamyl-tRNA reductase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=hemA PE=3 SV=1 HEM1_SALPB - Glutamyl-tRNA reductase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=hemA PE=3 SV=1 HEM1_SALPA - Glutamyl-tRNA reductase OS=Salmonella paratyphi A GN=hemA PE=3 SV=1 HEM1_SALAR - Glutamyl-tRNA reductase OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) GN=hemA P...	379.0	[0..1]	[418..1]
HEM1_SALCH - Glutamyl-tRNA reductase OS=Salmonella choleraesuis GN=hemA PE=3 SV=1 HEM1_SALCH - Glutamyl-tRNA reductase OS=Salmonella choleraesuis (strain SC-B67) GN=hemA PE=3 SV=1 HEM1_SALCH - Glutamyl-tRNA reductase OS=Salmonella choleraesuis GN=hemA PE=3 SV=1	378.0	[0..1]	[418..1]
HEM1_SHIFL - Glutamyl-tRNA reductase OS=Shigella flexneri GN=hemA PE=3 SV=2 gi\|56479855, gi\|... - gi\|56479855\|ref\|NP_707119.2\| glutamyl-tRNA reductase [Shigella flexneri 2a str. 301], gi\|56383406\|gb... gi\|30040982, gi\|... - gi\|30062734\|ref\|NP_836905.1\| glutamyl-tRNA reductase [Shigella flexneri 2a str. 2457T], gi\|30040982\|... HEM1_SHIF8 - Glutamyl-tRNA reductase OS=Shigella flexneri serotype 5b (strain 8401) GN=hemA PE=3 SV=2	378.0	[0..1]	[418..1]

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Predicted Domain #1

Region A:
Residues: [1-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLALGINH KTAPVSLRER VSFSPDKLDQ ALDSLLAQPM VQGGVVLSTC NRTELYLSVE  60
   61 EQDNLQEALI RWLCDYHNLN EEDLRKSLYW HQDNDAVSHL MRVASGLDSL VLGEPQILGQ 120
  121 VKKAFADSQK GHMKASELER MFQKSFSVAK RVRTETDIGA SAVSVAFAAC TLARQIFESL 180
  181 STVTVLLVGA GETIELVARH LREHKVQKMI IANRTRERAQ ILADEVGAEV IALSDIDERL 240
  241 READIIISST ASPLPIIGKG MVERALKSRR NQPMLLVDIA VPRDVEPEVG KLANAYLYSV 300
  301 DDLQSIISHN LAQRKAAAVE AETIVAQETS EFMAWLRAQS ASETIREYRS QAEQVRDELT 360
  361 AKALAALEQG GDAQAIMQDL AWKLTNRLIH APTKSLQQAA RDGDNERLNI LRDSLGLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.09691
Match:	1gpjA
Description:	Glutamyl tRNA-reductase dimerization domain; Glutamyl tRNA-reductase middle domain; Glutamyl tRNA-reductase catalytic, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.16785883389468	bayes_pls_golite062009
oxidoreductase activity	1.13814306448308	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: