YRC Public Data Repository - Protein Structure Prediction

Protein:	PGRC2_MOUSE
Organism:	Mus musculus
Length:	217 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGRC2_MOUSE.

Description	E-value	Query Range	Subject Range
PGRC2_RAT - Membrane-associated progesterone receptor component 2 OS=Rattus norvegicus GN=Pgrmc2 PE=1 SV=1	252.0	[0..1]	[217..1]
PGRC2_MOUSE - (Q80UU9) Membrane-associated progesterone receptor component 2 (Fragment)	246.0	[0..4]	[217..1]
gi\|123994037, gi... - gi\|124000713\|gb\|ABM87865.1\| progesterone receptor membrane component 2 [synthetic construct], gi\|124... PGRMC2 - progesterone receptor membrane component 2	235.0	[0..1]	[217..1]
gi\|114595991 - gi\|114595991\|ref\|XP_517434.2\| PREDICTED: similar to progresterone binding protein [Pan troglodytes]	233.0	[0..1]	[217..25]
gi\|61859954 - gi\|61859954\|ref\|XP_613630.1\| PREDICTED: similar to progesterone membrane binding protein [Bos taurus...	230.0	[0..1]	[217..25]
gi\|109075624 - gi\|109075624\|ref\|XP_001082791.1\| PREDICTED: similar to progesterone membrane binding protein [Macaca...	226.0	[0..1]	[217..25]
gi\|57100531 - gi\|57100531\|ref\|XP_533292.1\| PREDICTED: similar to progesterone membrane binding protein [Canis fami...	224.0	[0..1]	[217..1]
gi\|185134138, gi... - gi\|25046107\|gb\|AAL49963.1\| progestin membrane receptor component 1 [Oncorhynchus mykiss], gi\|1851341...	202.0	[0..29]	[216..2]
gi\|57530130, gi\|... - gi\|57530130\|ref\|NP_001006441.1\| progesterone receptor membrane component 2 [Gallus gallus], gi\|53128...	189.0	[0..63]	[217..43]
gi\|47085845, gi\|... - gi\|47085845\|ref\|NP_998269.1\| progesterone receptor membrane component 2 [Danio rerio], gi\|31418224\|g...	188.0	[0..3]	[217..2]

Back

Predicted Domain #1

Region A:
Residues: [1-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGDGDVKL STLGSGGESG GDGSPGGAGA TAARSSWVAA LLATGGEMLL NVALVALVLL  60
   61 GAYRLWVRWG RRGL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [75-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSGPGAGEES PAATLPRMKK RDFSLEQLRQ YDGARTPRIL LAVNGKVFDV TKGSKFYGPA  60
   61 GPYGIFAGRD ASRGLATFCL DKDALRDEYD DLSDLNAVQM ESVREWEMQF KEKYDYVGRL 120
  121 LKPGEEPSEY TDEEDTKDHS KQD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.221849
Match:	1j03A
Description:	Solution structure of a putative steroid-binding protein from Arabidopsis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.05227276400356	bayes_pls_golite062009
binding	0.187915229185258	bayes_pls_golite062009
steroid binding	0.177535173083536	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: