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View Structure Prediction Details

Protein: gi|124505617, gi...
Organism: Plasmodium falciparum 3D7
Length: 1222 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|124505617, gi....

Description E-value Query
Range
Subject
Range
gi|117499872 - gi|117499872|gb|ABK34941.1| cyclin-dependent kinase 2 [Capra hircus]
gi|215983068, gi... - gi|215983068|ref|NP_001135981.1| cyclin-dependent kinase 2 [Ovis aries], gi|213688920|gb|ACJ53943.1|...
CDK2_BOVIN - Cyclin-dependent kinase 2 OS=Bos taurus GN=CDK2 PE=2 SV=1
273.0 [0..914] [1221..1]
CDK2_RAT - Cyclin-dependent kinase 2 OS=Rattus norvegicus GN=Cdk2 PE=1 SV=1
gi|710025 - gi|710025|dbj|BAA05947.1| cyclin dependent kinase 2-alpha [Rattus rattus]
273.0 [0..914] [1221..1]
gi|29849 - gi|29849|emb|CAA43807.1| CDK2 [Homo sapiens]
273.0 [0..914] [1221..1]
tr|M3WJU6|M3WJU6... - Cyclin dependent kinase 2 OS=Felis catus GN=CDK2 PE=3 SV=1
gi|73968309 - gi|73968309|ref|XP_856049.1| PREDICTED: similar to cyclin-dependent kinase 2 isoform 6 [Canis famili...
272.0 [0..914] [1221..1]
gi|109097199 - gi|109097199|ref|XP_001113345.1| PREDICTED: cyclin-dependent kinase 2 isoform 6 [Macaca mulatta]
272.0 [0..914] [1221..1]
gi|30583821, gi|... - gi|61372546|gb|AAX43864.1| cyclin-dependent kinase 2 [synthetic construct], gi|60830574|gb|AAX36935....
272.0 [0..914] [1221..1]

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Predicted Domain #1
Region A:
Residues: [1-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYFSKYKVI ESNRLLYTSN VKYDNYFINI NKKNQVKNKN ESYSFIKLLF RKCIIFFIIY  60
   61 FLFIIPLNEV IYNKYDYSSK SIQHYCIRNL SECFRGKSAL NDDSESCRCS NLLKEKKKTE 120
  121 ENSEEIRKYL SDKTKKRNSL YKYKLKGSKG KSVKNIVGNK EGSIHENTDL YSDSDVEYDY 180
  181 GNLFYDCYYT EGLIDQGEEN EEEKFYEARE DFEGEEKNKC KIKESEKSFK KENDCKVENV 240
  241 ENINYERVYS WELGKEALTK LLGCSNKLSV NNVKYSDWKF KSIPTVGFSK DGDRLQEMYK 300
  301 ASVCSYTEEC QGEVYLFVKK IPIEVWIRQY NLMNDNDGEY LLDGENFI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 2nyyA
Description: No description for 2nyyA was found.

Predicted Domain #2
Region A:
Residues: [349-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAVACAYLS EHYPGLTPKL YKVLYEPECA NCNEEDKNMS ENNHKKDSKH KGDSNHKSDS  60
   61 NHKSDSNHKS DSNHKSGSNH KSDCNHKSGS NHKSDSNHQS DCNHMSDHNH KSDNNHKSDS 120
  121 SHKSDSSHKS DSSHKSGSNH KSDNNHKSDS SHKSGSNHKS DHNHKSDSNH KSDSNHKNES 180
  181 NHKNESNHKN ESNHKNESNH KNESNHKNDS 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.11
Match: 1wckA
Description: Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [559-799]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHKSDSNHMS DHNHKSDNNH KSDHNHMSDH NHKSDNNHKS DNNHMSDHNH KSDNNHKSDN  60
   61 NHKSDNNHKS DHNHMSDHNH KSDNNHKSDH NHKSDSNHMS DHNHMSDHNH KSDHNHKSDH 120
  121 NHKSDNNHKS DSNHKSDSNH KSDHNHKSDS NHMSDHNHMS DHNHKSDHNH KSDNNHKSDS 180
  181 NHKSDSNHKS DHNHKSDSNH MSDHNHMSDH NHMSDHNHKS DHNHKSDNNH KSDSNHKSDS 240
  241 N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [800-913]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKSDSNHKSD HNHKSDHKHM SDNNHKSDNN HKSDHNHKSD NNHKSDHNHK SDSNHKSDSN  60
   61 HKSDSNHKSD SNHKSDNNHK SDHNHNSDSN HMSDHNHKSD HNHKSDHNHK SDNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 2pziA
Description: No description for 2pziA was found.

Predicted Domain #5
Region A:
Residues: [914-1222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKSDNNHKSD HNHKSDHKKN NNNNKDNKND DNDDSDASDA VHEDIELLES YSDLNKFNEM  60
   61 LTEQLNKNKD GYVVLVTELF GEDLFQYINK RNENEDTRVR DEDKKIIMFE FLKLLIKLHN 120
  121 AGLVHLDISP ENILIENNGE LRLCDLAKCA PMYTHNLRHI KGNGNDLYSF QSCQPCVGKI 180
  181 PCIPKECWDI IREHIKLKID NPFEHLSTIT DQEERKKYYF DVHCVDKYML GIFYIWIWNL 240
  241 NYIWKRADPP NDRTFNNFLK YNLNINVFQL AKQWPKGLKD IINKLLSLES RMKTDLNELT 300
  301 EHPWWINED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.39794
Match: 1e9hA
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.686492203566958 bayes_pls_golite062009
transferase activity 0.66841261245817 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.66326000691279 bayes_pls_golite062009
kinase activity 0.65753777854807 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.64444215862273 bayes_pls_golite062009
protein kinase activity 0.56587465829201 bayes_pls_golite062009
binding 0.0554152720226 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle