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View Structure Prediction Details

Protein: ENSPTRT00000012343
Organism: Pan troglodytes
Length: 745 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENSPTRT00000012343.

Description E-value Query
Range
Subject
Range
gi|73964450 - gi|73964450|ref|XP_537551.2| PREDICTED: similar to poly(A) polymerase alpha [Canis familiaris]
0.0 [4..745] [77..812]
gi|149044213, gi... - gi|62651213|ref|XP_234508.3| PREDICTED: similar to poly (A) polymerase alpha [Rattus norvegicus], gi...
0.0 [1..745] [1..739]
gi|162318632 - gi|162318632|gb|AAI56655.1| Poly (A) polymerase alpha [synthetic construct]
PAPOA_MOUSE - Poly(A) polymerase alpha OS=Mus musculus GN=Papola PE=1 SV=4
0.0 [1..745] [1..739]
PAPOA_BOVIN - Poly(A) polymerase alpha OS=Bos taurus GN=PAPOLA PE=1 SV=3
0.0 [1..745] [1..739]
gi|50748668 - gi|50748668|ref|XP_421352.1| PREDICTED: similar to poly(A) polymerase alpha [Gallus gallus]
0.0 [2..745] [79..815]

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Predicted Domain #1
Region A:
Residues: [1-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG VFEEEEELQR  60
   61 RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF GSYRLGVHTK GADIDALCVA 120
  121 PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE EAFVPVIKLC FDGIEIDILF ARLALQTIPE 180
  181 DLDLRDDSLL KNLDIRCIRS LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI 240
  241 LGFLGGVSWA MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW 300
  301 DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE ILLSKAEWSK 360
  361 LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS 420
  421 FPAPKENPDK EEFRTMWVIG LVFKKTENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFEVD 480
  481 MKIAAMHVKR KQLHQLLPNH 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 151.0
Match: 1f5aA
Description: Poly(A) polymerase, middle domain; Poly(A) polymerase N-terminal, catalytic domain; Poly(A) polymerase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 2.46555984694381 bayes_pls_golite062009
nucleotidyltransferase activity 1.61922062344227 bayes_pls_golite062009
nucleic acid binding 1.43322212500405 bayes_pls_golite062009
polynucleotide adenylyltransferase activity 1.24026612395993 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.08480919674453 bayes_pls_golite062009
DNA binding 0.920001549206154 bayes_pls_golite062009
binding 0.888087430062829 bayes_pls_golite062009
catalytic activity 0.75232920999699 bayes_pls_golite062009
transferase activity 0.432029324907561 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [501-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLQKKKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS ATKTSPLNSS GSSQGRNSPA  60
   61 PAVTAASVTN IQATEVSVPQ VNSSESSGGT SSESIPQTAT QPAISPPPKP TVSRVVSSTR 120
  121 LVNPPPRSSG NAATSGNAAT KIPTP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.54
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #3
Region A:
Residues: [646-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVGVKRTSSP HKEESPKKTK TEEDETSEDA NCLALSGHDK TEAKEQLDTE TSTTQSETIQ  60
   61 TAASLLASQK TSSTDLSDIP ALPANPIPVI KNSIKLRLNR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle